DUSP6 antibody

Principal name

DUSP6 antibody

Alternative names for DUSP6 antibody

MKP3, PYST1, Dual specificity protein phosphatase 6, Mitogen-activated protein kinase phosphatase 3, Dual specificity protein phosphatase PYST1

SwissProt ID

Q16828 (Human), Q2KJ36 (Bovin), Q64346 (Rat), Q9DBB1 (Mouse)

Gene ID

1848 (DUSP6)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Mky (Monkey)

Available hosts

Mouse, Rabbit, Chicken, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Flow Cytometry (F), Immunoprecipitation (IP)

Background of DUSP6 antibody

MKP-3 is expressed constitutively in human skin fibroblasts and dephosphorylates and inactivates MAP kinase in vitro and in vivo. MKP-3 displays very low activity towards the stress-activated protein kinases (SAPKs) or RK/p38 in vitro, indicating that these kinases are not physiological substrates for MKP-3. MKP-3 is thought to play a role in the dephosphorylation and inactivation of MAP kinases and are therefore likely to be important in the regulation of diverse cellular processes such as proliferation, differentiation, and apoptosis. For this reason it has been suggested that MAP kinase phosphatases may be tumor suppressors (1). MKP-3 is expressed in lung, heart, brain, and kidney, but not significantly in skeletal muscle or testis. In situ hybridization studies of MKP-3 in brain reveal enrichment within the CA1, CA3, and CA4 layers of the hippocampus. Observations indicate that MKP-3 is a novel dual-specificity phosphatase that displays a distinct tissue distribution, subcellular localization, and regulated expression, suggesting a unique function in controlling MAP kinase family members (2).

General readings

General / background references:Groom LA et al. Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. EMBO J 15:3621-32 (1996). PubMed PMID: 8670865

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DUSP6 antibody

Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 3G2 Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

DUSP6 antibody

Immunoperoxidase of monoclonal antibody to DUSP6 on formalin-fixed paraffin-embedded human pancreas. [antibody concentration 3 ug/ml] Mouse IgG1 3G2 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

DUSP6 antibody

Sample (30 ug of whole cell lysate). A: A549. 10% SDS PAGE. TA308575 diluted at 1:1000. Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DUSP6 antibody

DUSP6 antibody [N2C3] detects DUSP6 protein by western blot analysis. A. 50 ug rat liver extract. 10 % SDS-PAGE. DUSP6 antibody [N2C3] (TA308656) dilution: 1:1000 Rabbit IgG Aff - Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DUSP6 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using DUSP6 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

DUSP6 antibody

Western blot analysis of Jurkat cell and human fetal kidney tissue using TA323083(DUSP6 Antibody) at dilution 1/450 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DUSP6 antibody

Predicted cell location: Cytoplasm. Positive control: Human colon cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using DUSP6 antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

DUSP6 (C-term) antibody

TA348992 (0.3 ug/ml) staining of Human (A), (Mouse) and Rat (C) Heart lysates (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

DUSP6 antibody

The anti-DUSP6 Pab is used in Western blot to detect DUSP6 in HeLa cell lysate. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

DUSP6 antibody

DUSP6 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

DUSP6 antibody

DUSP6 MaxPab rabbit polyclonal antibody. Western Blot analysis of DUSP6 expression in human pancreas. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

DUSP6 antibody

DUSP6 Mouse IgG1 3G2 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

DUSP6 antibody

The DUSP6 polyclonal antibody ( Cat # PAB4131 ) is used in Western blot to detect DUSP6 in HeLa cell lysate. Rabbit Hu E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

DUSP6 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using DUSP6 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €205.00
  Assay Biotech

DUSP6 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using DUSP6 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €310.00
  Assay Biotech

DUSP6 antibody

Immunohistochemical analysis of DUSP6 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rt ICC/IF, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

DUSP6 antibody

Immunohistochemical analysis of DUSP6 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rt ICC/IF, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

DUSP6 antibody

Immunohistochemical analysis of DUSP6 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rt ICC/IF, P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

DUSP6 antibody

Western blot analysis of DUSP6 expression in HepG2 (A); NIH3T3 (B); rat heart (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

DUSP6 antibody

Western blot analysis of DUSP6 expression in HepG2 (A); NIH3T3 (B); rat heart (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

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