EDA2R / TNFRSF27 antibody

Principal name

EDA2R / TNFRSF27 antibody

Alternative names for EDA2R / TNFRSF27 antibody

XEDAR, EDA-A2 receptor, UNQ2448/PRO5727/PRO34080, Tumor necrosis factor receptor superfamily member 27, X-linked ectodysplasin-A2 receptor

SwissProt ID

Q8BX35 (Mouse), Q9HAV5 (Human)

Gene ID

60401 (EDA2R), 245527 (Eda2r)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Flow Cytometry (F), Paraffin Sections (P), EPair for Elisa (EPair)

Background of EDA2R / TNFRSF27 antibody

X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2) (1). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-kappaB and JNK pathways (2). Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis (3). The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment (3).

General readings

1. "Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors."
Yan M., Wang L.-C., Hymowitz S.G., Schilbach S., Lee J., Goddard A., de Vos A.M., Gao W.-Q., Dixit V.M. Science 290:523-527(2000).
2. "Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor." Sinha S.K., Zachariah S., Quinones H.I., Shindo M., Chaudhary P.M. J. Biol. Chem. 277:44953-44961(2002).
3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003).
4. "The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. Bentley D.R. Nature 434:325-337(2005).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

EDA2R / TNFRSF27 antibody

  Rabbit Polyclonal XEDAR Antibody  
Western blot analysis of XEDAR in 293 cell lysate with XEDAR antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EDA2R / TNFRSF27 antibody

  Rabbit Polyclonal Anti-EDA2R Antibody  
EDA2R / TNFRSF27 Rabbit IgG Purified Hu E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

EDA2R / TNFRSF27 antibody

Immunohistochemical staining of human skin with Rabbit anti Human XEDAR (AP05597PU-N) Rabbit IgG Purified Hu WB
0.1 mg / €320.00
  Acris Antibodies GmbH

EDA2R / TNFRSF27 antibody

Immunohistochemical staining of human skin with Rabbit anti Human XEDAR (AP05597PU-N) Rabbit IgG Purified Hu WB
50 µg / €280.00
  Acris Antibodies GmbH

EDA2R / TNFRSF27 antibody

AP07746PU-N EDA2R antibody staining of Formalin-Fixed Paraffin-Embedded Human Kidney at 2.5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

EDA2R / TNFRSF27 antibody

EDA2R / TNFRSF27 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

EDA2R / TNFRSF27 antibody

Western Blot analysis of EDA2R expression in transfected 293T cell line (H00060401-T01) by EDA2R MaxPab polyclonal antibody.

Lane 1: EDA2R transfected lysate(32.67 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), F, WB
50 µl / €370.00
  Abnova Taiwan Corp.

EDA2R / TNFRSF27 antibody

Western Blot analysis of EDA2R expression in transfected 293T cell line (H00060401-T02) by EDA2R MaxPab polyclonal antibody.

Lane 1: EDA2R transfected lysate(32.67 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), F, WB
50 µg / €370.00
  Abnova Taiwan Corp.

EDA2R / TNFRSF27 antibody

EDA2R MaxPab rabbit polyclonal antibody. Western Blot analysis of EDA2R expression in mouse liver. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

EDA2R / TNFRSF27 antibody

EDA2R monoclonal antibody (M02), clone 3C1. Western Blot analysis of EDA2R expression in Raw 264.7. Mouse IgG1 3C1 Purified Hu, Ms E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

EDA2R / TNFRSF27 antibody

Immunohistochemistry of EDA2R in human skin tissue with EDA2R polyclonal antibody ( Cat # PAB12963 ) at 10 µg/ml. Rabbit Hu P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

EDA2R / TNFRSF27 (1-138, His-tag)

EDA2R / TNFRSF27 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

EDA2R / TNFRSF27 (1-138, His-tag)

EDA2R / TNFRSF27 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

EDA2R / TNFRSF27

EDA2R / TNFRSF27 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

EDA2R / TNFRSF27

EDA2R / TNFRSF27 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

EDA2R / TNFRSF27

EDA2R / TNFRSF27 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

EDA2R / TNFRSF27

EDA2R / TNFRSF27 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Antibody Pairs

Catalog No.    

EDA2R (Human) Matched Antibody Pair

EDA2R (Human) Matched Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

EDA2R 293T Cell Transient Overexpression Lysate(Denatured)

EDA2R 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

EDA2R overexpression lysate

EDA2R overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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