E2F7 antibody

Principal name

E2F7 antibody

Alternative names for E2F7 antibody

E2F-7, FLJ12981, Transcription factor E2F7, E2F transcription factor 7

SwissProt ID

D4A4D7, E1BE02, F6YVB9, Q5RIX9, Q6S7F2 (Mouse), Q96AV8 (Human)

Gene ID

52679 (E2f7), 144455 (E2F7)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Por (Porcine), Eq (Equine), GP (Guinea Pig), Gt (Goat), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Electrophoretic Mobility Shift Assay (EMSA), Immunoprecipitation (IP), Enzyme Immunoassay (E)

Background of E2F7 antibody

Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and D damage response. Mainly acts as a transcription repressor that binds D independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in D damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in D replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation.

General readings

de Bruin,A., et al., (2003) J. Biol. Chem. 278 (43), 42041-42049

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

E2F7 antibody

  Goat Anti-E2F7 Antibody  
TA305912 (0.1ug/ml) staining of Human Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Por E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

E2F7 antibody

  Anti-E2F7 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm, Nucleus. Positive control: Human gastric and colon cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using E2F7 antibody at dilution 1/60, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

E2F7 antibody

  Rabbit Polyclonal Anti-E2f7 Antibody  
Host: Rabbit; Target Name: E2f7; Sample Tissue: Rat Testis lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

E2F7 (Center) antibody

Western blot analysis of E2F7 Antibody Cat.-No AP51351PU-N in A2058 cell line lysates (35ug/lane). This demonstrates the E2F7 antibody detected the E2F7 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

E2F7 - human gene knockout kit via CRISPR

E2F7 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

E2F7 - human gene knockout kit via CRISPR

E2F7 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

E2F7 - human gene knockout kit via CRISPR

E2F7 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

E2F7 - human gene knockout kit via CRISPR

E2F7 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

E2f7 - mouse gene knockout kit via CRISPR

E2f7 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

E2f7 - mouse gene knockout kit via CRISPR

E2f7 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

E2f7 - mouse gene knockout kit via CRISPR

E2f7 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

E2F7 overexpression lysate

E2F7 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, E2F7 (mGFP-tagged)-Human E2F transcription factor 7 (E2F7), 200 uL, >10^7 TU/mL

Lenti ORF particles, E2F7 (mGFP-tagged)-Human E2F transcription factor 7 (E2F7), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, E2F7 (Myc-DDK-tagged)-Human E2F transcription factor 7 (E2F7), 200 uL, >10^7 TU/mL

Lenti ORF particles, E2F7 (Myc-DDK-tagged)-Human E2F transcription factor 7 (E2F7), 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, E2f7 (GFP-tagged) - Mouse E2F transcription factor 7 (E2f7), 200 uL, >10^7 TU/mL

Lenti ORF particles, E2f7 (GFP-tagged) - Mouse E2F transcription factor 7 (E2f7), 200 uL, >10^7 TU/mL  
200 µl / €1,660.00
  OriGene Technologies, Inc.

Lenti ORF particles, E2f7 (Myc-DDK-tagged) - Mouse E2F transcription factor 7 (E2f7), 200 uL, >10^7 TU/mL

Lenti ORF particles, E2f7 (Myc-DDK-tagged) - Mouse E2F transcription factor 7 (E2f7), 200 uL, >10^7 TU/mL  
200 µl / €1,490.00
  OriGene Technologies, Inc.

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