DPYSL2 / CRMP2 antibody

Principal name

DPYSL2 / CRMP2 antibody

Alternative names for DPYSL2 / CRMP2 antibody

Dihydropyrimidinase-related protein 2, DRP-2, N2A3, Collapsin response mediator protein 2

SwissProt ID

O02675 (Bovin), O08553 (Mouse), P47942 (Rat), Q16555 (Human), Q90635 (Chick)

Gene ID

1808 (DPYSL2), 12934 (Dpysl2), 25416

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Ze (Zebrafish), African clawed frog

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C)

Background of DPYSL2 / CRMP2 antibody

DRP-2, also known as collapsin response mediator protein-2 (CRMP-2), is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity (1,2). CRMP-2 enhances axon elongation and branching by binding to tubulin heterodimers to promote microtubule assembly (3). GSK-3β inactivates CRMP-2 by phosphorylating it at Thr514. CRMP-2 is primed following phosphorylation at Ser522 by CDK5 and at Thr518 by GSK-3β (2). Phosphorylation of CRMP-2, which decreases tubulin binding ability, can be inhibited by NT-3 and BDNF through the PI3 kinase/Akt pathway (2). CRMP-2 also mediates semaphorin-induced growth cone collapse (4). Hyperphosphorylation of CRMP-2 and is found in Alzheimer disease plaques with concurrent elevated GSK-3β activity in these patients (5).

General readings

1. Greene ND, Bamidele A, Choy M, de Castro SC, Wait R, Leung KY, et al. Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine-induced model of convulsive status epilepticus. Proteomics. 2007 Apr;7(8):1336-44. PubMed PMID: 17366478. 
2. Veyrac A. et al. Expression of collapsin response mediator proteins 1, 2 and 5 is differentially regulated in newly generated and mature neurons of the adult olfactory system. Eur J Neurosci. 2005;21:2635-48.
3. Bertin S. et al. Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain. J Comp Neurol. 2005;486:1-17.
4. Quach T. et al. Involvement of collapsin response mediator proteins in the neurite extension induced by neurotrophins in dorsal root ganglion neurons. Mol Cell Neurosci. 2004;25:433-43.
5. Charrier E. et al. Collapsin response mediator proteins (CRMPs): involvement in nervous system
development and adult neurodegenerative disorders. Mol Neurobiol. 2003;28:51-64. Review.
6. Ricard D et al. Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin
response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes. J Neurosci. 2001 ; 21:7203-14.
7. Honnorat J. et al. Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes. Eur J Neurosci. 1999;11:4226-32.

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