DOCK5 antibody

Principal name

DOCK5 antibody

Alternative names for DOCK5 antibody

Dedicator of cytokinesis protein 5

SwissProt ID

B2RY04 (Mouse), Q9H7D0 (Human)

Gene ID

80005 (DOCK5)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Enzyme Immunoassay (E)

Background of DOCK5 antibody

DOCK 5 (dedicator of cytokinesis protein 5) is a 1,870 amino acid protein belonging to the DOCK family of cytokinesis-regulating proteins. This cytoplasmic peripheral membrane protein activates Rac 1 and Rac 2 small GTPases, while presumably acting as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. DOCK 5 contains one DHR-1 (CZH-1) domain, one DHR-2 (CZH-2) domain and one SH3 domain. The DHR-2 domain is a putative GEF activity mediator. In mice, spontaneous mutation of the gene encoding DOCK 5 leads to deletion of the DHR-1 domain, which functions to bind phospholipids and assists in protein-protein interactions, resulting in rupture of lens cataract (RLC). Due to siRNA knockdown studies, it is suspected that DOCK 5 may also be an important mediator of CrkII/CrkL regulation of Caco-2 migration and spreading on COL4. There are two isoforms of DOCK 5 that exist as a result of alternative splicing events.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DOCK5 antibody

DOCK5 Rabbit Serum Hu, Ms C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

DOCK5 antibody

DOCK5 Rabbit Serum Hu, Ms P, WB
0.2 ml / €400.00
  Novus Biologicals Inc.

DOCK5 antibody

Immunohistochemistry-Paraffin: Dock5 Antibody [NBP1-83627] - Immunohistochemical staining of human tonsil shows distinct cytoplasmic positivity in lymphoid cells. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

DOCK5

DOCK5 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

DOCK5

DOCK5 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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