EDG8 / S1P5 antibody

Principal name

EDG8 / S1P5 antibody

Alternative names for EDG8 / S1P5 antibody

S1P receptor 5, EDG8, SPPR-1, SPPR-2, S1PR5, Endothelial differentiation G-protein-coupled receptor 8

SwissProt ID

Q684M3 (Pig), Q91X56 (Mouse), Q9H228 (Human), Q9JKM5 (Rat)

Gene ID

53637 (S1PR5), 94226 (S1pr5), 60399

Available reactivities

Hu (Human), Can (Canine), Dros (Drosophila), Ms (Mouse), Por (Porcine), Rt (Rat), Ze (Zebrafish), Bov (Bovine), Prim (Primate), Bt (Bat), Hst (Hamster), Mky (Monkey), Gorilla

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of EDG8 / S1P5 antibody

EDG8 is a receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. It Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). It may play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.

General readings

Guinn,B.A., (2005) Biochem. Biophys. Res. Commun. 335 (4), 1293-1304

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

EDG8 / S1P5 antibody

AP32969PU-N (1µg/ml) staining of Human Frontal Cortex (A) and Amygdala (B) lysates (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Por WB
0.1 mg / €350.00
  Acris Antibodies GmbH

EDG8 / S1P5 antibody

  Anti-S1PR5 Rabbit Polyclonal Antibody  
Predicted band size: 42 kDa. Positive control: Human brain malignant glioma tissue and MCF7 cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lane1: Human brain malignant glioma tissue lysate Lane2: MCF7 cell lysate Lysates: 40 ug per lane Primary antibody: 1/750 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 20 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

EDG8 / S1P5 antibody

  Rabbit Polyclonal S1P5/EDG-8 Antibody  
Western Blot: EDG8 Antibody [TA337040] - Analysis of EDG8 in human brain lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse, 4) rat using TA337040 at 5 ug/ml, 2 ug/ml and 2 ug/ml. Rabbit IgG Purified Can, Hu, Ms, Prim, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EDG8 / S1P5 (N-term Extracel. Dom.) antibody

  Rabbit Polyclonal Anti-S1PR5 Antibody (N-Terminus)  
Anti-S1PR5 / EDG8 antibody IHC of rat brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bov, Bt, Can, Gorilla, Hst, Hu, Mky, Ms, Por, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

EDG8 / S1P5 (2nd Cytopl. Dom.) antibody

  Rabbit Polyclonal Anti-S1PR5 Antibody (Cytoplasmic Domain)  
Anti-S1PR5 / EDG8 antibody IHC of human brain, neuron and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bt, Can, Hst, Hu, Ms, Prim, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

EDG8 / S1P5 antibody

Western blot analysis using anti-EDG-8 CT antibody on RH7777 cell lysates transfected with full length human EDG-8 (1) and blocked with blocking peptide (2) using Pierce Femto Signal substrate. Rabbit IgG Purified Hu WB
0.1 mg / €590.00
  Acris Antibodies GmbH

EDG8 / S1P5 antibody

AP07708PU-N EDG8 antibody staining of Formalin-Fixed Paraffin-Embedded Human Skeletal Muscle. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

EDG8 / S1P5 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using EDG8 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, P
50 µg / €230.00
  Assay Biotech

EDG8 / S1P5 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using EDG8 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, P
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

S1PR5 - human gene knockout kit via CRISPR

S1PR5 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

S1PR5 - human gene knockout kit via CRISPR

S1PR5 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

S1PR5 - human gene knockout kit via CRISPR

S1PR5 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

S1PR5 - human gene knockout kit via CRISPR

S1PR5 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

S1pr5 - mouse gene knockout kit via CRISPR

S1pr5 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

S1pr5 - mouse gene knockout kit via CRISPR

S1pr5 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

S1pr5 - mouse gene knockout kit via CRISPR

S1pr5 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

S1pr5 - mouse gene knockout kit via CRISPR

S1pr5 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

S1PR5 overexpression lysate

S1PR5 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

S1PR5 overexpression lysate

S1PR5 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, S1PR5 (mGFP-tagged) - Human sphingosine-1-phosphate receptor 5 (S1PR5), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, S1PR5 (mGFP-tagged) - Human sphingosine-1-phosphate receptor 5 (S1PR5), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

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