Dysbindin antibody

Principal name

Dysbindin antibody

Alternative names for Dysbindin antibody

Dystrobrevin-binding protein 1, DTNBP1, My031, Hps7-like protein, Hermansky-Pudlak syndrome 7 protein homolog

SwissProt ID

Q2HJA5 (Bovin), Q5M834 (Rat), Q5ZKM0 (Chick), Q91WZ8 (Mouse), Q96EV8 (Human)

Gene ID

94245 (Dtnbp1), 84062 (DTNBP1), 641528

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of Dysbindin antibody

Dysbindin, or dystrobrevin-binding protein 1, is a coiled-coil-containing protein expressed in muscle and brain that was identified as a binding partner of dystrobrevin. Dysbindin upregulates expression of the pre-syptic proteins SP25 and sypsin I, thereby increasing glutamate release and promoting neurol viability through Akt sigling. In particular, Akt phosphorylation is suppressed with downregulation of dysbindin and increased with upregulation of dysbindin. A nonsense mutation of dysbindin causes Hermansky-Pudlak disease, an autosomal recessive disorder characterized by lysosomal storage defects and prolonged bleeding. Genetic variation in the gene encoding dysbindin is strongly associated with schizophrenia and protein levels are reduced in the prefrontal cortex, midbrain and hippocampus of brains from patients with schizophrenia.

General readings

Haukvik, U.K., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 34(7):1259-1265(2010).
Voisey, J., et al. Eur. Psychiatry 25(6):314-319 (2010).
Ruano, G., et al. Pharmacogenomics 11(7):959-971 (2010).
Hashimoto, R., et al. Nihon Shinkei Seishin Yakurigaku Zasshi 30(3):103-107 (2010).
Voisey, J., et al. Behav Brain Funct 6, 41 (2010).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Dysbindin antibody

  DTNBP1 Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using DTNBP1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €335.00
  OriGene Technologies, Inc.

Dysbindin antibody

  Anti-DTNBP1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human brain and thyroid cancer tissue. Recommended dilution: 1/20-100  The image on the left is immunohistochemistry of paraffin-embedded Human brain and thyroid cancer tissue using DTNBP1 antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €335.00
  OriGene Technologies, Inc.

Dysbindin antibody

  Rabbit Polyclonal Anti-DTNBP1 Antibody  
Host: Rabbit; Target Name: DTNBP1; Sample Tissue: HepG2 Whole Cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Hu WB
50 µg / €360.00
  OriGene Technologies, Inc.

Dysbindin (N-term) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with Dtnbp1 Antibody (N-term) (Cat.#AP12328PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Dysbindin (1-270, His-tag)

Dysbindin Human Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €1,000.00
  Acris Antibodies GmbH

Dysbindin (1-270, His-tag)

Dysbindin Human Purified > 95 % by SDS - PAGE E. coli
0.1 mg / €370.00
  Acris Antibodies GmbH

6 Item(s)

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