Drebrin antibody

Principal name

Drebrin antibody

Alternative names for Drebrin antibody

DBN1, DBN-1, D0S117E, DKFZp434D064,drebrin 1, Developmentally-regulated brain protein

SwissProt ID

P18302 (Chick), Q07266 (Rat), Q16643 (Human), Q9QXS6 (Mouse)

Gene ID

1627 (DBN1), 6516274 (acpP), 396496

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Fe (Feline), GP (Guinea Pig), Por (Porcine), Chk (Chicken), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Guinea Pig

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Flow Cytometry (F)

Background of Drebrin antibody

Drebrin has been recently identified as a member of the newly identified ADF-H family of actin-binding proteins that share the structurally conserved actin-depolymerizing factor (ADF) binding module. Structurally related proteins, homologous to drebrin include Abp1/SH3P7 and HIP55/Drebrin F. Drebrin is composed of a single ADF-H domain at its N-terminus, followed by a non-conserved central region and a C-terminal SH3 domain. Drebrin is probably involved in actin remodeling. It colocalizes with actin filaments and dendritic-like cell processes. In drebrin-overexpressing fibroblasts, drebrin binds to F-actin with high affinity, it binds to and dissociates F-actin stabilizing proteins such as alpha-actinin, fascin, and tropomyosin from actin filaments.

Drebrin is thought to play a central role in the formation of axons and dendrites during neuronal development and in neuronal plasticity in the adult brain. The expression of each drebrin isoform is regulated throughout distinct phases in neuronal development. The earliest embryonic form E1, is thought to function in migration, while the E2 isoform, which replaces E1 during embryogenesis, is believed to play a role in migration as well as formation of axons and dendrites. Drebrin E2 is present at low levels in the adult brain. The drebrin A isoform, which is only present in mature neurons, is assumed to be involved in synaptic plasticity. Drebrin E2 and A isoforms are targeted to different regions of actin localization. In neurons, the E2 isoform localizes to the submembrane region, while the A isoform is specifically located and evenly distributed throughout the post-synaptic dendritic spine.

10 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Drebrin (C-term) antibody

Drebrin Mouse IgG1 MX823 Supernatant Bov, Can, Hu, Ms, Rt C, ICC/IF, IP, WB
5 ml / €290.00
  Acris Antibodies GmbH

Drebrin (1-326) antibody

Western blotting analysis of Drebrin expression in REH, Ramos, and Nalm-6 cell lysate using Mouse Monoclonal Antibody Cat.-No AM32471PU-N  (Clone DBN-N-03). Mouse IgG2b DBN-N-03 Purified Hu F, WB
0.1 mg / €260.00
  Acris Antibodies GmbH

Drebrin (1-326) antibody

Surface staining (mass cytometry) of brain tumor cells with anti-drebrin (DBN-N-03) 152Sm. Gated on singlets. Mouse IgG2b DBN-N-03 PE Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

Drebrin (C-term) antibody

Drebrin Mouse IgG1 MX823 Ascites Bov, Can, Hu, Ms, Rt C, ICC/IF, IP, WB
0.25 ml / €330.00
  Acris Antibodies GmbH

Drebrin (324-343) antibody

Drebrin Guinea Pig Serum Bov, Hu, Ms, Rt C, ICC/IF, IP, P, WB
0.1 ml / €370.00
  Acris Antibodies GmbH

Drebrin (254-272) antibody

Drebrin Guinea Pig Serum Bov, Hu, Ms, Rt C, ICC/IF, IP, P, WB
0.1 ml / €370.00
  Acris Antibodies GmbH

Drebrin antibody

Detection limit for recombinant GST tagged DBN1 is approximately 0.1ng/ml as a capture antibody. Mouse IgG2a 2E11 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Drebrin antibody

Western Blot: Drebrin Antibody (M2F6) [NB100-1951] - Western blot analysis of mouse brain tissue extract probed with NB100-1951 Mouse IgG M2F6 Purified Bov, Chk, Fe, Hu, Ms, Rb, Rt P, WB
50 µg / €360.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Drebrin

Drebrin Human in vitro transl.
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

DBN1 overexpression lysate

DBN1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

10 Item(s)

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