EDG3 / S1P3 antibody

Principal name

EDG3 / S1P3 antibody

Alternative names for EDG3 / S1P3 antibody

S1P receptor 3, S1PR3, EDG3, LPB3, FLJ37523, FLJ93220, MGC71696, Sphingosine 1-phosphate receptor 3, Endothelial differentiation G-protein coupled receptor 3

SwissProt ID

Q99500 (Human), Q9Z0U9 (Mouse)

Gene ID

1903 (S1PR3), 13610 (S1pr3)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), GP (Guinea Pig), Rb (Rabbit), Ze (Zebrafish), Mky (Monkey)

Available hosts

Mouse, Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Flow Cytometry (F)

Background of EDG3 / S1P3 antibody

Sphingosine 1-phosphate (S1P) is an active byproduct of sphingomyelin metabolism. All cells can synthesize this biomolecule but the majority of its synthesis comes from erythrocytes and endothelial cells. In cases of inflammation, mast cells and platelets are the main source of sphingosine 1-phosphate. S1P cellular functions could be intracellular, where it is synthesized. In addition, upon secretion, it circulates in the blood via its binding to high-density lipoproteins and albumin. When S1P reaches its target cell it could activate 5 different high affinity receptors belonging to the G-protein coupled receptor superfamily: Sphingosine 1-phosphate receptors, termed S1PR1-5 . Stimulation of S1PR receptors triggers a cascade of sigling events depending on the receptor and on the G-protein it couples. S1PR1 couples to Gi. S1PR2 can couple to Gs, Gq or G12/13 and S1PR3-5 can couple to Gi or G12/13. The pathways activated vary from Ca2+ mobilization, activation or inhibition of adenylate cyclase phospholipase C activation and more. Through the different sigling pathways these receptors activate, S1P1R receptors are implicated in adherens junction assembly, cytoskeletal changes, cell migration, proliferation and apoptosis. S1PR3 is specifically detected in the brain, heart, spleen, liver, lung, thymus, kidney, testis and skeletal muscle. S1PR1 and S1PR2 are generally expressed in the CNS, cardiovascular and immune systems. S1PR4 is specifically expressed in the lymphoid tissue and S1PR5 in tural killer cells and olygodendrocytes. Malfunction of S1PR receptor sigling is reported in various disorders, for example multiple sclerosis and may be targets for the development of therapeutic drugs.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

EDG3 / S1P3 antibody

Western blot analysis of extracts from Jurkat cells, using EDG3 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

EDG3 / S1P3 antibody

Predicted band size: 42 kDa. Positive control: PC3 cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 50 ug per lane Primary antibody: 1/550 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 20 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

EDG3 / S1P3 antibody

Predicted band size: 42 kDa. Positive control: Human fetal brain tissue lysate. Recommended dilution: 1/1000-5000. (Gel: 10%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/700 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 20 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

EDG3 / S1P3 antibody

TA326312 (2µg/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. Goat Aff - Purified Hu P
0.1 mg / €325.00
  OriGene Technologies, Inc.

EDG3 / S1P3 antibody

Western blot analysis of rat heart (lanes 1 and 3), rat kidney (lanes 2 and 4), Jurkat (lanes 5 and 7) and WEHI (lanes 6 and 8) lysates: 1, 2, 5, 6. Anti-Sphingosine 1-Phosphate Receptor 3 (extracellular) antibody, (1:200). 3, 4, 7, 8. Anti-Sphingosine 1-Phosphate Receptor 3 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

EDG3 / S1P3 antibody

WB Suggested Anti-S1PR3 Antibody; Titration: 1.0 ug/ml; Positive Control: Hela Whole Cell Rabbit IgG Purified GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

EDG3 / S1P3 antibody

Western Blot: EDG3 Antibody [TA337062] - analysis of Sphingolipid Receptor Edg3/S1P3 in kidney lysate. Lane 1 shows pre-immune sera. Lanes 2 and 3 show this antibody. I goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were us Rabbit IgG Purified Hu, Ms P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EDG3 / S1P3 antibody

Anti-EDG3 / S1P3 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky
50 µg / €379.00
  OriGene Technologies, Inc.

EDG3 / S1P3 antibody

Anti-EDG3 / S1P3 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky
50 µg / €379.00
  OriGene Technologies, Inc.

EDG3 / S1P3 antibody

Anti-SIPR3 / EDG3 / S1P3 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky
50 µg / €379.00
  OriGene Technologies, Inc.

EDG3 / S1P3 (C-term) antibody

Known Reactivities of EDG antibodies by Western Blotting Mouse IgG AS61 Purified Hu, Rt WB
0.1 mg / €570.00
  Acris Antibodies GmbH

EDG3 / S1P3 antibody

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 2G11 Purified Hu E, P
50 µg / €530.00
  Acris Antibodies GmbH

EDG3 / S1P3 antibody

Western blot analysis of EDG-3 Antibody (Cat.-No AP01309PU-N) in extracts from HT-29 cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

EDG3 / S1P3 antibody

Western blot (WB) analysis of EDG-3 antibody (Cat.-No.: AP01423PU-N) in extracts from Jurkat cells. Rabbit Aff - Purified Hu WB
0.1 mg / €350.00
  Acris Antibodies GmbH

EDG3 / S1P3 antibody

EDG3 / S1P3 Rabbit Purified Hu WB
0.1 mg / €570.00
  Acris Antibodies GmbH

EDG3 / S1P3 antibody

EDG3 / S1P3 Rabbit Purified Hu WB
0.1 mg / €570.00
  Acris Antibodies GmbH

EDG3 / S1P3 antibody

AP07705PU-N EDG3 antibody staining of Formalin-Fixed Paraffin-Embedded Human Kidney at 20 µg/ml followed by biotinylated Goat anti-Rabbit IgG secondary antibody, Alkaline Phosphatase-Streptavidin and Chromogen. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

EDG3 / S1P3 (N-term) antibody

The anti-EDG3 Antibody (N-term) is used in Western blot to detect EDG3 in Mouse kidney lysate. Rabbit Ig Purified Hu, Ms WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

EDG3 / S1P3 antibody

Western Blot analysis of S1PR3 expression in transfected 293T cell line (H00001903-T01) by S1PR3 MaxPab polyclonal antibody.

Lane 1: EDG3 transfected lysate(41.58 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), F, WB
50 µg / €370.00
  Abnova Taiwan Corp.

EDG3 / S1P3 antibody

EDG3 / S1P3 Mouse IgG1 2G11 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

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