DLL3 antibody

Principal name

DLL3 antibody

Alternative names for DLL3 antibody

Delta-like protein 3, Delta-3

SwissProt ID

O88516 (Mouse), O88671 (Rat), P54655 (Xenla), Q9NYJ7 (Human)

Gene ID

10683 (DLL3)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Prim (Primate), Por (Porcine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of DLL3 antibody

DLL3(DELTA-LIKE 3) also known as DELTA, DROSOPHILA, HOMOLOG OF, is a protein which in humans is encoded by the DLL3 gene. This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutation in the mouse delta-like 3 gene (Dll3), which is homologous to the Notch-ligand delta in Drosophila, results in the mouse 'pudgy' phenotype. The human DLL3 gene was identified within a critical interval, mapped in 2 consanguineous Arab-Israeli and Pakistani SCDO1 pedigrees, of 7.8 cM at 19q13.1-q13.3 between D19S570 and D19S908 (Bulman et al., 2000). Dunwoodie et al. (1997) presented results suggesting that mouse Dll3 may complement the function of other delta homologs during early pattern formation in the mouse embryo. In humans, the fact that mutations in genes required for oscillation, such as DLL3, result in abnormal segmentation of the vertebral column suggests that the segmentation clock also acts during human embryonic development. This residue is highly conserved in Delta proteins from Drosophila to humans, and the substitution of a charged polar for a nonpolar residue may disrupt the conformation of the DLL3 protein.

General readings

Yerges, L.M. et al., J. Bone Miner. Res. 24(12): 2039-2049 (2009)
Heuss, S.F. et al., Proc. Natl. Acad. Sci. U.S.A. 105(32): 11212-11217 (2008)
Maisenbacher, M.K., et al. Hum. Genet. 116(5): 416-419 (2005)
Whittock, N.V. et al., Clin. Genet. 66(1): 67-72 (2004)
Bonafe, L. et al., Clin. Genet. 64(1): 28-35 (2003)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DLL3 antibody

Western Blot: DLL3 Antibody [TA337030] - Analysis of DLL3 in mouse embryo brain lysate in the 1) absence and 2) presence of immunizing peptide and 3) T98G cell lysate using DLL3 antibody at 3 and 5 ug/ml respectively. Goat anti-rabbit Ig HRP secondary ant Rabbit Purified Hu, Ms, Prim P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

DLL3 antibody

Host: Rabbit; Target Name: DLL3; Sample Tissue: Hela Whole cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Hu, Ms, Por WB
50 µg / €325.00
  OriGene Technologies, Inc.

DLL3 antibody

WB Suggested Anti-DLL3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

DLL3 (C-term) antibody

Immunohistochemistry analysis in human brain tissue (Formalin-fixed, Paraffin-embedded) using DLL3 antibody Cat.-No. AP51273PU-N (C-term), followed by peroxidase conjugated secondary antibody and DAB staining. This data demonstrates the use of DLL3 antibody for IHC. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

DLL3 (C-term) antibody

Immunohistochemistry anaysis of human brain tissue (Formalin-fixed, Paraffin-embedded) using DLL3 antibody Cat.-No. AP51274PU-N (C-term), follwed by peroxidase-conjugated secondary antibody and DAB staining. This data demonstrates the use of this antibody for IHC. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

DLL3 antibody

Human HepG2; WB Suggested Anti-DLL3 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: HepG2 cell lysate; DLL3 antibody - N-terminal region (ARP47292_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

DLL3 antibody

DLL3 Rabbit IgG Aff - Purified Hu WB
0.1 mg / €290.00
  Boster Immunoleader

DLL3 antibody

Western Blot: DLL3 Antibody [NBP1-69268] - This Anti-DLL3 antibody was used in Western Blot of HepG2 tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

Lysates (Overexpressed)

Catalog No.    

DLL3 overexpression lysate

DLL3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

9 Item(s)

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