EDA2R / TNFRSF27 antibody

Principal name

EDA2R / TNFRSF27 antibody

Alternative names for EDA2R / TNFRSF27 antibody

XEDAR, EDA-A2 receptor, UNQ2448/PRO5727/PRO34080, Tumor necrosis factor receptor superfamily member 27, X-linked ectodysplasin-A2 receptor

SwissProt ID

Q8BX35 (Mouse), Q9HAV5 (Human)

Gene ID

60401 (EDA2R)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Flow Cytometry (F), Paraffin Sections (P), EPair for Elisa (EPair), Neutralisation (NEUT)

Background of EDA2R / TNFRSF27 antibody

The tumor necrosis factor receptor (TNFR) superfamily represents a growing family of type I transmembrane glycoproteins that are involved in various cellular functions, including proliferation, differentiation and programmed cell death (1–3). These proteins share homology for cysteine-rich repeats in the extracellular ligand binding domain and an intracellular death domain (1–3). Members of the TNFR superfamily transmit signals through protein-protein interactions, and these signals can lead to the activation of either the caspase and Jun kinase pathways, which promote cell death, or the NFkB pathway, which results in cell survival (1). The ectodermal dysplasia receptor (EDAR) promotes all three of these pathways and mediates ectodermal differentiation (4). EDAR is encoded by the downless gene and is mutated in ectodermal dysplasia syndromes, which are characterized by impaired hair, teeth and sweat gland development (5). Ectodysplasin A (EDA) is a type II membrane protein that is encoded by the Tabby gene and produces many splice variants, the longest of which, EDA-A1, serves as the ligand for EDAR (5–7). EDA-A2, which differs from EDA-A1 by the deletion of two amino acids, binds only the X-linked ectodysplasin-A2 receptor (XEDAR) (7). Both EDAR and XEDAR exhibit homology with TROY (8).

General readings

1. "Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors."
Yan M., Wang L.-C., Hymowitz S.G., Schilbach S., Lee J., Goddard A., de Vos A.M., Gao W.-Q., Dixit V.M. Science 290:523-527(2000).
2. "Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor." Sinha S.K., Zachariah S., Quinones H.I., Shindo M., Chaudhary P.M. J. Biol. Chem. 277:44953-44961(2002).
3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003).
4. "The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. Bentley D.R. Nature 434:325-337(2005).

20 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

EDA2R / TNFRSF27 antibody

Western blot analysis of XEDAR in 293 cell lysate with XEDAR antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EDA2R / TNFRSF27 antibody

Immunohistochemical staining of human skin with Rabbit anti Human XEDAR (AP05597PU-N) Rabbit IgG Purified Hu WB
0.1 mg / €320.00
  Acris Antibodies GmbH

EDA2R / TNFRSF27 antibody

Immunohistochemical staining of human skin with Rabbit anti Human XEDAR (AP05597PU-N) Rabbit IgG Purified Hu WB
50 µg / €280.00
  Acris Antibodies GmbH

EDA2R / TNFRSF27 antibody

AP07746PU-N EDA2R antibody staining of Formalin-Fixed Paraffin-Embedded Human Kidney at 2.5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

EDA2R / TNFRSF27 antibody

EDA2R / TNFRSF27 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

EDA2R / TNFRSF27 antibody

Western Blot analysis of EDA2R expression in transfected 293T cell line (H00060401-T01) by EDA2R MaxPab polyclonal antibody.

Lane 1: EDA2R transfected lysate(32.67 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), F, WB
50 µl / €370.00
  Abnova Taiwan Corp.

EDA2R / TNFRSF27 antibody

Western Blot analysis of EDA2R expression in transfected 293T cell line (H00060401-T02) by EDA2R MaxPab polyclonal antibody.

Lane 1: EDA2R transfected lysate(32.67 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), F, WB
50 µg / €370.00
  Abnova Taiwan Corp.

EDA2R / TNFRSF27 antibody

EDA2R MaxPab rabbit polyclonal antibody. Western Blot analysis of EDA2R expression in mouse liver. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

EDA2R / TNFRSF27 antibody

EDA2R monoclonal antibody (M02), clone 3C1. Western Blot analysis of EDA2R expression in Raw 264.7. Mouse IgG1 3C1 Purified Hu, Ms E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

EDA2R / TNFRSF27 antibody

Immunohistochemistry of EDA2R in human skin tissue with EDA2R polyclonal antibody ( Cat # PAB12963 ) at 10 µg/ml. Rabbit Hu P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

EDA2R / TNFRSF27 antibody

Immunohistochemistry-Paraffin: EDA2R Antibody [NBP1-76710] - Human skin tissue with XEDAR antibody at 10 ug/mL._x000d_ Rabbit Aff - Purified Hu E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

EDA2R / TNFRSF27 (1-138, His-tag)

EDA2R / TNFRSF27 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

EDA2R / TNFRSF27 (1-138, His-tag)

EDA2R / TNFRSF27 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

EDA2R / TNFRSF27

EDA2R / TNFRSF27 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

EDA2R / TNFRSF27

EDA2R / TNFRSF27 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

EDA2R / TNFRSF27

EDA2R / TNFRSF27 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

EDA2R / TNFRSF27

EDA2R / TNFRSF27 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Antibody Pairs

Catalog No.    

EDA2R (Human) Matched Antibody Pair

EDA2R (Human) Matched Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

EDA2R 293T Cell Transient Overexpression Lysate(Denatured)

EDA2R 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

EDA2R overexpression lysate

EDA2R overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

20 Item(s)

per page
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