DLL3 antibody

Principal name

DLL3 antibody

Alternative names for DLL3 antibody

Delta-like protein 3, Delta-3

SwissProt ID

O88516 (Mouse), O88671 (Rat), P54655 (Xenla), Q9NYJ7 (Human)

Gene ID

10683 (DLL3), 13389 (Dll3), 114125

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Prim (Primate), Por (Porcine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of DLL3 antibody

DLL3(DELTA-LIKE 3) also known as DELTA, DROSOPHILA, HOMOLOG OF, is a protein which in humans is encoded by the DLL3 gene. This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutation in the mouse delta-like 3 gene (Dll3), which is homologous to the Notch-ligand delta in Drosophila, results in the mouse 'pudgy' phenotype. The human DLL3 gene was identified within a critical interval, mapped in 2 consanguineous Arab-Israeli and Pakistani SCDO1 pedigrees, of 7.8 cM at 19q13.1-q13.3 between D19S570 and D19S908 (Bulman et al., 2000). Dunwoodie et al. (1997) presented results suggesting that mouse Dll3 may complement the function of other delta homologs during early pattern formation in the mouse embryo. In humans, the fact that mutations in genes required for oscillation, such as DLL3, result in abnormal segmentation of the vertebral column suggests that the segmentation clock also acts during human embryonic development. This residue is highly conserved in Delta proteins from Drosophila to humans, and the substitution of a charged polar for a nonpolar residue may disrupt the conformation of the DLL3 protein.

General readings

Yerges, L.M. et al., J. Bone Miner. Res. 24(12): 2039-2049 (2009)
Heuss, S.F. et al., Proc. Natl. Acad. Sci. U.S.A. 105(32): 11212-11217 (2008)
Maisenbacher, M.K., et al. Hum. Genet. 116(5): 416-419 (2005)
Whittock, N.V. et al., Clin. Genet. 66(1): 67-72 (2004)
Bonafe, L. et al., Clin. Genet. 64(1): 28-35 (2003)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DLL3 (C-term) antibody

Immunohistochemistry anaysis of human brain tissue (Formalin-fixed, Paraffin-embedded) using DLL3 antibody Cat.-No. AP51274PU-N (C-term), follwed by peroxidase-conjugated secondary antibody and DAB staining. This data demonstrates the use of this antibody for IHC. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

DLL3 antibody

  Rabbit Polyclonal DLL3 Antibody  
Western Blot: DLL3 Antibody [TA337030] - Analysis of DLL3 in mouse embryo brain lysate in the 1) absence and 2) presence of immunizing peptide and 3) T98G cell lysate using DLL3 antibody at 3 and 5 ug/ml respectively. Goat anti-rabbit Ig HRP secondary ant Rabbit Purified Hu, Ms, Prim P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

DLL3 antibody

  Rabbit Polyclonal Anti-DLL3 Antibody  
Host: Rabbit; Target Name: DLL3; Sample Tissue: Hela Whole cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Hu, Ms, Por WB
50 µg / €325.00
  OriGene Technologies, Inc.

DLL3 antibody

  Rabbit Polyclonal Anti-DLL3 Antibody  
WB Suggested Anti-DLL3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

DLL3 - human gene knockout kit via CRISPR

DLL3 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

DLL3 - human gene knockout kit via CRISPR

DLL3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

DLL3 - human gene knockout kit via CRISPR

DLL3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

DLL3 - human gene knockout kit via CRISPR

DLL3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dll3 - mouse gene knockout kit via CRISPR

Dll3 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Dll3 - mouse gene knockout kit via CRISPR

Dll3 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dll3 - mouse gene knockout kit via CRISPR

Dll3 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dll3 - mouse gene knockout kit via CRISPR

Dll3 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

DLL3 overexpression lysate

DLL3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, DLL3 (mGFP-tagged)-Human delta-like 3 (Drosophila) (DLL3), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, DLL3 (mGFP-tagged)-Human delta-like 3 (Drosophila) (DLL3), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,270.00
  OriGene Technologies, Inc.

Lenti ORF particles, DLL3 (Myc-DDK-tagged)-Human delta-like 3 (Drosophila) (DLL3), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, DLL3 (Myc-DDK-tagged)-Human delta-like 3 (Drosophila) (DLL3), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,140.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Dll3 (GFP-tagged) - Mouse delta-like 3 (Drosophila) (Dll3), 200 uL, >10^7 TU/mL

Lenti ORF particles, Dll3 (GFP-tagged) - Mouse delta-like 3 (Drosophila) (Dll3), 200 uL, >10^7 TU/mL  
200 µl / €1,230.00
  OriGene Technologies, Inc.

Lenti ORF particles, Dll3 (Myc-DDK-tagged) - Mouse delta-like 3 (Drosophila) (Dll3), 200 uL, >10^7 TU/mL

Lenti ORF particles, Dll3 (Myc-DDK-tagged) - Mouse delta-like 3 (Drosophila) (Dll3), 200 uL, >10^7 TU/mL  
200 µl / €1,100.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Dll3 (GFP-tagged ORF) - Rat delta-like 3 (Drosophila) (Dll3), 200 uL, >10^7 TU/mL

Lenti ORF particles, Dll3 (GFP-tagged ORF) - Rat delta-like 3 (Drosophila) (Dll3), 200 uL, >10^7 TU/mL  
200 µl / €1,240.00
  OriGene Technologies, Inc.

Lenti ORF particles, Dll3 (Myc-DDK-tagged ORF) - Rat delta-like 3 (Drosophila) (Dll3), 200 uL, >10^7 TU/mL

Lenti ORF particles, Dll3 (Myc-DDK-tagged ORF) - Rat delta-like 3 (Drosophila) (Dll3), 200 uL, >10^7 TU/mL  
200 µl / €1,108.00
  OriGene Technologies, Inc.

19 Item(s)

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