EBI3 / IL27B antibody

Principal name

EBI3 / IL27B antibody

Alternative names for EBI3 / IL27B antibody

IL-27 subunit beta, IL-27B, Interleukin-27 subunit beta, Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein

SwissProt ID

O35228 (Mouse), Q14213 (Human)

Gene ID

10148 (EBI3), 50498 (Ebi3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of EBI3 / IL27B antibody

The cytokine Interleukin 27 (IL-27) is produced in response to inflammation. It is made by activated antigen presenting cells including monocytes, endothelial cells, and dendritic cells. IL-27 consists of a heterodimeric combination of Epstein-Barr virus-induced molecule 3 (EBI3, or IL-27B) non-covalently linked with IL-27 p28 (or IL-27A). It is a regulator of T helper cell development and suppressor of T-cell proliferation. IL-27 has both pro- and anti-inflammatory properties. It can stimulate cytotoxic T cell activity and induce isotype switching in B-cells. It has diverse effects on innate immune cells. It induces monocytes and mast cells to secrete pro-inflammatory cytokines. When infection is present, IL-27 induces naive CD4+ T cells to proliferate and develop Th1 cell responses. As an anti-inflammatory regulator, IL-27 can inhibit Th1 or Th2 responses and restrict the strength and duration of adaptive immune responses.

The IL-27 p28 subunit, a 28 kDa glycoprotein belonging to the type I cytokine family, is homologous to IL-12 p35, IL-23 p19, and IL-6. The EBI3 (Epstein-Barr virus-induced molecule 3, or IL-27B) subunit is a 34 kDa glycoprotein containing two fibronectin type III domains, and belongs to the type I cytokine receptor family. It can exist as a homodimer and can also heterodimerize with IL-12 p35. It is homologous to the p40 subunit of IL-12 and IL-23 and to the extracellular domain of IL-6 R. EBI3 can heterodimerize also with IL-12 p35, or can exist as a homodimer.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

EBI3 / IL27B (C-term) antibody

Western blot analysis of EBI3 in K562 lysate with EBI3 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EBI3 / IL27B antibody

Western blot analysis of EBI3 in rat spleen tissue lysate with EBI3 antibody at 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EBI3 / IL27B antibody

Mouse IL-27 Recombinant Protein (lane 1) and mouse bone marrow-derived dendritic cells stimulated with LPS (lane 2) or left untreated (lane 3) were analyzed by SDS-PAGE followed by immunoblotting with 5 ug/ml of Anti-Mouse EBI3 (IL-27 subunit) Purified.  Bands were visualized with Anti-Rat IgG HRP . Rat DNT27 Purified Ms WB
25 µg / €120.00
  OriGene Technologies, Inc.

EBI3 / IL27B antibody

Western Blot: EBI3 Antibody [TA336876] - Analysis of EBI3 using TA336876 in 1) Daudi cell lysate using 2.0 ug/ml, 2) Ramos cell lysate at 2.0 ug/ml in the absence of immunizing peptide 3) Ramos cell lysate at 2.0 ug/ml in the presence of immunizing peptid Rabbit Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EBI3 / IL27B antibody

Western Blot: EBI3 Antibody (10J706) [TA336877] - Western blot testing of mouse EBI3 monoclonal antibody at 0.1 ug/ml on recombinant protein. Goat anti-rat Ig HRP secondary antibody  and ECL substrate solution were used for this test. Rat IgG2b 10J706 Purified Ms F, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EBI3 / IL27B antibody

Western Blot: EBI3 Antibody (10J763) [TA336878] - Western blot analysis of mouse thymus tissue using EBI3 antibody at a concentration of 1 ug/ml. Rat IgG2a 10J763 Purified Ms F, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EBI3 / IL27B antibody

Western Blot: EBI3 Antibody (10J803) [TA336879] - Western blot analysis of mouse thymus tissue using EBI3 antibody at a concentration of 1 ug/ml. Rat IgG2a 10J803 Purified Ms F, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EBI3 / IL27B antibody

Western Blot: EBI3 Antibody (10J811) [TA336880] - Western blot testing of mouse EBI3 monoclonal antibody at A) 0.1 ug/ml on recombinant protein and B) 3 ug/ml on recombinant mouse IL-35 protein Goat anti-rat Ig HRP secondary antibody  and PicoTect ECL sub Rat IgG2a 10J811 Purified Ms F, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EBI3 / IL27B antibody

Western Blot: EBI3 Antibody (5P6G8) [TA336881] - Analysis using EBI3 antibody. Mouse EBI recombinant protein (A) and lysate from mouse kidney (B) probed with EBI3 antibody at 0.5 and 5 ug/ml, respectively. Goat anti-rat Ig HRP secondary antibody and PicoT Rat IgG2b 5P6G8 Purified Ms F, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EBI3 / IL27B antibody

Western Blot: EBI3 Antibody (5P10D3) [TA336882] - Analysis using EBI3 antibody. Mouse EBI recombinant protein (A) and lysate from mouse kidney (B) probed with EBI3 antibody at 0.5 and 5 ug/ml, respectively. Goat anti-rat Ig HRP secondary antibody and Pico Rat IgG2b 5P10D3 Purified Ms F, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EBI3 / IL27B antibody

Western Blot: EBI3 Antibody (42N1G4) [TA337164] - analysis using EBI3 antibody. Human EBI3 recombinant protein (A) and human IL-35 recombinant protein (B) probed with EBI3 antibody at 5 ug/ml. Goat anti-mouse Ig HRP secondary antibody and PicoTect ECL sub Mouse IgG2b 42N1G4 Purified Hu F, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EBI3 / IL27B antibody

Western Blot: EBI3 Antibody (42N12F7) [TA337165] - Analysis using EBI3 antibody. Human EBI3 recombinant protein (A) and human IL-35 recombinant protein (B) probed with EBI3 antibody at 5 ug/ml. Goat anti-mouse Ig HRP secondary antibody and PicoTect ECL su Mouse 42N12F7 Purified Hu F, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EBI3 / IL27B antibody

Western Blot: EBI3 Antibody (15k8D10) [TA337166] - analysis of IL-35-Fc protein (A) and human Fc (B) using EBI3 antibody at 4 ug/ml. Mouse IgG1 15K8D10 Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EBI3 / IL27B antibody

Human Lyphoid-Dendritic Cells: Formalin-Fixed, Paraffin-Embedded (FFPE). Rat IgG2a DNT27 Aff - Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

EBI3 / IL27B Control Peptide

EBI3 / IL27B
50 µg / €160.00
  Acris Antibodies GmbH

EBI3 / IL27B Control Peptide

EBI3 / IL27B
50 µg / €160.00
  Acris Antibodies GmbH

EBI3 / IL27B antibody

EBI3 / IL27B Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

EBI3 / IL27B antibody

EBI3 polyclonal antibody (A02), Lot # 051011JC01 Western Blot analysis of EBI3 expression in HepG2 ( Cat # L019V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

EBI3 / IL27B antibody

Detection limit for recombinant GST tagged EBI3 is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 1D3 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

EBI3 / IL27B antibody

EBI3 / IL27B Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

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