Dystrophin / DMD antibody

Principal name

Dystrophin / DMD antibody

SwissProt ID

O97592 (Canfa), P11530 (Rat), P11531 (Mouse), P11532 (Human), P11533 (Chick), Q5GN48 (Pig)

Gene ID

1756 (DMD)

Available reactivities

Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Fi (Fish)

Available hosts

Mouse, Rabbit

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoelectron Microscopy (EM)

Background of Dystrophin / DMD antibody

Dystrophin(DMD) gene has 79 exons spanning at least 2,300 kb (2.3 Mb). The C terminus of the dystrophin protein is encoded by a highly conserved, alternatively spliced region of the gene. beta-dystroglycan binding activity is expressed by the dystrophin fragment spanning amino acids 3026-3345 containing the ZZ domain. DMD transcript is formed by at least 60 exons; the first half of the transcript is formed by a minimum of 33 exons spanning nearly 1000 kb, and the remaining portion has at least 27 exons that may spread over a similar distance. Dystrophin gene is expressed at a higher level in primary cultures of neuronal cells than in astro-glial cells derived from adult mouse brain.over expression of dystrophin prevents the development of the abnormal mechanical properties associated with dystrophic muscle without causing deleterious side effects.

General readings

1 Chelly, J.; Hamard, G.; Koulakoff, A.; Kaplan, J.-C.; Kahn, A.; Berwald-Netter, Y. : Dystrophin gene transcribed from different promoters in neuronal and glial cells. Nature 344: 64-65, 1990.
2 Cox, G. A.; Cole, N. M.; Matsumura, K.; Phelps, S. F.; Hauschka, S. D.; Campbell, K. P.; Faulkner, J. A.; Chamberlain, J. S. : Overexpression of dystrophin in transgenic mdx mice eliminates dystrophic symptoms without toxicity. Nature 364: 725-729, 1993.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Dystrophin / DMD antibody

  Rabbit polyclonal anti-Dystrophin antibody  
Western blot analysis of Dystrophin expression in 3T3 cell lysate (Lane 1) and rat kidney tissue lysate (Lane 2). Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €353.00
  OriGene Technologies, Inc.

Dystrophin / DMD antibody

  Rabbit Polyclonal Anti-DMD Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using (DMD Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €335.00
  OriGene Technologies, Inc.

2 Item(s)

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