Dynactin subunit 1 antibody

Principal name

Dynactin subunit 1 antibody

Alternative names for Dynactin subunit 1 antibody

DCTN1, DAP-150, DP-150, p150-glued, p135, 150 kDa dynein-associated polypeptide

SwissProt ID

O08788 (Mouse), P28023 (Rat), P35458 (Chick), Q14203 (Human)

Gene ID

1639 (DCTN1), 29167 (Dctn1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Dros (Drosophila), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Mouse, Goat, Rabbit, Sheep

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of Dynactin subunit 1 antibody

Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.Tissue specificity; Brain.Involvement in disease; Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B); also known as progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.Defects in DCTN1 are the cause of Perry syndrome (PERRYS); also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally.

General readings

Holzbaur EL & Tokito MK Localization of the DCTN1 gene encoding p150Glued to human chromosome 2p13 by fluorescence in situ hybridization. Genomics 31:398-9 (1996). PubMed PMID: 8838327

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Dynactin subunit 1 (C-term) antibody

TA302830 staining (1µg/ml) of Human Testis lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Dynactin subunit 1 antibody

Sample (30 ug of whole cell lysate). A: JurKat. 5% SDS PAGE. TA307941 diluted at 1:3000. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Dynactin subunit 1 antibody

Western blot analysis of extracts of various cell lines, using DCTN1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Dynactin subunit 1 antibody

WB Suggested Anti-Dctn1 Antibody; Titration: 1.0 ug/ml; Positive Control: Rat Thymus Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Dynactin subunit 1 antibody

Dynactin subunit 1 Mouse IgG2b 3D5-C6-D5 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Dynactin subunit 1 antibody

Dynactin subunit 1 Mouse IgG1 1E12 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Dynactin subunit 1 antibody

Dynactin subunit 1 Mouse IgG1 2E4-1C2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Dynactin subunit 1 antibody

DCTN1 polyclonal antibody ( Cat # PAB6249 ) ( 2.5µg/ml ) staining staining of paraffin embedded human cerebellum. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Hu, Ms E, P, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Dynactin subunit 1 (C-term) antibody

DCTN1 staining  (dilution: 2.5µg/ml) staining of human brain tissue, cortex (formalin-fixed paraffin-embedded) followed by biotinylated horse anti-goat IgG secondary antibody,  alkaline phosphatase-streptavidin and chromogen. Protocol on data-sheet. Goat IgG Aff - Purified Hu, Ms P, WB
0.1 mg / €400.00
  Neuromics Antibodies

Dynactin subunit 1 antibody

Immunohistochemistry: DCTN1 Antibody [NB100-1110] - (2.5µg/ml) staining of paraffin embedded Human Cerebellum. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Dynactin subunit 1 antibody

Dynactin subunit 1 Rabbit Serum Dros P, WB
0.2 ml / €400.00
  Novus Biologicals Inc.

Dynactin subunit 1 antibody

Dynactin subunit 1 Sheep IgG Hu, Ms, Rt P, WB
0.5 mg / €400.00
  Novus Biologicals Inc.

Dynactin subunit 1 antibody

Western Blot: DCTN1 Antibody [NBP1-30880] - Whole cell lysate treated with DCTN1 Antibody, diluted at 1:1000 with 7.5% SDS PAGE gel. Rabbit IgG Hu ICC/IF, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

Dynactin subunit 1 antibody

Western Blot: DCTN1 Antibody [NBP1-71829]-Whole cell lysate from Jurkat (5, 15 and 50 mcg for WB), HeLa (H, 50 mcg; 1 mg for IP, 20% of IP loaded) and mouse NIH3T3 (M; 50 mcg) cells.  Affinity purified rabbit anti-p150glued antibody used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 6 mcg/mg lysate.  p150glued was also immunoprecipitated by rabbit anti-p150glued antibody NBP1-71828, which recognizes an upstream epitope. Rabbit Aff - Purified Hu, Ms IP, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Dynactin subunit 1

Dynactin subunit 1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Dynactin subunit 1

Dynactin subunit 1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

DCTN1 overexpression lysate

DCTN1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

17 Item(s)

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