DOK2 / p56 dok2 antibody

Principal name

DOK2 / p56 dok2 antibody

Alternative names for DOK2 / p56 dok2 antibody

p56(dok-2), p56Dok-2, Docking protein 2, Downstream of tyrosine kinase 2

SwissProt ID

A7MBB8 (Bovin), O60496 (Human), O70469 (Mouse)

Gene ID

9046 (DOK2)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Frozen Sections (C), Immunoprecipitation (IP), Flow Cytometry (F)

Background of DOK2 / p56 dok2 antibody

Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. Dok-2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. Dok-2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung. Expression of bcr/abl induces additional tyrosine phosphorylation of the Dok1 and Dok2 proteins and their association with Ras-GAP. Thus, it is suspected that DOK association regulates GAP activity toward Ras and that the Dok proteins serve as mediators of bcr-abl signaling. The role of Dok proteins in bcr-abl regulation may also be implicated in chronic myelogenous leukemia (CML), which is characterized by a Philadelphia chromosome translocation t(9;22). Such a mutation would result in a p210-bcr/abl chimeric protein-tyrosine kinase which has been found in many CML cases.

General readings

Boulay,I., et al., (2005) J. Immunol. 175 (7), 4483-4489

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DOK2 / p56 dok2 antibody

Human Breast ca stained with Anti-DOK2 Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

DOK2 / p56 dok2 antibody

Human Breast ca stained with Anti-DOK2 Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

DOK2 / p56 dok2 antibody

Human Breast ca stained with Anti-DOK2 Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

DOK2 / p56 dok2 antibody

Western blot analysis of extracts from K562 cells, using p56Dok-2 antibody (Lanes 1 and 2) and p56Dok-2 (phospho-Tyr299) antibody (Lanes 3 and 4). Rabbit IgG Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

DOK2 / p56 dok2 antibody

Western blot analysis of p56 Dok-2 expression in K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DOK2 / p56 dok2 antibody

Anti-DOK2 mouse monoclonal antibody (TA503158) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY DOK2(RC207621). Mouse IgG1 OTI1A4 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

DOK2 / p56 dok2 antibody

Anti-DOK2 mouse monoclonal antibody (TA503302) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY DOK2(RC207621). Mouse IgG2a OTI2A3 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

DOK2 / p56 dok2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOK2 (RC207621, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DOK2. Mouse IgG1 OTI1G9 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

DOK2 / p56 dok2 antibody

Anti-DOK2 mouse monoclonal antibody (TA503337) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY DOK2(RC207621). Mouse IgG1 OTI3D6 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

DOK2 / p56 dok2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOK2 (RC207621, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DOK2. Mouse IgG1 OTI2D10 Purified Can, Hu, Mky, Ms, Rt WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

DOK2 / p56 dok2 pTyr299 antibody

Figure 1. Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue, using p56Dok-2 pTyr299 antibody AP02521PU. Rabbit Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

DOK2 / p56 dok2 pTyr299 antibody

Figure 1. Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue, using p56Dok-2 pTyr299 antibody AP02521PU. Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µl / €240.00
  Acris Antibodies GmbH

DOK2 / p56 dok2 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p56Dok-2 antibody. Rabbit Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

DOK2 / p56 dok2 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p56Dok-2 antibody. Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

DOK2 / p56 dok2 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

DOK2 / p56 dok2 antibody

Immunohistochemistry (IHC) analyzes of Dok-2 antibody (Cat.-No.: AP20563PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

DOK2 / p56 dok2 pTyr299 antibody

Western blot (WB) analyzes of p-Dok-2 antibody (Cat.-No.: AP20861PU-N) in extracts from 293 serum cells. Rabbit Aff - Purified Hu, Ms ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

DOK2 / p56 dok2 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with DOK2 polyclonal antibody ( Cat # PAB3407 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

DOK2 / p56 dok2 antibody

Imunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using DOK2 polyclonal antibody ( Cat # PAB7679 ). Rabbit Hu ICC/IF, P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

DOK2 / p56 dok2 antibody

Immunohistochemical staining of DOK2 on formalin fixed, paraffin embedded human breast cancer with DOK2 polyclonal antibody. Rabbit Hu P
0.1 ml / €390.00
  Abnova Taiwan Corp.

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