DNA polymerase iota antibody

Principal name

DNA polymerase iota antibody

Alternative names for DNA polymerase iota antibody

RAD30 homolog B, Eta2, POLI, RAD30B

SwissProt ID

Q6R3M4 (Mouse), Q9UNA4 (Human)

Gene ID

11201 (POLI)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoprecipitation (IP), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of DNA polymerase iota antibody

DNA polymerase activity is essential for replication, repair, recombination and mutagenesis. DNA polymerases can often bypass DNA lesions that block DNA replication, thereby allowing the replication of damaged DNA. One such DNA polymerase is the distributive enzyme DNA Pol i, which is encoded by the POLI gene. POLI is located on human chromosome 18q21.2, a region often implicated in the etiology of many human cancers. At thymine templates, DNA Pol i is highly error-prone when replicating undamaged DNA in that it favors the misincorporation of guanine over the correct nucleotide, adenosine. DNA Pol i also promotes the replication of damaged DNA by misincorporating deoxynucleotides opposite DNA lesions. DNA Pol i acts sequentially with DNA Pol Ω, which is essential for damage-induced mutagenesis, to complete the DNA lesion bypass. Therefore, replication involving DNA Pol i is likely to be highly mutagenic.

General readings

"Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa." Washington M.T., Minko I.G., Johnson R.E., Wolfle W.T., Harris T.M., Lloyd R.S., Prakash S., Prakash L. Mol. Cell. Biol. 24:5687-5693(2004) [PubMed: 15199127]

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DNA polymerase iota antibody

Western Blot: DNA Polymerase iota Antibody - Western blot analysis of DNA Polymerase iota in NIH-3T3 whole cell lysate. Rabbit Purified Hu, Ms WB
50 µl / €325.00
  OriGene Technologies, Inc.

DNA polymerase iota antibody

Western blot analysis of extracts of various cell lines, using POLI antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

DNA polymerase iota antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY POLI (RC207550, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-POLI. Mouse IgG1 OTI1H9 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

DNA polymerase iota antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-POLI mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801478) Mouse IgG1 OTI1C8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

DNA polymerase iota antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY POLI (RC207550, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-POLI. Mouse IgG1 OTI5H9 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

DNA polymerase iota antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-POLI mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801480) Mouse IgG1 OTI1B9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

DNA polymerase iota antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY POLI (RC207550, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-POLI. Mouse IgG1 OTI5D11 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

DNA polymerase iota antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY POLI (RC207550, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-POLI. Mouse IgG1 OTI5A4 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

DNA polymerase iota antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY POLI (RC207550, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-POLI. Mouse IgG1 OTI2C10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

DNA polymerase iota antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY POLI (RC207550, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-POLI. Mouse IgG1 OTI4C12 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

DNA polymerase iota antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-POLI mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801491) Mouse IgG1 OTI3B5 Purified Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

DNA polymerase iota (N-term) antibody

Human Lung; WB Suggested Anti-POLI Antibody Titration: 0.2-1 ug/ml. Positive Control: Human Lung; POLI antibody - N-terminal region (AP46109PU-N) in Human Lung cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  Acris Antibodies GmbH

DNA polymerase iota antibody

POLI monoclonal antibody (M01), clone 8G9 Western Blot analysis of POLI expression in HeLa NE ( Cat # L013V3 ). Mouse IgG3 8G9 Purified Hu E, WB
50 µg / €370.00
  Abnova Taiwan Corp.

DNA polymerase iota antibody

DNA polymerase iota Mouse IgG3 8G9 Ascites Hu E, WB
50 µg / €360.00
  Abnova Taiwan Corp.

DNA polymerase iota antibody

DNA polymerase iota Rabbit Hu, Ms WB
50 µl / €470.00
  Abnova Taiwan Corp.

DNA polymerase iota antibody

Western blot analysis of extracts from HeLa cells, using POLI Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

DNA polymerase iota antibody

Western blot analysis of extracts from HeLa cells, using POLI Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

DNA polymerase iota (N-term) antibody

Human Lung; WB Suggested Anti-POLI Antibody Titration: 0.2-1 ug/ml. Positive Control: Human Lung; POLI antibody - N-terminal region (ARP52299_P050) in Human Lung cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

DNA polymerase iota antibody

DNA polymerase iota Rabbit Purified Hu, Ms WB
25 µl / €220.00
  Novus Biologicals Inc.

DNA polymerase iota antibody

Western Blot and Immunoprecipitation: Pol Iota Antibody [NB100-60668] - Detection of Human Pol Iota on HeLa whole cell lysate using NB100-60668. Pol Iota was also immunoprecipitated by rabbit anti-Pol Iota antibody NB100-60667. Rabbit Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

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