Dysbindin antibody

Principal name

Dysbindin antibody

Alternative names for Dysbindin antibody

Dystrobrevin-binding protein 1, DTNBP1, My031, Hps7-like protein, Hermansky-Pudlak syndrome 7 protein homolog

SwissProt ID

Q2HJA5 (Bovin), Q5M834 (Rat), Q5ZKM0 (Chick), Q91WZ8 (Mouse), Q96EV8 (Human)

Gene ID

94245 (Dtnbp1), 84062 (DTNBP1), 641528

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of Dysbindin antibody

Dysbindin, or dystrobrevin-binding protein 1, is a coiled-coil-containing protein expressed in muscle and brain that was identified as a binding partner of dystrobrevin. Dysbindin upregulates expression of the pre-syptic proteins SP25 and sypsin I, thereby increasing glutamate release and promoting neurol viability through Akt sigling. In particular, Akt phosphorylation is suppressed with downregulation of dysbindin and increased with upregulation of dysbindin. A nonsense mutation of dysbindin causes Hermansky-Pudlak disease, an autosomal recessive disorder characterized by lysosomal storage defects and prolonged bleeding. Genetic variation in the gene encoding dysbindin is strongly associated with schizophrenia and protein levels are reduced in the prefrontal cortex, midbrain and hippocampus of brains from patients with schizophrenia.

General readings

Haukvik, U.K., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 34(7):1259-1265(2010).
Voisey, J., et al. Eur. Psychiatry 25(6):314-319 (2010).
Ruano, G., et al. Pharmacogenomics 11(7):959-971 (2010).
Hashimoto, R., et al. Nihon Shinkei Seishin Yakurigaku Zasshi 30(3):103-107 (2010).
Voisey, J., et al. Behav Brain Funct 6, 41 (2010).

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