DNAJA3 / TID1 antibody

Principal name

DNAJA3 / TID1 antibody

Alternative names for DNAJA3 / TID1 antibody

hTid-1, HCA57, DnaJ homolog subfamily A member 3 mitochondrial, umorous imaginal discs protein Tid56 homolog, DnaJ protein Tid-1, Hepatocellular carcinoma-associated antigen 57

SwissProt ID

Q96EY1 (Human), Q99M87 (Mouse)

Gene ID

9093 (DNAJA3), 83945 (Dnaja3), 2909302 (P41555)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of DNAJA3 / TID1 antibody

TID1 is a human homolog of the Drossophila tumor suppressor lethal (2) tumerous imaginal discs, l(2)tid and encodes two mitochondrial matrix localized splice variants of human Tid-1 designated hTid-1S and hTid-1L. These proteins are the conserved members of the DnaJ family of proteins which act as cochaperons for mitochondrial Hsp70. They contain a conserved tetrahedrical J domain which binds to Hsp70 chaperones and activates their ATPase activity. Expression of hTid-1L increases apoptosis induced by DNA damaging agents as mitomycin-C and TNF-α. A J-domain mutant of hTid-1L can dominantly suppress apoptosis and in sharp contrast the J-domain mutant of hTid-1S increases apoptosis. Expression of hTid-1S and hTid-1L affects cytochrome c release from the mitochondria and caspase 3 activation, while activation of caspase 8 is unaffected. It is strongly suggested that these two splice variants exert their anti- and pro- apoptotic effects through discrete substrates and actiuvities. Hence the relative abundance of these proteins or their substrates may allow the mitochondria to dampen or enhance the apoptotic signals.

General readings

Qian, J., et al. Gastroenterology 138(4):1418-1428 (2010).
Kurzik-Dumke, U., et al. J Transl Med 8, 58 (2010).
Linnoila, J., et al. Neuron 60(4):625-641 (2008).
Kurzik-Dumke, U., et al. Int. J. Mol. Med. 21(1):19-31 (2008)
Kurzik-Dumke, U., et al. Cell. Signal. 19(9):1973-1985 (2007).

11 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DNAJA3 / TID1 (C-term) antibody

Skeletal muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

DNAJA3 / TID1 (N-term) antibody

Western blot analysis of DNAJA3 / TID1 Antibody (N-term) Cat.-No AP51285PU-N in Hela cell line lysates (35ug/lane). This demonstrates the DNAJA3 antibody detected the DNAJA3 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

DNAJA3 / TID1 antibody

Immunofluorescence of purified MaxPab antibody to DNAJA3 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Serum Hu E(detection), ICC/IF, WB
50 µl / €370.00
  Abnova Taiwan Corp.

DNAJA3 / TID1 antibody

Immunofluorescence of purified MaxPab antibody to DNAJA3 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

DNAJA3 / TID1 antibody

DNAJA3 / TID1 Rabbit Hu, Ms E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

DNAJA3 / TID1 antibody

DNAJA3 / TID1 Rabbit IgG Hu ICC/IF, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

DNAJA3 / TID1 antibody

Immunohistochemistry-Paraffin: TID1 Antibody [NBP1-39496] - DNAJA3 / TID1 antibody (10 ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human skeletal muscle, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Hu, Ms E, P, WB
50 µg / €480.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

DNAJA3 / TID1 (transcript variant 1)

DNAJA3 / TID1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

DNAJA3 / TID1

DNAJA3 / TID1 Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

DNAJA3 / TID1

DNAJA3 / TID1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

DNAJA3 / TID1

DNAJA3 / TID1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

11 Item(s)

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