DLG4 / PSD95 antibody

Principal name

DLG4 / PSD95 antibody

Alternative names for DLG4 / PSD95 antibody

DLGH4, PSD-95, Disks large homolog 4, SAP90, SAP-90, Postsynaptic density protein 95, Synapse-associated protein 90

SwissProt ID

P31016 (Rat), P78352 (Human), Q62108 (Mouse)

Gene ID

1742 (DLG4), 13385 (Dlg4), 29495

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Can (Canine), Ze (Zebrafish), Xen (Xenopus)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Immunoelectron Microscopy (EM), Paraffin Sections (P), Flow Cytometry (F)

Background of DLG4 / PSD95 antibody

Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex (1). These family members consist of an Nterminal variable segment followed by three aminoterminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain.
The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins (2). Thus different PDZ domains of PSD-95 might be specialized for distinct functions (3, 4).
PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) (5). The protein is implicated in experience dependent plasticity and plays an indispensable role in learning (6). Mutations in PSD95 are associated with autism (7).

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Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

DLG4 / PSD95 (transcript variant 1)

  Recombinant protein of human discs, large homolog 4 (Drosophila) (DLG4), transcript variant 1  
DLG4 / PSD95 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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