DYRK1A antibody

Principal name

DYRK1A antibody

Alternative names for DYRK1A antibody

DYRK, MNB, MNBH, Protein kinase minibrain homolog, HP86, Dual specificity YAK1-related kinase, Dual specificity tyrosine-phosphorylation-regulated kinase 1A

SwissProt ID

P85051 (Rabit), Q13627 (Human), Q2TAE3 (Xenla), Q61214 (Mouse), Q63470 (Rat)

Gene ID

1859 (DYRK1A), 13548 (Dyrk1a), 25255

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Rb (Rabbit), Bov (Bovine), Can (Canine), Por (Porcine), Eq (Equine), GP (Guinea Pig), Ze (Zebrafish)

Available hosts

Mouse, Rabbit, Sheep, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Frozen Sections (C)

Background of DYRK1A antibody

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kise (DYRK) family. This member contains a nuclear targeting sigl sequence, a protein kise domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a sigling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Altertive splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008].

General readings

1. Baek KH  et al. Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature 459:1126-30 (2009). WB ; Human .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DYRK1A antibody

Western blot analysis of Dyrk1A antibody (Cat.-No.: AP06728PU-N) in extracts from HepG2 cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  OriGene Technologies GmbH

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