EGR2 antibody

Principal name

EGR2 antibody

Alternative names for EGR2 antibody

Early growth response protein 2, EGR-2, AT591, KROX20, Krox 20, Zinc finger protein Krox-20

SwissProt ID

A1XSY8 (Pig), P08152 (Mouse), P11161 (Human), P51774 (Rat)

Gene ID

1959 (EGR2)

Available reactivities

Can (Canine), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Ze (Zebrafish), Bov (Bovine), Eq (Equine), Hst (Hamster), Mky (Monkey), Prim (Primate), Rb (Rabbit), Bear

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Flow Cytometry (F)

Background of EGR2 antibody

EGR2 (E3 SUMO-protein ligase EGR2) protein is a member of EGR C2H2-type zinc-finger family and is a sequence-specific D-binding transcription factor that binds to two specific D sites located in HOXA4 promotor. EGR2 is an E3 SUMO-protein ligase that facilitates SUMO1 conjugation to its coregulators B1/B2, whose sumoylation down-regulates EGR2's own transcriptiol activity. EGR2 interacts with HCFC1, UBC9 and WWP2, and WWP2 mediated ubiquitinization of EGR2 results in its proteasomal degradation. EGR2 protein activates several genes which are implicated in the formation and maintence of myelin, the fatty substance that covers and protects nerve cells. EGR2 is considered a "master" transcription factor that regulates PNS myelition and plays a key role in myelin homeostasis. Besided peripheral nerve myelition, EGR2 plays important role in T cell maturation, hindbrain segmentation, and lipid biosynthesis. Genetic alteration of EGR2 results in a variety of relatively severe demyeliting neuropathies such as congenital hypomyeliting neuropathy (CHN), childhood-onset Dejerine-Sottas neuropathy (DSN), and Charcot-Marie-Tooth disease type 1D (CMT1D).

General readings

LeBlanc SE, Ward RM, Svaren J.Neuropathy-associated Egr2 mutants disrupt cooperative activation of myelin protein zero by Egr2 and Sox10.Mol Cell Biol. 2007 May;27(9):3521-9. Epub 2007 Feb 26.PMID: 17325040

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

EGR2 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-EGR2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505382) Mouse IgG1 OTI1B12 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

EGR2 antibody

TA303254 (0.03µg/ml) staining of HepG2 cell lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EGR2 antibody

Western blot analysis of extracts from K562 cells, using EGR2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

EGR2 antibody

WB Suggested Anti-EGR2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Lung Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

EGR2 antibody

Western Blot: EGR2 Antibody [TA336535] - Detection of EGR2 in human fetal lung tissue using TA336535. Rabbit Purified Hu, Por ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

EGR2 antibody

Western blot analysis on HeLa cell lysate using EGR2 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EGR2 antibody

Anti-EGR2 mouse monoclonal antibody (TA505319) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY EGR2(RC212183). Mouse IgG2b OTIF10 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

EGR2 (239-251) antibody

Human Colon (formalin-fixed, paraffin-embedded) stained with EGR2 antibody AP22550PU-N at 3.75 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bear, Bov, Can, Elephant, Eq, Hst, Hu, Mky, Ms, Por, Prim, Rb, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

EGR2 antibody

EGR2 Rabbit Serum Ms C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

EGR2 antibody

Western Blot analysis of EGR2 expression in transfected 293T cell line (H00001959-T01) by EGR2 MaxPab polyclonal antibody.

Lane 1: EGR2 transfected lysate(52.36 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

EGR2 antibody

EGR2 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

EGR2 antibody

Immunofluorescence of purified MaxPab antibody to EGR2 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

EGR2 antibody

Western Blot analysis of EGR2 expression in transfected 293T cell line (H00001959-T01) by EGR2 MaxPab polyclonal antibody.

Lane 1: EGR2 transfected lysate(50.30 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

EGR2 antibody

EGR2 monoclonal antibody (M03), clone 1G5. Western Blot analysis of EGR2 expression in rat brain. Mouse IgG2b 1G5 Purified Hu, Rt E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

EGR2 antibody

EGR2 polyclonal antibody ( Cat # PAB7314 ) ( 0.03 µg/ml ) staining of HepG2 cell lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

EGR2 antibody

Western blot analysis of EGR2 in human fetal lung tissue using EGR2 polyclonal antibody ( Cat # PAB12439 ). Rabbit Hu WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

EGR2 antibody

Human Lung; . Rabbit Anti-EGR2 Antibody. . Catalog Number:. P100880 . Paraffin Embedded Tissue: Human bronchiole epithelium . Cellular Data: Epithelial cells of renal tubule. Antibody Concentration: 4.0-8.0 ug/ml. Magnification: 400X Rabbit Aff - Purified Can, Hu, Ms, Por, Rt, Ze P, WB
50 µg / €350.00
  AVIVA Systems Biology

EGR2 (200-300) antibody

Detection of EGR2 in human fetal lung tissue. Rabbit IgG Aff - Purified Hu WB
0.1 ml / €380.00
  Neuromics Antibodies

EGR2 antibody

NB100-68146 (0.03µg/ml) staining of HepG2 cell lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Aff - Purified Hu E, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

EGR2 antibody

EGR2 Rabbit Biotin Hu, Por WB
0.1 ml / €360.00
  Novus Biologicals Inc.

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