DPYSL2 / CRMP2 antibody

Principal name

DPYSL2 / CRMP2 antibody

Alternative names for DPYSL2 / CRMP2 antibody

Dihydropyrimidinase-related protein 2, DRP-2, N2A3, Collapsin response mediator protein 2

SwissProt ID

O02675 (Bovin), O08553 (Mouse), P47942 (Rat), Q16555 (Human), Q90635 (Chick)

Gene ID

1808 (DPYSL2), 12934 (Dpysl2), 25416

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Ze (Zebrafish), African clawed frog

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C)

Background of DPYSL2 / CRMP2 antibody

DRP-2, also known as collapsin response mediator protein-2 (CRMP-2), is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity (1,2). CRMP-2 enhances axon elongation and branching by binding to tubulin heterodimers to promote microtubule assembly (3). GSK-3β inactivates CRMP-2 by phosphorylating it at Thr514. CRMP-2 is primed following phosphorylation at Ser522 by CDK5 and at Thr518 by GSK-3β (2). Phosphorylation of CRMP-2, which decreases tubulin binding ability, can be inhibited by NT-3 and BDNF through the PI3 kinase/Akt pathway (2). CRMP-2 also mediates semaphorin-induced growth cone collapse (4). Hyperphosphorylation of CRMP-2 and is found in Alzheimer disease plaques with concurrent elevated GSK-3β activity in these patients (5).

General readings

1. Greene ND, Bamidele A, Choy M, de Castro SC, Wait R, Leung KY, et al. Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine-induced model of convulsive status epilepticus. Proteomics. 2007 Apr;7(8):1336-44. PubMed PMID: 17366478. 
2. Veyrac A. et al. Expression of collapsin response mediator proteins 1, 2 and 5 is differentially regulated in newly generated and mature neurons of the adult olfactory system. Eur J Neurosci. 2005;21:2635-48.
3. Bertin S. et al. Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain. J Comp Neurol. 2005;486:1-17.
4. Quach T. et al. Involvement of collapsin response mediator proteins in the neurite extension induced by neurotrophins in dorsal root ganglion neurons. Mol Cell Neurosci. 2004;25:433-43.
5. Charrier E. et al. Collapsin response mediator proteins (CRMPs): involvement in nervous system
development and adult neurodegenerative disorders. Mol Neurobiol. 2003;28:51-64. Review.
6. Ricard D et al. Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin
response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes. J Neurosci. 2001 ; 21:7203-14.
7. Honnorat J. et al. Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes. Eur J Neurosci. 1999;11:4226-32.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DPYSL2 / CRMP2 (C-term) antibody

Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

DPYSL2 / CRMP2 antibody

Western blot analysis of extracts from HT-29 cells, treated with heat shock, using CRMP-2 (Ab-509) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DPYSL2 / CRMP2 antibody

Western blot analysis of extracts from HepG2 cells, Jurkatcells and 293 cells, using CRMP-2 (Ab-522)antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DPYSL2 / CRMP2 antibody

Western blot analysis of extracts from A549 cells, treated with EGF (200ng/ml, 30mins), using DRP-2 (Ab-514) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DPYSL2 / CRMP2 antibody

Predicted band size: 62kDa. Positive control: NIH/3T3 cell lysate . Recommended dilution: 1/200-1000 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DPYSL2 / CRMP2 antibody

Predicted cell location: Cytoplasm . Positive control: Human liver cancer tissue. Recommended dilution: 1/50-300  The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using DPYSL2 antibody at dilution 1/25, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

DPYSL2 / CRMP2 antibody

Western blot analysis of DRP-2 expression in EGF treated A549 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DPYSL2 / CRMP2 antibody

Western blot analysis of DRP-2 phosphorylation expression in PMA treated NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DPYSL2 / CRMP2 antibody

Immunohistochemistry: AM11031SU-N DPYSL2 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Testis followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG2b 33CT11.40.3 Ascites Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

DPYSL2 / CRMP2 pSer465 antibody

DPYSL2 / CRMP2 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

DPYSL2 / CRMP2 antibody

Distribution patternof CRMP2 in olfactory receptor neurons within the olfactory mucosa Rabbit Serum Ms C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

DPYSL2 / CRMP2 pThr509 antibody

Immunohistochemical analysis of paraffin-embedded human brain tissue using CRMP-2 (Phospho-Thr509) antibody AP55813PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €340.00
  Acris Antibodies GmbH

DPYSL2 / CRMP2 pThr509 antibody

Immunohistochemical analysis of paraffin-embedded human brain tissue using CRMP-2 (Phospho-Thr509) antibody AP55813PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µl / €270.00
  Acris Antibodies GmbH

DPYSL2 / CRMP2 pSer522 antibody

Western blot analysis of extracts from HuvEc cells (Lane 2), using CRMP-2 (Phospho-Ser522) Antibody AP55854PU-N. The lane on the left is treated with antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €340.00
  Acris Antibodies GmbH

DPYSL2 / CRMP2 pSer522 antibody

Western blot analysis of extracts from HuvEc cells (Lane 2), using CRMP-2 (Phospho-Ser522) Antibody AP55854PU-N. The lane on the left is treated with antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / €270.00
  Acris Antibodies GmbH

DPYSL2 / CRMP2 antibody

DPYSL2 / CRMP2 Mouse IgG2a 1F11 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

DPYSL2 / CRMP2 antibody

DPYSL2 / CRMP2 Rabbit Hu, Ms, Rt E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

DPYSL2 / CRMP2 pThr514 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using DRP-2 (Phospho-Thr514) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech

DPYSL2 / CRMP2 pThr514 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using DRP-2 (Phospho-Thr514) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €310.00
  Assay Biotech

DPYSL2 / CRMP2 pThr509 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using CRMP-2 (Phospho-Thr509) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

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