DPP8 / DPRP1 antibody

Principal name

DPP8 / DPRP1 antibody

Alternative names for DPP8 / DPRP1 antibody

MSTP097, MSTP135, MSTP141, Dipeptidyl peptidase 8, DPPVIII, Dipeptidyl peptidase VIII, DP8, Prolyl dipeptidase DPP8, Dipeptidyl peptidase IV-related protein 1

SwissProt ID

Q6V1X1 (Human), Q80YA7 (Mouse)

Gene ID

54878 (DPP8)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot)

Background of DPP8 / DPRP1 antibody

DPP8 (Dipeptidyl Peptidase-8) is a serine proteinase of the clan SC. The clan SC proteinases have a catalytic triad of Ser-Asp-His, and like other Serine proteinases, the active site serine is in a Gly-Xaa-Ser-Xaa -Gly orientation. DPP8 is a member of a broader family of dipeptidyl peptidases including DPP2, DPP4, FAP/Seprase, DPP6, DPP9, DPP10, which have differing substrate specificity and tissue localizations. DPP8 is most closely related to DPP9, with which it shares 58% identical residues. DPP8 has only 27% identity with DPP4, but seems to have similar substrate specificity. Although DPP4 and FAPa form a surface-bound heterodimer in some cells, and homodimers in others, DPP8 seems to be a cytoplasmic protein. The original publication determined that DPP8 was a monomer, active at neutral pH, and later publications suggest DPP-8 is a homodimer. Substrates include glucagon-like peptide-1, glucagon-like peptide-2, neuropeptide-Y, but with different efficacy relative to DPP4. DPP8 has been found in highest abundance in the testis and placenta, but is found in most tissues. Several different splice variants of DPP8 were seen in the different tissues, with some tissue-specific expression. Four different human sequences are reported to date; 898, 882, 847 and 782 amino acids in length. The longest sequence of human DPP8 has a predicted mass of 103.4 kDa, and pI of 5.42. The 882, 847 and 782 amino acid forms are predicted at 101.4, 97.5 and 89.9 kDa respectively, with pIs of 5.26, 5.55 and 5.07. Another three partial sequences that are alternatively spliced have deletions in the catalytic domain, and may not be catalytically active. Over expression of DPP8 caused decreased viability in cells, but a catalytically dead mutant of DPP8 had the same results, thus some of the DPP8 activity may be non-enzymatic. Two of the splice variants have longer aminotermini (16 AA insert), and this may affect localization in the cell.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DPP8 / DPRP1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-DPP8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504366) Mouse IgG1 OTI1D2 Purified Can, Hu, Ms, Rt P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

DPP8 / DPRP1 antibody

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

DPP8 / DPRP1 antibody

Sample (30 ug of whole cell lysate). A: A431 . 7.5% SDS PAGE. DPP8 antibody. TA308193 diluted at 1:1000. Rabbit IgG Aff - Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DPP8 / DPRP1 antibody

Sample (30 ug of whole cell lysate). A: A549. 7.5% SDS PAGE. TA308446 diluted at 1:1000. Rabbit IgG Aff - Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DPP8 / DPRP1 (N-term) antibody

Uterus: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bear, Bov, Bt, Can, Chk, Elephant, Eq, Hu, Mky, Ms, Op, Por, Prim, Rb, Rt, Tr P
50 µg / €470.00
  Acris Antibodies GmbH

DPP8 / DPRP1 (Internal) antibody

Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval using Anti-DPP8 antibody AP07042PU-N of human uterus, endometrial glands. Rabbit Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, Hu, Mky, Ms, Op, Por, Prim, Rb, Rt P
50 µg / €470.00
  Acris Antibodies GmbH

DPP8 / DPRP1 (Internal) antibody

Uterus: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, Hu, Mky, Ms, Op, Por, Prim, Rb, Rt P
50 µg / €470.00
  Acris Antibodies GmbH

DPP8 / DPRP1 (C-term) antibody

Western blot analysis of DPP8 antibody (C-term) (AP17292PU-N) in 293 cell line lysates (35 µg/lane). DPP8 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

DPP8 / DPRP1 antibody

Western Blot analysis of DPP8 expression in transfected 293T cell line (H00054878-T01) by DPP8 MaxPab polyclonal antibody.

Lane 1: DPP8 transfected lysate(98.78 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

DPP8 / DPRP1 antibody

DPP8 / DPRP1 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

DPP8 / DPRP1 antibody

DPP8 / DPRP1 Mouse IgG2a 1B10 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

DPP8 / DPRP1 antibody

DPP8 / DPRP1 Rabbit IgG Aff - Purified Hu P
50 µg / €440.00
  Novus Biologicals Inc.

DPP8 / DPRP1 antibody

Immunofluorescence: DPP8 Antibody [NBP1-31256] - Immunofluorescence analysis of HeLa, using DPRP1 antibody at 1:200 dilution. Rabbit IgG Hu Dot, ICC/IF, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

DPP8 / DPRP1 antibody

Immunohistochemistry-Paraffin: DPP8 Antibody [NBP1-84993] - Immunohistochemical staining of human duodenum shows strong cytoplasmic and membranous positivity in glandular cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

DPP8 / DPRP1 (transcript variant 1)

DPP8 / DPRP1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

DPP8 / DPRP1

DPP8 / DPRP1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

DPP8 / DPRP1

DPP8 / DPRP1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

DPP8 / DPRP1

DPP8 / DPRP1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

DPP8 / DPRP1

DPP8 / DPRP1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

DPP8 293T Cell Transient Overexpression Lysate(Denatured)

DPP8 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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