DOK2 / p56 dok2 antibody

Principal name

DOK2 / p56 dok2 antibody

Alternative names for DOK2 / p56 dok2 antibody

p56(dok-2), p56Dok-2, Docking protein 2, Downstream of tyrosine kinase 2

SwissProt ID

A7MBB8 (Bovin), O60496 (Human), O70469 (Mouse)

Gene ID

9046 (DOK2), 13449 (Dok2)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Immunoprecipitation (IP), Flow Cytometry (F)

Background of DOK2 / p56 dok2 antibody

Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. Dok-2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. Dok-2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung. Expression of bcr/abl induces additional tyrosine phosphorylation of the Dok1 and Dok2 proteins and their association with Ras-GAP. Thus, it is suspected that DOK association regulates GAP activity toward Ras and that the Dok proteins serve as mediators of bcr-abl signaling. The role of Dok proteins in bcr-abl regulation may also be implicated in chronic myelogenous leukemia (CML), which is characterized by a Philadelphia chromosome translocation t(9;22). Such a mutation would result in a p210-bcr/abl chimeric protein-tyrosine kinase which has been found in many CML cases.

General readings

Boulay,I., et al., (2005) J. Immunol. 175 (7), 4483-4489

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DOK2 / p56 dok2 antibody

  DOK2 mouse monoclonal antibody, clone OTI2D10 (formerly 2D10)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOK2 (RC207621, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DOK2. Mouse IgG1 OTI2D10 Purified Can, Hu, Mky, Ms, Rt WB
0.1 ml / €379.00
  OriGene Technologies, Inc.


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