DUSP11 antibody

Principal name

DUSP11 antibody

Alternative names for DUSP11 antibody

PIR1, RNA/RNP complex-1-interacting phosphatase, Phosphatase that interacts with RNA/RNP complex 1, Dual specificity protein phosphatase 11

SwissProt ID

O75319 (Human), Q5E999 (Bovin), Q6NXK5 (Mouse)

Gene ID

72102 (Dusp11), 8446 (DUSP11)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Eq (Equine), Por (Porcine), Rb (Rabbit), Rt (Rat), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of DUSP11 antibody

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism.

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