DPYD antibody

Principal name

DPYD antibody

Alternative names for DPYD antibody

DHPDHase, DPD, Dihydrouracil dehydrogenase, Dihydrothymine dehydrogenase, Dihydropyrimidine dehydrogenase [NADP+]

SwissProt ID

O89000 (Rat), Q12882 (Human), Q28007 (Bovin), Q28943 (Pig), Q8CHR6 (Mouse), Q96TH1 (Human)

Gene ID

1806 (DPYD), 99586 (Dpyd), 81656

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of DPYD antibody

DPYD(Dihydropyrimidine Dehydrogenase), also called DPD, is an enzyme that in humans is encoded by the DPYD gene. The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. The structure of the DPYD gene contains 23 exons spanning about 950 kb. Using somatic cell hybrid strategies, the DPYD gene is mapped to the centromeric region of chromosome 1 between 1p22 and 1q21. By fluorescence in situ hybridization, the DPYD gene is mapped to 1p22. The highest level of DPD was found in monocytes followed by that in lymphocytes, granulocytes, and platelets, whereas no significant activity of DPD could be detected in erythrocytes. The activity of DPD in peripheral blood mononuclear cells was intermediate between that observed in monocytes and lymphocytes. By cDNA microarray, Western blot analysis, and luciferase reporter assay, the transcription factor LSF was identified as a positive regulator of DPYD.

General readings

Albin, N., Johnson, M. R., Shahinian, H., Wang, K., Diasio, R. B. Initial characterization of the
molecular defect in human dihydropyrimidine dehydrogenase deficiency. Proc. Am. Assoc. Cancer
Res. (Abstract) 36: 211 only, 1995.
2. McLeod, H. L., Collie-Duguid, E. S. R., Vreken, P., Johnson, M. R., Wei, X., Sapone, A., Diasio, R.
B., Fernandez-Salguero, P., van Kuilenberg, A. B. P., van Gennip, A. H., Gonzales, F.
J. Nomenclature for human DPYD alleles. Pharmacogenetics 8: 455-459, 1998.
3. Ridge, S. A., Brown, O., McMurrough, J., Fernandez-Salguero, P., Evans, W. E., Gonzalez, F. J.,
McLeod, H. L. Mutations at codon 974 of theDPYD gene are a rare event. Brit. J. Cancer 75:
178-179, 1997.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DPYD antibody

  DPYD Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using DPYD antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

DPYD antibody

  Rabbit polyclonal antibody to DPYD (dihydropyrimidine dehydrogenase)  
Sample (30 ug of whole cell lysate). A: Raji. B: K562. C: NCI-H929. 7.5% SDS PAGE. TA308200 diluted at 1:1000. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

DPYD - human gene knockout kit via CRISPR

DPYD - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

DPYD - human gene knockout kit via CRISPR

DPYD - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

DPYD - human gene knockout kit via CRISPR

DPYD - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

DPYD - human gene knockout kit via CRISPR

DPYD - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dpyd - mouse gene knockout kit via CRISPR

Dpyd - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Dpyd - mouse gene knockout kit via CRISPR

Dpyd - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dpyd - mouse gene knockout kit via CRISPR

Dpyd - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dpyd - mouse gene knockout kit via CRISPR

Dpyd - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

DPYD

  Recombinant protein of human dihydropyrimidine dehydrogenase (DPYD)  
DPYD Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

DPYD overexpression lysate

DPYD overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, DPYD (mGFP-tagged) - Human dihydropyrimidine dehydrogenase (DPYD), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, DPYD (mGFP-tagged) - Human dihydropyrimidine dehydrogenase (DPYD), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, DPYD (mGFP-tagged)-Human dihydropyrimidine dehydrogenase (DPYD), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, DPYD (mGFP-tagged)-Human dihydropyrimidine dehydrogenase (DPYD), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, DPYD (Myc-DDK tagged) - Human dihydropyrimidine dehydrogenase (DPYD), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, DPYD (Myc-DDK tagged) - Human dihydropyrimidine dehydrogenase (DPYD), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Lenti ORF particles, DPYD (Myc-DDK-tagged)-Human dihydropyrimidine dehydrogenase (DPYD), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, DPYD (Myc-DDK-tagged)-Human dihydropyrimidine dehydrogenase (DPYD), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Dpyd (GFP-tagged) - Mouse dihydropyrimidine dehydrogenase (Dpyd), 200 uL, >10^7 TU/mL

Lenti ORF particles, Dpyd (GFP-tagged) - Mouse dihydropyrimidine dehydrogenase (Dpyd), 200 uL, >10^7 TU/mL  
200 µl / €1,810.00
  OriGene Technologies, Inc.

Lenti ORF particles, Dpyd (Myc-DDK-tagged) - Mouse dihydropyrimidine dehydrogenase (Dpyd), 200 uL, >10^7 TU/mL

Lenti ORF particles, Dpyd (Myc-DDK-tagged) - Mouse dihydropyrimidine dehydrogenase (Dpyd), 200 uL, >10^7 TU/mL  
200 µl / €1,630.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Dpyd (GFP-tagged ORF) - Rat dihydropyrimidine dehydrogenase (Dpyd), 200 uL, >10^7 TU/mL

Lenti ORF particles, Dpyd (GFP-tagged ORF) - Rat dihydropyrimidine dehydrogenase (Dpyd), 200 uL, >10^7 TU/mL  
200 µl / €2,150.00
  OriGene Technologies, Inc.

Lenti ORF particles, Dpyd (Myc-DDK-tagged ORF) - Rat dihydropyrimidine dehydrogenase (Dpyd), 200 uL, >10^7 TU/mL

Lenti ORF particles, Dpyd (Myc-DDK-tagged ORF) - Rat dihydropyrimidine dehydrogenase (Dpyd), 200 uL, >10^7 TU/mL  
200 µl / €1,939.00
  OriGene Technologies, Inc.

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