Dopamine D4 receptor antibody

Principal name

Dopamine D4 receptor antibody

Alternative names for Dopamine D4 receptor antibody

DRD4, D(2C) dopamine receptor, D(4) dopamine receptor

SwissProt ID

P21917 (Human), P30729 (Rat), P51436 (Mouse)

Gene ID

1815 (DRD4), 25432 (Drd4), 13491

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Can (Canine), Eq (Equine), Ft (Ferret), Hst (Hamster), Mky (Monkey), Por (Porcine), Prim (Primate), Bear

Available hosts

Rabbit, Goat

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Dot blot (Dot), Immunoprecipitation (IP), Paraffin Sections (P)

Background of Dopamine D4 receptor antibody

The Dopamine neurotransmitter belongs to catecholamines and can therefore be further converted into adreline and noreadreline. Dopamine has various physiological roles, including learning and memory, motor output and endocrine regulation. It does so by binding and activating Dopamine receptors which belong to the G-protein coupled receptor superfamily (GPCR). The D4 Dopamine Receptor belongs to the D2-like family as do D2 and D3 Dopamine Receptors and like all GPCRs has seven transmembrane spanning membrane regions. Structure wise members of the family share high homology in the transmembrane domains and lower homology in the extracellular N-Termil and the intracellular C-termil domains. Notably, the coding region of the 3rd intracellular loop of D4 Receptor is known to undergo extensive polymorphism. Like many GPCRs, each dopamine receptor subtype can react with more than one G-protein giving rise to different sigling possibilities. Whereas D2-like dopamine receptors are generally considered to couple to Gi, and therefore inhibit adenylyl cyclase, the sigling through D4 is complicated due to the polymorphisms in the 3rd intracellular loop. It seems that this region is important to G-coupling as different polyphormisms in the region influence the ability of D4 to couple to adenylyl cyclase and G-proteins. D4 Dopamine Receptors also influence Ca2+ levels. They could also interact with G-protein couple inwardly rectifying K+ channel to ultimately cause a decrease in the firing rate of neurons. The distribution of D4 Dopamine Receptor mostly includes the brain and is mainly found post-syptically in dendritic shafts and spines of mammalian striatum.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Dopamine D4 receptor (C-term) antibody

  Rabbit Polyclonal Anti-DRD4 Antibody (C-Terminus)  
Anti-DRD4 / Dopamine Receptor D4 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Elephant, Eq, Ft, Hst, Hu, Mky, Por, Prim P
50 µg / €400.00
  OriGene Technologies, Inc.

Dopamine D4 receptor antibody

  Rabbit polyclonal anti-DRD4 antibody  
Western blot analysis of extracts from MCF-7 cells and HUVEC cells, using DRD4 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Dopamine D4 receptor antibody

  Anti-DRD4 Rabbit Polyclonal Antibody  
Western blot analysis of Human liver cancer tissue using TA321201(DRD4 Antibody) at dilution 1/600 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Dopamine D4 receptor antibody

  Anti-DRD4 Rabbit Polyclonal Antibody  
Predicted band size: 48kDa. Positive control: Mouse skeletal muscle tissue lysate . Recommended dilution: 1/500-1000 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Dopamine D4 receptor antibody

  Rabbit Polyclonal Anti-D4 Dopamine Receptor  
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain lysates: 1, 2. Anti-D4 Dopamine Receptor antibody, (1:200). 3, 4. Anti-D4 Dopamine Receptor antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Dopamine D4 receptor antibody

Western blot analysis of D4DR antibody (Cat.-No.: AP01422PU-N) in extracts from HeLa cells at 1/500 dilution. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Dopamine D4 receptor (Center) antibody

Western blot analysis of DRD4 Antibody (Center) (AP17995PU-N) in mouse heart tissue lysates (35ug/lane). DRD4 (arrow) was detected using the purified Pab. Rabbit Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Dopamine D4 receptor antibody

Dopamine D4 receptor Rabbit Serum Hu, Rt C, E, ICC/IF, WB
0.1 ml / €560.00
  Acris Antibodies GmbH

Dopamine D4 receptor antibody

Immunofluorescence analysis of MCF7 cells, using DRD4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €230.00
  Assay Biotech

Dopamine D4 receptor antibody

Immunofluorescence analysis of MCF7 cells, using DRD4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

DRD4 - human gene knockout kit via CRISPR

DRD4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

DRD4 - human gene knockout kit via CRISPR

DRD4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

DRD4 - human gene knockout kit via CRISPR

DRD4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

DRD4 - human gene knockout kit via CRISPR

DRD4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Drd4 - mouse gene knockout kit via CRISPR

Drd4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Drd4 - mouse gene knockout kit via CRISPR

Drd4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Drd4 - mouse gene knockout kit via CRISPR

Drd4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Drd4 - mouse gene knockout kit via CRISPR

Drd4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, DRD4 (Myc-DDK tagged) - Human dopamine receptor D4 (DRD4), 200 uL, >10^7 TU/mL

Lenti ORF particles, DRD4 (Myc-DDK tagged) - Human dopamine receptor D4 (DRD4), 200 uL, >10^7 TU/mL  
200 µl / €900.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Drd4 (GFP-tagged) - Mouse dopamine receptor D4 (Drd4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Drd4 (GFP-tagged) - Mouse dopamine receptor D4 (Drd4), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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