Dysferlin antibody

Principal name

Dysferlin antibody

Alternative names for Dysferlin antibody

Fer-1-like protein 1, DYSF, FER1L1, Dystrophy-associated fer-1-like protein

SwissProt ID

A6QQP7 (Bovin), O75923 (Human), Q9ESD7 (Mouse)

Gene ID

8291 (DYSF)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Rt (Rat), Chk (Chicken), Can (Canine), Por (Porcine)

Available hosts

Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Dysferlin antibody

Dysferlin is a muscle-specific protein that is essential for normal muscle function and development. Mutations in the human dysferlin gene, DYSF, which maps to chromosome 2p13.3-p13.1, are associated with limb girdle muscular dystrophy-2B (LGMD-2B) and a related, adult-onset, distal dystrophy known as Miyoshi myopathy (MM).
Dysferlin, a protein with a molecular mass of approximately 230 kDa, localizes to the muscle fiber membrane, but is absent in MM and LGMD-2B muscle. Dysferlin is detected in 5-6 week embryos, when limbs begin to form regional differentiation. Although it is not essential for initial myogenesis, dysferlin appears to be critical for sustained normal function in mature muscle. It has been suggested that the absence of dysferlin during development gives rise to the disease phenotype in adulthood. Identical mutations in the dysferlin gene can produce more than one myopathy phenotype, indicating that additional genes and/or other factors are also involved in the clinical phenotype.
The DYSF gene has no homology to any other known mammalian gene, but the protein product is related to the spermatogenesis factor fer-1 of Caenorhabditis elegans. The name ‘dysferlin’ combines the role of the gene in producing muscular dystrophy with its homology to C. elegans.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Dysferlin (2004-2021) antibody

Figure 1. Staining DYSF in Heart by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

Dysferlin antibody

  Rabbit polyclonal anti-Dysferlin antibody  
Western blot analysis of extracts from K562 cells, using Dysferlin antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Dysferlin antibody

  Rabbit Polyclonal Anti-Dysferlin Antibody  
Western blot analysis on K562 cell lysate using Dysferlin Antibody Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Dysferlin antibody

Western blot (WB) analysis of Dysferlin antibody (Cat.-No.: AP06090PU-N) at 1/500 dilution Lane1:MCF-7 cell lysate Lane2:sp2/0 cell lysate Lane3:Rat liver tissue lysate Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Dysferlin (C-term) antibody

Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu P, WB
0.25 ml / €470.00
  Acris Antibodies GmbH

Dysferlin antibody

Western blot analysis of extracts from K562 cells, using Dysferlin Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €230.00
  Assay Biotech

Dysferlin antibody

Western blot analysis of extracts from K562 cells, using Dysferlin Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

DYSF - human gene knockout kit via CRISPR

DYSF - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

DYSF - human gene knockout kit via CRISPR

DYSF - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

DYSF - human gene knockout kit via CRISPR

DYSF - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

DYSF - human gene knockout kit via CRISPR

DYSF - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Dysferlin (transcript variant 1)

  Recombinant protein of human dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) (DYSF), transcript variant 1  
Dysferlin Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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