DUSP3 antibody

Principal name

DUSP3 antibody

Alternative names for DUSP3 antibody

VHR, Dual specificity protein phosphatase 3, Dual specificity protein phosphatase VHR, Vaccinia H1-related phosphatase

SwissProt ID

P51452 (Human), Q9D7X3 (Mouse)

Gene ID

1845 (DUSP3), 72349 (Dusp3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP)

Background of DUSP3 antibody

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases ictivate their target kises by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kise superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kises, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq]

General readings

Alonso, A., Rahmouni, S., Williams, S., van Stipdonk, M., Jaroszewski, L., Godzik, A., Abraham, R.
T., Schoenberger, S. P., Mustelin, T. Tyrosine phosphorylation of VHR phosphatase by
ZAP-70. Nature Immun. 4: 44-48, 2003.
2. Ishibashi, T., Bottaro, D. P., Chan, A., Miki, T., Aaronson, S. A. Expression cloning of a human
dual-specificity phosphatase. Proc. Nat. Acad. Sci. 89: 12170-12174, 1992.
3. Patterson, K. I., Brummer, T., O'Brien, P. M., Daly, R. J. Dual-specificity phosphatases: critical
regulators with diverse cellular targets.Biochem. J. 418: 475-489, 2009.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DUSP3 (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  OriGene Technologies GmbH

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