DTX3L / BBAP antibody
Principal name
DTX3L / BBAP antibody
Alternative names for DTX3L / BBAP antibody
Protein deltex-3-like, Rhysin-2, B-lymphoma- and BAL-associated protein
SwissProt ID
Q8TDB6 (Human)
Gene ID
151636 (DTX3L)
Ncbi ID
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP)
Background of DTX3L / BBAP antibody
Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
General readings
Yan, Q., et al. Mol. Cell 36(1):110-120(2009).
Wilting, S.M., et al. Genes Chromosomes Cancer 47(10):890-905 (2008).
Juszczynski, P., et al. Mol. Cell. Biol. 26(14):5348-5359 (2006).
Takeyama, K., et al. J. Biol. Chem. 278(24):21930-21937 (2003).









Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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AP51334PU-N | DTX3L / BBAP (Center) antibody |
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Rabbit | Ig | Aff - Purified | Hu | WB |
0.4 ml /
€370.00
|
|
Acris Antibodies GmbH |
CRISPR
Catalog No. | Species | Donor Vector | |
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KN207944 | DTX3L - human gene knockout kit via CRISPR |
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Human | GFP-Puro |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN207944BN | DTX3L - human gene knockout kit via CRISPR |
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Human | mBFP-Neo |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN207944LP | DTX3L - human gene knockout kit via CRISPR |
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Human | Luciferase-Puro |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN207944RB | DTX3L - human gene knockout kit via CRISPR |
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Human | RFP-BSD |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. |
Proteins & Growth Factors
Catalog No. | Species | Pres. | Purity | Source | |
---|---|---|---|---|---|
TP307944 | DTX3L / BBAP |
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Recombinant protein of human deltex 3-like (Drosophila) (DTX3L) | |||||
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Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€680.00
|
|
OriGene Technologies, Inc. |
Human Lenti ORF Particles
Catalog No. | ||
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RC207944L2V | Lenti ORF particles, DTX3L (mGFP-tagged) - Human deltex 3-like (Drosophila) (DTX3L), 200 uL, >10^7 TU/mL |
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200 µl /
€1,669.00
|
|
OriGene Technologies, Inc. | ||
RC207944L1V | Lenti ORF particles, DTX3L (Myc-DDK tagged) - Human deltex 3-like (Drosophila) (DTX3L) , 200 uL, >10^7 TU/mL |
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200 µl /
€1,504.00
|
|
OriGene Technologies, Inc. | ||