DNA-PKcs / PRKDC / XRCC7 antibody

Principal name

DNA-PKcs / PRKDC / XRCC7 antibody

Alternative names for DNA-PKcs / PRKDC / XRCC7 antibody

DNPK1, p460, HYRC, HYRC1, DNA-dependent protein kinase catalytic subunit

SwissProt ID

P78527 (Human), P97313 (Mouse), Q8QGX4 (Chick), Q8WN22 (Canfa), Q9DEI1 (Xenla)

Gene ID

5591 (PRKDC), 19090 (Prkdc)

Available reactivities

Hst (Hamster), Hu (Human), Ms (Mouse), Rt (Rat), Chimp (Chimpanzee), Chk (Chicken), Can (Canine), Eq (Equine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Electrophoretic Mobility Shift Assay (EMSA), Immunoprecipitation (IP), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot), Frozen Sections (C)

Background of DNA-PKcs / PRKDC / XRCC7 antibody

The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy termini that is not present in the PI 3- and PI 4-kinases. All of the members of the PIK-related kinases are also over 270 kDa. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiectases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and they display delays in p53 induction. DNA-PK is a heterotrimeric DNA binding enzyme that is composed of a large subunit, DNA-PKCS, and two smaller subunits collectively known as Ku. The loss of DNA-PK leads to defects in DSB repair and V(D)J recombination. FRAP can autophosphorylate on serine and bind to rapamycin/FKBP. FRAP is also an upstream regulator of S6 kinase and has been implicated in the regulation of p27 and p21 expression.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DNA-PKcs / PRKDC / XRCC7 antibody

  Rabbit polyclonal anti-DNA-PK antibody  
Western blot analysis of extracts from HeLa cells using DNA-PK antibody (#TA314389).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DNA-PKcs / PRKDC / XRCC7 antibody

  Mouse Monoclonal DNA-PKcs Antibody (3H6)  
Western Blot: DNA PKcs Antibody (3H6) [TA336925] - Western blot analysis using DNA PKcs mAb against HEK293 (1) and DNA PKcs(AA: 2638-2971)-hIgGFc transfected HEK293 (2) cell lysate. Mouse IgG1 3H6 Purified Hu E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DNA-PKcs / PRKDC / XRCC7 antibody

  Mouse Monoclonal DNA-PKcs Antibody  
Western blot detection of DNA-PKcs in Hela and K562 cell lysates using DNA-PKcs mouse mAb (1:1000 diluted).Predicted band size:450KDa,Observed band size:450KDa. Mouse IgG1 6D1-C11-F10 Purified ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DNA-PKcs / PRKDC / XRCC7 antibody

  Mouse Monoclonal DNA-PKcs Antibody  
Western blot detection of DNA-PKcs in Hela,K562,HL-60 and MOLT-4 cell lysates using DNA-PKcs mouse mAb (1:1000 diluted).Predicted band size:450KDa,Observed band size:450KDa. Mouse 8D3-B12-F11 Purified ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DNA-PKcs / PRKDC / XRCC7 antibody

Immunohistochemical analysis of paraffin-embedded breast cancer (left) and colon cancer (right) using PRKDC antibody Cat.-No AM06582SU-N with DAB staining. Mouse IgG1 3H6 Ascites Hu E, ICC/IF, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

DNA-PKcs / PRKDC / XRCC7 antibody

  Rabbit anti-PRKDC (DNA PKcs, Phospho-Thr2609) polyclonal antibody(Phospho-specific)  
Western blot analysis of extracts from K562 cells untreated or treated with hydroxyurea, using DNAPKcs antibody (Lanes 1 and 2) and DNA PKcs (phospho-Thr2609) antibody (Lanes 3 and 4). Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

DNA-PKcs / PRKDC / XRCC7 pThr2609 antibody

  Rabbit polyclonal DNA PKcs pT 2609 antibody  
WB using Anti-DNAPKcs antibody shows detection of a 460 kDa band corresponding to human DNAPKcs in various preparations. Lane 1: Fus1 untreated, Lane 2: Fus1 IR (20Gy, 4h), Lane 3: Fus1 DNAPK inhibitor + IR, Lane 4: MO59J (DNAPK-) untreated, Lane 5: MO59J IR, Lane 6: Fus1 untreated, Lane 7: Fus1 IR (20Gy, 4h), Lane 8: Fus1 DNAPK inhibitor + IR, Lane 9: MO59J untreated, Lane 10: MO59J IR.The primarey antibody was used at 1:1,000. Rabbit IgG Aff - Purified Can, Chimp, Chk, Eq, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

DNA-PKcs / PRKDC / XRCC7 antibody

  Anti-PRKDC Rabbit Polyclonal Antibody  
Predicted band size: 469 kDa . Positive control: HT29 and HepG2 cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1: HT29 cells lysate Lane2: HepG2 cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DNA-PKcs / PRKDC / XRCC7 antibody

  Rabbit Polyclonal Phospho-DNA-PK (Thr2647) Antibody (Phospho-specific)  
DNA-PKcs / PRKDC / XRCC7 Rabbit IgG Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

DNA-PKcs / PRKDC / XRCC7 antibody

  Mouse Monoclonal anti-DNA-PKcs Antibody  
Hela cell nuclear extracts were resolved by electrophoresis, transferred to nitrocellulose, and probed with anti-DNA-PKcs antibody (clone 7A4). Proteins were visualized using a goat anti-mouse-IgG secondary conjugated to HRP and chemiluminescence detection. Mouse IgG1 7A4 Purified Hu ICC/IF, IP, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

DNA-PKcs / PRKDC / XRCC7 antibody

  Rabbit Polyclonal Anti-DNA-PK Antibody  
Western blot analysis on HeLa cell lysate using DNA-PK Antibody Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

DNA-PKcs / PRKDC / XRCC7 antibody

  Rabbit Polyclonal Anti-DNA PK Antibody  
Western blot analysis of DNA PK expression in K562 cells Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

DNA-PKcs / PRKDC / XRCC7 antibody

Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 2A8 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

DNA-PKcs / PRKDC / XRCC7 antibody

Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG 1B9 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

DNA-PKcs / PRKDC / XRCC7 antibody

DNA-PKcs / PRKDC / XRCC7 Rabbit Aff - Purified Hst, Hu, Ms, Rt WB
0.1 mg / €390.00
  Acris Antibodies GmbH

DNA-PKcs / PRKDC / XRCC7 pThr2609 antibody

Figure 1. Western blot analysis of extract from K562 cells untreated and treated with hydroxyurea, using DNA PKcs antibody (Lane 1 and 2) and DNA PKcs (phospho-Thr2609) antibody AP02448PU (Lane 3 and 4). Rabbit Aff - Purified Hu WB
0.1 ml / €320.00
  Acris Antibodies GmbH

DNA-PKcs / PRKDC / XRCC7 pThr2609 antibody

Figure 1. Western blot analysis of extract from K562 cells untreated and treated with hydroxyurea, using DNA PKcs antibody (Lane 1 and 2) and DNA PKcs (phospho-Thr2609) antibody AP02448PU (Lane 3 and 4). Rabbit Aff - Purified Hu WB
50 µl / €240.00
  Acris Antibodies GmbH

DNA-PKcs / PRKDC / XRCC7 antibody

Western blot analysis of extract from HT29 and HepG2 cells using DNA PKcs antibody Cat.-No AP02696PU-N/PU-S Rabbit Aff - Purified Hu WB
0.1 ml / €320.00
  Acris Antibodies GmbH

DNA-PKcs / PRKDC / XRCC7 antibody

Western blot analysis of extract from HT29 and HepG2 cells using DNA PKcs antibody Cat.-No AP02696PU-N/PU-S Rabbit Aff - Purified Hu WB
50 µl / €240.00
  Acris Antibodies GmbH

DNA-PKcs / PRKDC / XRCC7 antibody

Immunohistochemical analysis in paraffin-embedded human breast carcinoma tissue using DNA-PKcs antibody (Cat.-No. AP06088PU-N). Rabbit Aff - Purified Hu, Ms E, ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

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