Dysadherin / FXYD5 antibody

Principal name

Dysadherin / FXYD5 antibody

Alternative names for Dysadherin / FXYD5 antibody

DYSAD, IWU1, FXYD domain-containing ion transport regulator 5

SwissProt ID

P59647 (Rat), P97808 (Mouse), Q96DB9 (Human)

Gene ID

53827 (FXYD5), 18301 (Fxyd5)

Available reactivities

Hu (Human), Ms (Mouse), Ye (Yeast)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of Dysadherin / FXYD5 antibody

FXYD5 is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, has not been characterized as a protein.This reference sequence was derived from AF161462.1 and ESTs; validated by multiple replicate ESTs and human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, has not been characterized as a protein. Two transcript variants have been found for this gene, and they are both predicted to encode the same protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu.].

General readings

1. Ino, Y., Gotoh, M., Sakamoto, M., Tsukagoshi, K., Hirohashi, S. Dysadherin, a cancer-associated
cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis. Proc. Nat. Acad.
Sci. 99: 365-370, 2002.
2. Omasa, T., Chen, Y.-G., Mantalaris, A., Wu, J. H. D. A cDNA from human bone marrow encoding a
protein exhibiting homology to the ATP1-gamma-1/PLM/MAT8 family of transmembrane
proteins. Biochim. Biophys. Acta 1517: 307-310, 2001.
3. Sweadner, K. J., Rael, E. The FXYD gene family of small ion transport regulators or channels:
cDNA sequence, protein signature sequence, and expression. Genomics 68: 41-56, 2000

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Dysadherin / FXYD5 (C-term) antibody

  Goat Polyclonal Antibody against FXYD5  
TA302772 staining (0.5µg/ml) of Jurkat lysate (RIPA buffer, 30µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Dysadherin / FXYD5 antibody

  Rabbit polyclonal Anti-FXYD5 Antibody  
WB Suggested Anti-FXYD5 Antibody Titration: 0.625ug/ml; ELISA Titer: 1:312500; Positive Control: Human Placenta Rabbit IgG Purified Hu, Ms, Ye WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Dysadherin / FXYD5 antibody

  Rabbit Polyclonal Anti-FXYD5 Antibody  
WB Suggested Anti-FXYD5 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Human heart Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Dysadherin / FXYD5 antibody

  Rabbit Polyclonal Anti-FXYD5 Antibody  
WB Suggested Anti-FXYD5 Antibody Titration: 1.25 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Dysadherin / FXYD5 (Center) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human rectum tissue reacted with Dysadherin / FXYD5 Antibody (Center) Cat.-No AP51745PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

FXYD5 - human gene knockout kit via CRISPR

FXYD5 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

FXYD5 - human gene knockout kit via CRISPR

FXYD5 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

FXYD5 - human gene knockout kit via CRISPR

FXYD5 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

FXYD5 - human gene knockout kit via CRISPR

FXYD5 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Fxyd5 - mouse gene knockout kit via CRISPR

Fxyd5 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Fxyd5 - mouse gene knockout kit via CRISPR

Fxyd5 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Fxyd5 - mouse gene knockout kit via CRISPR

Fxyd5 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Fxyd5 - mouse gene knockout kit via CRISPR

Fxyd5 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Dysadherin / FXYD5 (22-145, His-tag)

Dysadherin / FXYD5 Human Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

Dysadherin / FXYD5 (22-145, His-tag)

Dysadherin / FXYD5 Human Purified > 95 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

FXYD5 overexpression lysate

FXYD5 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

FXYD5 overexpression lysate

FXYD5 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

FXYD5 overexpression lysate

FXYD5 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

FXYD5 overexpression lysate

FXYD5 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, FXYD5 (mGFP-tagged)-Human FXYD domain containing ion transport regulator 5 (FXYD5), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, FXYD5 (mGFP-tagged)-Human FXYD domain containing ion transport regulator 5 (FXYD5), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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