DUSP8 / VH5 antibody

Principal name

DUSP8 / VH5 antibody

Alternative names for DUSP8 / VH5 antibody

Dual specificity protein phosphatase 8

SwissProt ID

O09112 (Mouse), Q13202 (Human)

Gene ID

1850 (DUSP8), 18218 (Dusp8)

Available reactivities

Hu (Human), Bov (Bovine), Chk (Chicken), Ms (Mouse), Rt (Rat), Can (Canine), GP (Guinea Pig)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of DUSP8 / VH5 antibody

DUSP8 is a member of the dual specificity protein phosphatase subfamily. These phosphatases ictivate their target kises by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kise superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kises, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP8ictivates SAPK/JNK and p38, is expressed predomintly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin.The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases ictivate their target kises by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kise superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kises, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product ictivates SAPK/JNK and p38, is expressed predomintly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.

General readings

Martell KJ, Seasholtz AF, Kwak SP, Clemens KK, Dixon JE.
hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase.
J Neurochem. 1995 Oct;65(4):1823-33.
PMID: 7561881

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DUSP8 / VH5 (N-term) antibody

  Goat Polyclonal Antibody against DUSP8  
TA302764 staining (2µg/ml) of Human Heart lysate (RIPA buffer, 30µg total protein per lane).  Primary incubated for 12 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

DUSP8 / VH5 antibody

  Rabbit Polyclonal antibody to DUSP8 (dual specificity phosphatase 8)  
Sample(30 ug of whole cell lysate). A:Raji . 7.5% SDS PAGE. TA308797 diluted at 1:1000 Rabbit IgG Aff - Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DUSP8 / VH5 antibody

  Anti-DUSP8 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human lung cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using DUSP8 antibody at dilution 1/40, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

DUSP8 / VH5 antibody

  Anti-DUSP8 Rabbit Polyclonal Antibody  
Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane: 293T cells, Primary antibody: DUSP8 Antibody at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DUSP8 / VH5 antibody

  Rabbit Polyclonal Anti-DUSP8 Antibody  
WB Suggested Anti-DUSP8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 2500; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

DUSP8 / VH5 (250-300) antibody

Heart: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

DUSP8 / VH5 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

Dusp8 - mouse gene knockout kit via CRISPR

Dusp8 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dusp8 - mouse gene knockout kit via CRISPR

Dusp8 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

DUSP8 overexpression lysate

DUSP8 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, DUSP8 (mGFP-tagged) - Human dual specificity phosphatase 8 (DUSP8), 200 uL, >10^7 TU/mL

Lenti ORF particles, DUSP8 (mGFP-tagged) - Human dual specificity phosphatase 8 (DUSP8), 200 uL, >10^7 TU/mL  
200 µl / €1,280.00
  OriGene Technologies, Inc.

Lenti ORF particles, DUSP8 (Myc-DDK tagged) - Human dual specificity phosphatase 8 (DUSP8) , 200 uL, >10^7 TU/mL

Lenti ORF particles, DUSP8 (Myc-DDK tagged) - Human dual specificity phosphatase 8 (DUSP8) , 200 uL, >10^7 TU/mL  
200 µl / €1,150.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Dusp8 (GFP-tagged) - Mouse dual specificity phosphatase 8 (Dusp8), 200 uL, >10^7 TU/mL

Lenti ORF particles, Dusp8 (GFP-tagged) - Mouse dual specificity phosphatase 8 (Dusp8), 200 uL, >10^7 TU/mL  
200 µl / €1,340.00
  OriGene Technologies, Inc.

Lenti ORF particles, Dusp8 (Myc-DDK-tagged) - Mouse dual specificity phosphatase 8 (Dusp8), 200 uL, >10^7 TU/mL

Lenti ORF particles, Dusp8 (Myc-DDK-tagged) - Mouse dual specificity phosphatase 8 (Dusp8), 200 uL, >10^7 TU/mL  
200 µl / €1,200.00
  OriGene Technologies, Inc.

14 Item(s)

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