Dysbindin antibody

Principal name

Dysbindin antibody

Alternative names for Dysbindin antibody

Dystrobrevin-binding protein 1, DTNBP1, My031, Hps7-like protein, Hermansky-Pudlak syndrome 7 protein homolog

SwissProt ID

Q2HJA5 (Bovin), Q5M834 (Rat), Q5ZKM0 (Chick), Q91WZ8 (Mouse), Q96EV8 (Human)

Gene ID

94245 (Dtnbp1), 84062 (DTNBP1), 641528

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of Dysbindin antibody

Dysbindin, or dystrobrevin-binding protein 1, is a coiled-coil-containing protein expressed in muscle and brain that was identified as a binding partner of dystrobrevin. Dysbindin upregulates expression of the pre-syptic proteins SP25 and sypsin I, thereby increasing glutamate release and promoting neurol viability through Akt sigling. In particular, Akt phosphorylation is suppressed with downregulation of dysbindin and increased with upregulation of dysbindin. A nonsense mutation of dysbindin causes Hermansky-Pudlak disease, an autosomal recessive disorder characterized by lysosomal storage defects and prolonged bleeding. Genetic variation in the gene encoding dysbindin is strongly associated with schizophrenia and protein levels are reduced in the prefrontal cortex, midbrain and hippocampus of brains from patients with schizophrenia.

General readings

Haukvik, U.K., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 34(7):1259-1265(2010).
Voisey, J., et al. Eur. Psychiatry 25(6):314-319 (2010).
Ruano, G., et al. Pharmacogenomics 11(7):959-971 (2010).
Hashimoto, R., et al. Nihon Shinkei Seishin Yakurigaku Zasshi 30(3):103-107 (2010).
Voisey, J., et al. Behav Brain Funct 6, 41 (2010).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Dysbindin antibody

  DTNBP1 Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using DTNBP1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Dysbindin (C-term) antibody

  Rabbit Polyclonal Antibody against DTNBP1  
Western blot analysis of Dtnbp1(arrow) using rabbit polyclonal Dysbindin(Dtnbp1)  Antibody (C-term) (Cat.#TA300078). Rabbit Ig Aff - Purified Hu, Ms P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Dysbindin antibody

  Anti-DTNBP1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human brain and thyroid cancer tissue. Recommended dilution: 1/20-100  The image on the left is immunohistochemistry of paraffin-embedded Human brain and thyroid cancer tissue using DTNBP1 antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Dysbindin antibody

  Rabbit Polyclonal Anti-DTNBP1 Antibody  
Host: Rabbit; Target Name: DTNBP1; Sample Tissue: HepG2 Whole Cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Dysbindin (N-term) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with Dtnbp1 Antibody (N-term) (Cat.#AP12328PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Dysbindin (N-term) antibody

Western blot analysis of DTNBP1 (arrow) using Dysbindin Antibody (N-term) Cat.-No AP51331PU-N. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the DTNBP1 gene. Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

DTNBP1 - human gene knockout kit via CRISPR

DTNBP1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

DTNBP1 - human gene knockout kit via CRISPR

DTNBP1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dtnbp1 - mouse gene knockout kit via CRISPR

Dtnbp1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Dtnbp1 - mouse gene knockout kit via CRISPR

Dtnbp1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dtnbp1 - mouse gene knockout kit via CRISPR

Dtnbp1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dtnbp1 - mouse gene knockout kit via CRISPR

Dtnbp1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Dysbindin (transcript variant 1)

  Recombinant protein of human dystrobrevin binding protein 1 (DTNBP1), transcript variant 1  
Dysbindin Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Dysbindin (1-270, His-tag)

Dysbindin Human Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €1,000.00
  Acris Antibodies GmbH

Dysbindin (1-270, His-tag)

Dysbindin Human Purified > 95 % by SDS - PAGE E. coli
0.1 mg / €370.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

DTNBP1 overexpression lysate

DTNBP1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

DTNBP1 overexpression lysate

DTNBP1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

DTNBP1 overexpression lysate

DTNBP1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, DTNBP1 (mGFP-tagged) - Human dystrobrevin binding protein 1 (DTNBP1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, DTNBP1 (mGFP-tagged) - Human dystrobrevin binding protein 1 (DTNBP1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, DTNBP1 (Myc-DDK tagged) - Human dystrobrevin binding protein 1 (DTNBP1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, DTNBP1 (Myc-DDK tagged) - Human dystrobrevin binding protein 1 (DTNBP1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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