DPYSL4 / CRMP3 antibody

Principal name

DPYSL4 / CRMP3 antibody

Alternative names for DPYSL4 / CRMP3 antibody

DRP-4, UNC33-like phosphoprotein 4, ULIP4, Dihydropyrimidinase-related protein 4, Collapsin response mediator protein 3

SwissProt ID

O14531 (Human), O35098 (Mouse), Q62951 (Rat)

Gene ID

10570 (DPYSL4), 25417 (Dpysl4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Frozen Sections (C), Paraffin Sections (P)

Background of DPYSL4 / CRMP3 antibody

Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule Semaphorin 3A (SEMA3A)/collapsin. CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to Semaphorin 3A. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity. CRMP-3 is expressed transiently in developing spinal cord and selectively in the postnatal cerebellum. It is cleaved by Calpain to produce a p54 N-terminal fragment. This cleavage product translocates to the nucleus and induces neuronal death in response to excitotoxicity and cerebral ischemia.

General readings

1. Veyrac A. et al. Expression of collapsin response mediator proteins 1, 2 and 5 is differentially regulated in newly generated and mature neurons of the adult olfactory system. Eur J Neurosci. 2005;21:2635-48. 
2. Bertin S. et al. Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain. J Comp Neurol. 2005;486:1-17.
3. Quach T. et al. Involvement of collapsin response mediator proteins in the neurite extension induced by neurotrophins in dorsal root ganglion neurons. Mol Cell Neurosci. 2004;25:433-43.
4. Charrier E. et al. Collapsin response mediator proteins (CRMPs):
involvement in nervous system development and adult neurodegenerative disorders. Mol Neurobiol. 2003;28:51-64.
5. Ricard D. et al. Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes. J Neurosci. 2001 ; 21:7203-14.
6. Honnorat J. et al. Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes. Eur J Neurosci. 1999;11:4226-32.

16 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DPYSL4 / CRMP3 antibody

  Anti-DPYSL4 Rabbit Polyclonal Antibody  
Predicted band size: 62 kDa . Positive control: Human fetal brain tissue lysate. Recommended dilution: 1/500-1000. (Gel: 8%SDS-PAGE Lysate: 30 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 20 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DPYSL4 / CRMP3 antibody

  Anti-DPYSL4 Rabbit Polyclonal Antibody  
Predicted band size: 62kDa. Positive control: Huamn fetal brain tissue lysate . Recommended dilution: 1/500-2000 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DPYSL4 / CRMP3 antibody

Western blot (WB) analysis of CRMP-3 antibody (Cat.-No.: AP21162PU-N) in extracts from HT-29 cells. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

DPYSL4 / CRMP3 antibody

Immunoblot analysis of the specificity of polyclonal antibody to CRMP3 using E.coli transformed with cDNA of human CRMP3. Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

DPYSL4 / CRMP3 antibody

Western blot analysis of extracts from LOVO/HT-29 cells, using DPYSL4 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

DPYSL4 / CRMP3 antibody

Western blot analysis of extracts from LOVO/HT-29 cells, using DPYSL4 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

DPYSL4 - human gene knockout kit via CRISPR

DPYSL4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

DPYSL4 - human gene knockout kit via CRISPR

DPYSL4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

DPYSL4 - human gene knockout kit via CRISPR

DPYSL4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

DPYSL4 - human gene knockout kit via CRISPR

DPYSL4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

DPYSL4 / CRMP3

  Recombinant protein of human dihydropyrimidinase-like 4 (DPYSL4)  
DPYSL4 / CRMP3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

DPYSL4 overexpression lysate

DPYSL4 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, DPYSL4 (mGFP-tagged) - Human dihydropyrimidinase-like 4 (DPYSL4), 200 uL, >10^7 TU/mL

Lenti ORF particles, DPYSL4 (mGFP-tagged) - Human dihydropyrimidinase-like 4 (DPYSL4), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, DPYSL4 (Myc-DDK tagged) - Human dihydropyrimidinase-like 4 (DPYSL4) , 200 uL, >10^7 TU/mL

Lenti ORF particles, DPYSL4 (Myc-DDK tagged) - Human dihydropyrimidinase-like 4 (DPYSL4) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Dpysl4 (GFP-tagged ORF) - Rat dihydropyrimidinase-like 4 (Dpysl4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Dpysl4 (GFP-tagged ORF) - Rat dihydropyrimidinase-like 4 (Dpysl4), 200 uL, >10^7 TU/mL  
200 µl / €1,210.00
  OriGene Technologies, Inc.

Lenti ORF particles, Dpysl4 (Myc-DDK-tagged ORF) - Rat dihydropyrimidinase-like 4 (Dpysl4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Dpysl4 (Myc-DDK-tagged ORF) - Rat dihydropyrimidinase-like 4 (Dpysl4), 200 uL, >10^7 TU/mL  
200 µl / €1,088.00
  OriGene Technologies, Inc.

16 Item(s)

per page
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