Dystrophin / DMD antibody

Principal name

Dystrophin / DMD antibody

SwissProt ID

O97592 (Canfa), P11530 (Rat), P11531 (Mouse), P11532 (Human), P11533 (Chick), Q5GN48 (Pig)

Gene ID

1756 (DMD)

Available reactivities

Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Fi (Fish)

Available hosts

Mouse, Rabbit

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoelectron Microscopy (EM)

Background of Dystrophin / DMD antibody

Dystrophin(DMD) gene has 79 exons spanning at least 2,300 kb (2.3 Mb). The C terminus of the dystrophin protein is encoded by a highly conserved, alternatively spliced region of the gene. beta-dystroglycan binding activity is expressed by the dystrophin fragment spanning amino acids 3026-3345 containing the ZZ domain. DMD transcript is formed by at least 60 exons; the first half of the transcript is formed by a minimum of 33 exons spanning nearly 1000 kb, and the remaining portion has at least 27 exons that may spread over a similar distance. Dystrophin gene is expressed at a higher level in primary cultures of neuronal cells than in astro-glial cells derived from adult mouse brain.over expression of dystrophin prevents the development of the abnormal mechanical properties associated with dystrophic muscle without causing deleterious side effects.

General readings

1 Chelly, J.; Hamard, G.; Koulakoff, A.; Kaplan, J.-C.; Kahn, A.; Berwald-Netter, Y. : Dystrophin gene transcribed from different promoters in neuronal and glial cells. Nature 344: 64-65, 1990.
2 Cox, G. A.; Cole, N. M.; Matsumura, K.; Phelps, S. F.; Hauschka, S. D.; Campbell, K. P.; Faulkner, J. A.; Chamberlain, J. S. : Overexpression of dystrophin in transgenic mdx mice eliminates dystrophic symptoms without toxicity. Nature 364: 725-729, 1993.

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Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Dystrophin / DMD (transcript variant Dp140b)

  Recombinant protein of human dystrophin (DMD), transcript variant Dp140b  
Dystrophin / DMD Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Dystrophin / DMD (transcript variant Dp71ab)

  Recombinant protein of human dystrophin (DMD), transcript variant Dp71ab  
Dystrophin / DMD Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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