ECRG-2 antibody

Principal name

ECRG-2 antibody

Alternative names for ECRG-2 antibody

SPINK7, ECG2, UNQ745/PRO1474, MGC133105, MGC133106, Serine protease inhibitor Kazal-type 7, Esophagus cancer-related gene 2 protein

SwissProt ID

P58062 (Human), Q6IE32 (Mouse), Q6IE51 (Rat)

Gene ID

84651 (SPINK7)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Chicken

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of ECRG-2 antibody

ECRG2 Antibody: The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus. It interacts directly with metallothionein 2A and urokise-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis. ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dymic association of uPAR with beta1 integrins and disrupting the Src/MAP kise pathway that normally stimulates cell migration and invasion. ECRG2 may thus represent a novel therapeutic target for cancer.

General readings

Cui Y, Wang J, Zhang X, et al. ECRG2, a novel candidate of tumor suppressor gene in the esophageal carcinoma, interacts directly with metallothionein 2A and links to apoptosis. Biochem. Biophys. Res. Commun. 2003; 302:904-15.

9 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ECRG-2 (C-term) antibody

Western blot analysis of ECRG2 in human lung tissue lysate with ECRG2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide. Chicken Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ECRG-2 (C-term) Control Peptide

Western blot analysis in human lung tissue lysate with ECRG2 antibody Cat.-No AP55561PU-N at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
50 µg / €160.00
  Acris Antibodies GmbH

ECRG-2 antibody

Immunohistochemistry-Paraffin: SPINK7 Antibody [NBP1-84015] Immunohistochemical staining of human vulva/anal skin shows strong cytoplasmic and membranous positivity in a subset of squamous epithelial cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ECRG-2

ECRG-2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ECRG-2 (20-85, His-tag)

ECRG-2 Human Purified > 85 % by SDS - PAGE E. coli
0.25 mg / €730.00
  Acris Antibodies GmbH

ECRG-2 (20-85, His-tag)

ECRG-2 Human Purified > 85 % by SDS - PAGE E. coli
50 µg / €300.00
  Acris Antibodies GmbH

ECRG-2

ECRG-2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ECRG-2

ECRG-2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

SPINK7 overexpression lysate

SPINK7 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

9 Item(s)

per page
  • LinkedIn