Dynamin-1-like protein antibody

Principal name

Dynamin-1-like protein antibody

Alternative names for Dynamin-1-like protein antibody

DNM1L, DLP1, DRP1, Dynamin-like protein, Dnm1p/Vps1p-like protein, HdynIV, Dynamin family member proline-rich carboxyl-terminal domain less, Dynamin-related protein 1, Dynamin-like protein 4, Dynamin-like protein IV

SwissProt ID

O00429 (Human), O35303 (Rat), Q2KIA5 (Bovin), Q792T7 (Rat), Q7SXN5 (Danre), Q8K1M6 (Mouse)

Gene ID

10059 (DNM1L), 74006 (Dnm1l), 114114

Available reactivities

Dros (Drosophila), Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Mky (Monkey), Hst (Hamster), Prim (Primate)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Dynamin-1-like protein antibody

Mitochondria are dynamic organelles that frequently move, divide, and fuse with one another to maintain their architecture and functions. Changes in mitochondrial morphology is tightly coupled with cell cycle, differentiation and death, these physiological phenomenon are regulated by the balance between mitochondrial fusion and fission process. Any disruption in dynamic equilibrium between fusion and fission due to cell injury or death may contribute to developmental and neurodegenerative disorders. Inhibition of fusion caused machinery can caused excessive fragmentation that led to dysfunctional organelle. Calcineurin dependent translocation of a pro-fission protein dynamin related protein 1 (Drp1) to mitochondria was observed in dysfunction-induced fragmentation. Drp1 interacts with cytosolic phosphatase calcineurin during mitochondrial depolarization due to sustained cytosolic Ca increase. The translocation of Drp1 is dependent upon calcineurin-dependent dephosphorylation of serine 637 of Drp1 (1). In neurons and in HeLa cells the CaMKI alfa-dependent phosphorylation of Ser600 by of Drp1 resulted in increased trans location of Drp1 in to mitochondria (2).
Fragmentation of mitochondria triggered by dysfunction of the Drp1 protein led to synaptic damage and subsequent neuronal loss and impaired bioenergetics. Excessive fragmentation results in abnormally small mitochondria with broken cristae as observed in electron microscopy of neurons from studies of Alzheimer’s disease (3). Recent studies have suggested that Drp1 undergo S-Nitrosylation which regulate its activity to induce mitochondrial fission and neuronal damage in a NO mediated fashion (4). It is suggested that NO produced in response to beta-amyloid protein play a key role in mitochondrial fission, synaptic loss and neuronal damage in Alzheimer disease via S-notrosylation of Drp1 forming SNO-Drp1 (4). Increased concentration of SNO-Drp1 is found in Alzheimer’s brain which may contribute to the pathogenesis of neuro-degeneration. Preventing nitrosolyation of Drp1 abrogates the neurotoxic events. Drp1 (736 aa) is a highly conserved protein among humans, rat, mouse and fly genome. The protein has a amino terminal Ras-like GTPase superfamily domain, a Dynamin-M domain and a GED domain.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Dynamin-1-like protein antibody

  DNM1L mouse monoclonal antibody, clone OTI2E7 (formerly 2E7)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-DNM1L mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506115) Mouse IgG2b OTI2E7 Purified Hu, Mky, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Dynamin-1-like protein antibody

  DNM1L mouse monoclonal antibody, clone OTI4F6 (formerly 4F6)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-DNM1L mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506153) Mouse IgG2b OTI4F6 Purified Can, Hu, Mky, Ms, Rt P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Dynamin-1-like protein antibody

  Rabbit Polyclonal DNM1L Antibody  
Western blot analysis of DNM1L in HeLa cell lysate with DNM1L antibody at 1 ug/ml. Rabbit IgG Purified Hu, Ms ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Dynamin-1-like protein antibody

  DRP1 Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using DRP1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Dynamin-1-like protein antibody

  Mouse Monoclonal DRP1 Antibody (4E11B11)  
Western Blot: DRP1 Antibody (4E11B11) [TA336948] - Western blot analysis using DRP1 mAb in (1) HEK293 and (2) DRP1 hIgGFc transfected HEK293 cell lysate. Mouse IgG1 4E11B11 Purified Hu C, E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Dynamin-1-like protein antibody

  DNM1L mouse monoclonal antibody, clone OTI3F4 (formerly 3F4)  
Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-DNM1L mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506112) Mouse IgG2b OTI3F4 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Dynamin-1-like protein antibody

  DNM1L mouse monoclonal antibody, clone OTI3F3 (formerly 3F3)  
Immunohistochemical staining of paraffin-embedded Human bladder tissue within the normal limits using anti-DNM1L mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506114) Mouse IgG2b OTI3F3 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Dynamin-1-like protein antibody

  DNM1L mouse monoclonal antibody, clone OTI1C1 (formerly 1C1)  
Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-DNM1L mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506116) Mouse IgG2b OTI1C1 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Dynamin-1-like protein antibody

  DNM1L mouse monoclonal antibody, clone OTI4B5 (formerly 4B5)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-DNM1L mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506151) Mouse IgG2b OTI4B5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Dynamin-1-like protein antibody

  DNM1L mouse monoclonal antibody, clone OTI4A4 (formerly 4A4)  
Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-DNM1L mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506198) Mouse IgG2b OTI4A4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Dynamin-1-like protein antibody

  Rabbit Polyclonal Antibody against DRP1  
Western Blot: DRP1 Antibody TA301510 - Staining of DRP-1 in mouse embryonic fibroblast post-nuclear extracts. Image courtesy of D. Chan California Institute of Technology. Rabbit IgG Purified Hst, Hu, Ms, Prim WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Dynamin-1-like protein antibody

  Rabbit Polyclonal Antibody against DRP1  
Lane 1: DRP1 knockout, Lane 2: DRP1 wildtype MEFs at 1:500x dilution Rabbit IgG Purified Hst, Hu, Ms, Prim, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Dynamin-1-like protein antibody

  Rabbit polyclonal DRP1 (Ab-637) antibody  
Western blot analysis of extracts from CoLo,HepG2,JK cells, using DRP1 (Ab-637)antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Dynamin-1-like protein antibody

  Rabbit polyclonal DRP1 (Ser637) antibody(Phospho-specific)  
Dynamin-1-like protein Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Dynamin-1-like protein pSer637 antibody

Western blot analysis of extracts from JK cells and K562 cells using DRP1 (Phospho-Ser637) Antibody AP55855PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €340.00
  Acris Antibodies GmbH

Dynamin-1-like protein pSer637 antibody

Western blot analysis of extracts from JK cells and K562 cells using DRP1 (Phospho-Ser637) Antibody AP55855PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / €270.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

DNM1L - human gene knockout kit via CRISPR

DNM1L - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

DNM1L - human gene knockout kit via CRISPR

DNM1L - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

DNM1L - human gene knockout kit via CRISPR

DNM1L - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dnm1l - mouse gene knockout kit via CRISPR

Dnm1l - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

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