DOCK1 / DOCK180 antibody

Principal name

DOCK1 / DOCK180 antibody

Alternative names for DOCK1 / DOCK180 antibody

Dedicator of cytokinesis protein 1, 180 kDa protein downstream of CRK

SwissProt ID

Q14185 (Human), Q8BUR4 (Mouse)

Gene ID

1793 (DOCK1), 330662 (Dock1)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Por (Porcine), Rt (Rat)

Available hosts

Goat, Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of DOCK1 / DOCK180 antibody

The v-Crk oncogene product shares homologous amino acid sequences, designated Src homology region 2 (SH2) and SH3, with many molecules involved in signal transduction. The v-Crk cellular homolog, c-Crk, is a member of a newly emerging class of genes including Nck and GRB2/ASH which encode proteins that consist primarily of SH2 and SH3 domains. Two distinct human c-Crk cDNAs, designated Crk I and Crk II, have been identified and shown to represent alternative splice products of c-Crk. The major translational product of c-Crk I has been identified as a 28 kDa variably expressed protein, while c-Crk II encodes a widely expressed 40 kDa protein and a more variably expressed 42 kDa protein.
The major c-Crk transforming activity appears associated with c-Crk I p28 expression. DOCK 180, a 180 kDa protein downstream of Crk, has been identified as a major Crk-associated protein. When DOCK 180 is recruited to the plasma membrane from a cytoplasmic reservoir, presumably by Crk, changes in cellular morphology and spindle formation occur, suggesting DOCK 180 to be a Crk effector molecule.

General readings

Hasegawa H, Kiyokawa E, Tanaka S, Nagashima K, Gotoh N, Shibuya M, Kurata T, Matsuda M.
DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane.
Mol Cell Biol 1996 Apr;16(4):1770-6
PMID: 8657152

15 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DOCK1 / DOCK180 (C-term) antibody

  Goat Polyclonal Antibody against DOCK1  
TA302729 staining (4µg/ml) of A431 lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 12 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

DOCK1 / DOCK180 antibody

  Rabbit Polyclonal antibody to DOCK1 (dedicator of cytokinesis 1)  
Sample(30 ug of whole cell lysate). A:293T. 7.5% SDS PAGE. TA308798 diluted at 1:1000 Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DOCK1 / DOCK180 antibody

  Rabbit polyclonal anti-DOCK1 antibody  
Western blot analysis of extracts from HeLa cells, using DOCK1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DOCK1 / DOCK180 antibody

  Rabbit Polyclonal Anti-DOCK1 Antibody  
DOCK1 / DOCK180 Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

DOCK1 / DOCK180 antibody

Western blot (WB) analysis of DOCK 180 antibody (Cat.-No.: AP21159PU-N) in extracts from HUVEC cells. Rabbit Aff - Purified Hu, Ms WB
0.1 mg / €350.00
  Acris Antibodies GmbH

DOCK1 / DOCK180 antibody

Western blot analysis of extracts from HeLa cells, using DOCK1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €230.00
  Assay Biotech

DOCK1 / DOCK180 antibody

Western blot analysis of extracts from HeLa cells, using DOCK1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

DOCK1 - human gene knockout kit via CRISPR

DOCK1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

DOCK1 - human gene knockout kit via CRISPR

DOCK1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

DOCK1 - human gene knockout kit via CRISPR

DOCK1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

DOCK1 - human gene knockout kit via CRISPR

DOCK1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dock1 - mouse gene knockout kit via CRISPR

Dock1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Dock1 - mouse gene knockout kit via CRISPR

Dock1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dock1 - mouse gene knockout kit via CRISPR

Dock1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dock1 - mouse gene knockout kit via CRISPR

Dock1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

15 Item(s)

per page
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