EGFR / ERBB1 antibody

Principal name

EGFR / ERBB1 antibody

Alternative names for EGFR / ERBB1 antibody

Epidermal growth factor receptor, EGF Receptor, erbB-1, c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, Proto-oncogene c-ErbB-1

SwissProt ID

P00533 (Human), P13387 (Chick), Q01279 (Mouse)

Gene ID

1956 (EGFR), 13649 (Egfr)

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Rt (Rat), Chk (Chicken), Mky (Monkey), Por (Porcine), Bov (Bovine), Ze (Zebrafish)

Available hosts

Mouse, Rat, Sheep, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Flow Cytometry (F), Paraffin Sections (P), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot), ELISA (detection) (E(detection)), Immunoelectron Microscopy (EM), Luminex (LMNX)

Background of EGFR / ERBB1 antibody

Epidermal growth factor receptor (EGFR) is a transmembrane receptor for epidermal growth factor (EGF). It is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB -1), HER2/c-neu (ErbB-2) Her 3 (ErbB-3 and Her 4 (ErbB-4). EGFR exists on the cell surface as inactive monomers and is activated by binding of its specific ligands, including EGF, transforming growth factor alpha (TGFalpha), or others. Upon activation, EGFR can pair with another EGFR to form an active homodimer or an EGFR may pair with another member of the ErbB receptor family, such as Her 2/c-neu, to create a heterodimer. Evidence also suggests that a cluster of active EGFR can form. (Ref.1-3) The binding of ligand stimulates the intrinsic protein-tyrosine kinase activity of EGFR which initiates a signal transduction cascade leading to DNA synthesis and cell proliferation. The kinase activity can also result in autophosphorylation of the five tyrosine residues in the C-terminal domain of EGFR. Autophosphorylation elicits downstream activation and signaling events of other proteins that are often distinct from those activated by the kinase domain of EGFR. Such proteins modulate phenotypes such as cell migration, adhesion, and proliferation.
The kinase domain of EGFR can also cross-phosphorylate tyrosine residues of other receptors it is aggregated with, and can itself be activated in this manner.
Mutations that lead to EGFR overexpression or overactivity have been associated with many common solid human squamous cell carcinomas including breast, brain, bladder, lung, gastric, head and neck, esophagus, cervix, vulva, ovary, and endometrium. (Ref.4-7) EGFR and ErbB -2 are particularly important in breast cancer because increased production or activation has been associated with poor prognosis. Tumor aggressiveness and patient outcome can be directly correlated to the production levels. Inhibitors of EGFR represent an emerging new class of anti-cancer drugs that target the underlying molecular changes involving oncogenes and tumor suppressor genes, genes that play critical roles in the conversion of normal cells into a cancerous state.

General readings

Her-2/neu and EGFR tyrosine kinase activation predict the efficacy of trastuzumab-based therapy in patients with metastatic breast cancer. Hudelist G, Köstler J, Czerwenka K, Kubista E, Attems J, Müller R, Gschwantler-Kaulich D, Manavi M, Huber I, Hoschützky H, Zielinski CC, Singer CF. Int. J. Cancer:118, 1126-1134 (2006).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

EGFR / ERBB1 pSer1047 (incl. pos. control) antibody

EGFR Transactivation: Serum starved HepG2 cells were treated for 15min as indicated . Whole cell lysates were separated by SDS-PAGE (ca 20.000 cells/lane). The immunoblot was probed with mab EGFR-1H9 (0.5 µg/ ml) for 1h at RT and developed by ECL (exp. time: 30 sec).
Lane 1: Control 
Lane 2: PMA 
Lane 3: Forskolin 
Lane 4: LPA
Lane 5: Sorbit 
Lane 6; Anisomycin 
Lane 7: Ionomycin 
Lane 8: Taxol Mouse IgG1 1H9 Purified Can, Hu, Ms E, ICC/IF, IP, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

EGFR / ERBB1 antibody

Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue using EGFR antibody Cat.-No AP02613PU (left) or the same antibody preincubated with blocking peptide (right) Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

EGFR / ERBB1 antibody

Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue using EGFR antibody Cat.-No AP02613PU (left) or the same antibody preincubated with blocking peptide (right) Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

EGFR / ERBB1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-EGFR mouse monoclonal antibody. (UM500070; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB95 Purified Can, Hu, Mky P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

EGFR / ERBB1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-EGFR mouse monoclonal antibody. (UM500070; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB95 Purified Can, Hu, Mky P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

EGFR / ERBB1 (C-term) antibody

Anti-EGFR antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

EGFR / ERBB1 antibody

Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-EGFR mouse monoclonal antibody. (TA506224) Mouse IgG1 OTI3H2 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

EGFR / ERBB1 antibody

Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-EGFR mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801955) Mouse IgG1 OTIE3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

EGFR / ERBB1 (C-term) antibody

AM21065PU EGFR antibody staining of Human Colon Adenocarcinoma. Rabbit IgG SP84 Purified Hu P, WB
0.5 ml / €520.00
  Acris Antibodies GmbH

EGFR / ERBB1 (C-term) antibody

AM21065PU EGFR antibody staining of Human Colon Adenocarcinoma. Rabbit IgG SP84 Purified Hu P, WB
1 ml / €750.00
  Acris Antibodies GmbH

EGFR / ERBB1 (C-term) antibody

AM21065PU EGFR antibody staining of Human Colon Adenocarcinoma. Rabbit IgG SP84 Purified Hu P, WB
0.1 ml / €300.00
  Acris Antibodies GmbH

EGFR / ERBB1 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human placenta (A, 4 μm) and squamous cell skin carcinoma (B, 4 μm) stained with anti-EGFR antibody (DB 092) shows strong positive membrane immunostaining of syncytiotrophoblasts (A) and strong membrane staining of tumor cells (B). Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG A20-E Aff - Purified Hu C, P
0.1 ml / €280.00
  DB Biotech, spol. s r.o.

Sample sizes available

EGFR / ERBB1 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human placenta (A, 4 μm) and squamous cell skin carcinoma (B, 4 μm) stained with anti-EGFR antibody (DB 092) shows strong positive membrane immunostaining of syncytiotrophoblasts (A) and strong membrane staining of tumor cells (B). Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG A20-E Aff - Purified Hu C, P
0.2 ml / €370.00
  DB Biotech, spol. s r.o.

Sample sizes available

EGFR / ERBB1 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human placenta (A, 4 μm) and squamous cell skin carcinoma (B, 4 μm) stained with anti-EGFR antibody (DB 092) shows strong positive membrane immunostaining of syncytiotrophoblasts (A) and strong membrane staining of tumor cells (B). Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG A20-E Aff - Purified Hu C, P
0.5 ml / €460.00
  DB Biotech, spol. s r.o.

Sample sizes available

EGFR / ERBB1 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human placenta (A, 4 μm) and squamous cell skin carcinoma (B, 4 μm) stained with anti-EGFR antibody (DB 092) shows strong positive membrane immunostaining of syncytiotrophoblasts (A) and strong membrane staining of tumor cells (B). Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG A20-E Aff - Purified Hu C, P
1 ml / €720.00
  DB Biotech, spol. s r.o.

Sample sizes available

EGFR / ERBB1 (C-term) antibody

Human placenta stained with EGFR Antibody Cat.-No AM11132PU (Clone SP9) Rabbit SP9 Supernatant Hu F, P
1 ml / €560.00
  Acris Antibodies GmbH

EGFR / ERBB1 (C-term) antibody

Human placenta stained with EGFR Antibody Cat.-No AM11132PU (Clone SP9) Rabbit SP9 Supernatant Hu F, P, WB

Regular Price: 0.2 ml / €200.00

Special Price: 0.2 ml / €140.00

  Acris Antibodies GmbH

EGFR / ERBB1 antibody

Formalin-Fixed, Paraffin-Embedded Human breast tissue stained with EGFR Antibody Cat.-No AM32821PU (Clone GFR450). Mouse IgG2a GFR450 Purified Hu F, ICC/IF, P
0.2 mg / €390.00
  Acris Antibodies GmbH

EGFR / ERBB1 antibody

Formalin-Fixed, Paraffin-Embedded Human breast tissue stained with EGFR Antibody Cat.-No AM32821PU (Clone GFR450). Mouse IgG2a GFR450 Purified Hu F, ICC/IF, P
0.1 mg / €320.00
  Acris Antibodies GmbH

EGFR / ERBB1 antibody

Formalin-Fixed, Paraffin-Embedded Human breast tissue stained with EGFR Antibody Cat.-No AM32821PU (Clone GFR450). Mouse IgG2a GFR450 Purified Hu F, ICC/IF, P
20 µg / €160.00
  Acris Antibodies GmbH

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