DOCK5 antibody

Principal name

DOCK5 antibody

Alternative names for DOCK5 antibody

Dedicator of cytokinesis protein 5

SwissProt ID

B2RY04 (Mouse), Q9H7D0 (Human)

Gene ID

80005 (DOCK5)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of DOCK5 antibody

DOCK 5 (dedicator of cytokinesis protein 5) is a 1,870 amino acid protein belonging to the DOCK family of cytokinesis-regulating proteins. This cytoplasmic peripheral membrane protein activates Rac 1 and Rac 2 small GTPases, while presumably acting as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. DOCK 5 contains one DHR-1 (CZH-1) domain, one DHR-2 (CZH-2) domain and one SH3 domain. The DHR-2 domain is a putative GEF activity mediator. In mice, spontaneous mutation of the gene encoding DOCK 5 leads to deletion of the DHR-1 domain, which functions to bind phospholipids and assists in protein-protein interactions, resulting in rupture of lens cataract (RLC). Due to siRNA knockdown studies, it is suspected that DOCK 5 may also be an important mediator of CrkII/CrkL regulation of Caco-2 migration and spreading on COL4. There are two isoforms of DOCK 5 that exist as a result of alternative splicing events.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DOCK5 antibody

DOCK5 Rabbit Serum Hu, Ms C, E, WB
0.2 ml / €400.00
  OriGene Technologies GmbH

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