EIF2A / EIF2S1 antibody

Principal name

EIF2A / EIF2S1 antibody

Alternative names for EIF2A / EIF2S1 antibody

EIF2-A, eIF-2A, eIF-2-alpha, eIF-2alpha, eIF2 alpha, Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha

SwissProt ID

P05198 (Human), P20459 (Yeast), P20460 (Pig), P41374 (Drome), P56286 (Schpo), P68101 (Rat), P68102 (Bovin), P83268 (Rabit), Q5ZLX2 (Chick), Q6ZWX6 (Mouse), Q7ZTK4 (Xenla)

Gene ID

1965 (EIF2S1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Ze (Zebrafish), African clawed frog, Dros (Drosophila), Mky (Monkey), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunoprecipitation (IP), Paraffin Sections (P), Dot blot (Dot), Frozen Sections (C)

Background of EIF2A / EIF2S1 antibody

The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. The eukaryotic initiation complex is composed of three subunits, designated eIF2alpha, eIF2beta and eIF2gamma (eukaryotic translation initiation factor 2 alpha, beta and gamma, respectively), all of which work in concert to form a ternary complex with GTP and tRNA in the early stages of protein synthesis. eIF2alpha, also known as EIF2S1 or EIF2, is a 315 amino acid subunit of the eukaryotic initiation complex that functions to bind tRNA to the 40S ribosomal subunit (in a GTP-dependent manner), thereby initiating translation. In addition, the phosphorylation state of eIF2alpha controls the rate of tRNA translation. When eIF2alpha is not phosphorylated, translation occurs at a normal rate. However, upon phosphorylation by one of several kinases, eIF2alpha is stabilized, thus preventing the GDP/GTP exchange reaction and slowing translation.

General readings

Kimball, S.R. (1999) Int. J. Biochem. Cell Biol. 31, 25-29.
De Haro, C. et al. (1996) FASEB J. 10, 1378-1387.
Sheikh, M.S. and Fornace Jr., A.J. (1999) Oncogene 18, 6121-6128.
Cheshire, J.L. et al. (1999) J. Biol. Chem. 274, 4801-4806.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

EIF2A / EIF2S1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-EIF2S1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501313, Dilution 1:50) Mouse IgG1 OTI3H4 Purified Can, Hu, Mky, Rt F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

EIF2A / EIF2S1 antibody

Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-EIF2S1 monoclonal antibody. Mouse IgG1 OTI3H7 Purified Can, Hu, Mky, Rt F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

EIF2A / EIF2S1 antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-EIF2S1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501373, Dilution 1:50) Mouse IgG1 OTI1B10 Purified Can, Hu, Mky, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

EIF2A / EIF2S1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-EIF2S1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501374, Dilution 1:50) Mouse IgG1 OTI5A5 Purified Can, Hu, Mky, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

EIF2A / EIF2S1 antibody

Immunohistochemical staining of paraffin-embedded Human thyroid tissue within the normal limits using anti-EIF2S1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501401, Dilution 1:50) Mouse IgG1 OTI5D10 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

EIF2A / EIF2S1 antibody

Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-EIF2S1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501402) Mouse IgG1 OTI1H1 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

EIF2A / EIF2S1 antibody

Immunofluorescence of monoclonal antibody to EIF2S1 on HeLa cell. [antibody concentration 10 ug/ml] Mouse IgG1 3H12-C11 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

EIF2A / EIF2S1 antibody

Predicted band size: 36 kDa . Positive control: 3T3, Hela and C6 cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 10%SDS-PAGE Lane1: 3T3 cells lysate Lane2: Hela cells lysate Lane3: C6 cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

EIF2A / EIF2S1 antibody

Western blot analysis of eIF2 alpha expression in IFN-a treated K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

EIF2A / EIF2S1 antibody

Western blot detection of eIF2a in C2C12,MCF7,C6 and Hela cell lysates using eIF2a mouse mAb (1:1000 diluted).Predicted band size:38KDa.Observed band size:38KDa. Mouse IgG2b 2E4-F5-E7 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

EIF2A / EIF2S1 antibody

The extracts of HeLa (50ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human EIF2S1 (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2b AT5E10 Purified Hu E, P, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

EIF2A / EIF2S1 antibody

The extracts of HeLa (50ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human EIF2S1 (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2b AT5E10 Purified Hu E, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

EIF2A / EIF2S1 pSer51 antibody

Immunohistochemical analysis of Paraffin-Embedded Human breast carcinoma tissue using AP02522PU eIF2A antibody pSer51 Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

EIF2A / EIF2S1 pSer51 antibody

Immunohistochemical analysis of Paraffin-Embedded Human breast carcinoma tissue using AP02522PU eIF2A antibody pSer51 Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µl / €240.00
  Acris Antibodies GmbH

EIF2A / EIF2S1 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using eIF2a antibody. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

EIF2A / EIF2S1 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using eIF2a antibody. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

EIF2A / EIF2S1 pSer51 antibody

Placenta: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

EIF2A / EIF2S1 pSer49 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using eIF2a pSer49) Antibody (#AP08033PU). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

EIF2A / EIF2S1 pSer49 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using eIF2a pSer49) Antibody (#AP08033PU). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µl / €240.00
  Acris Antibodies GmbH

EIF2A / EIF2S1 antibody

Immunohistochemistry (IHC) analyzes of eIF2alpha antibody (Cat.-No.: AP20746PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

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