EIF2AK2 / PKR antibody

Principal name

EIF2AK2 / PKR antibody

Alternative names for EIF2AK2 / PKR antibody

eIF-2A protein kinase 2, PRKR, Interferon-induced double-stranded RNA-activated protein kinase, Eukaryotic translation initiation factor 2-alpha kinase 2, Protein kinase RNA-activated, p68 kinase

SwissProt ID

P19525 (Human), Q03963 (Mouse), Q63184 (Rat), Q9UTE5 (Schpo)

Gene ID

5610 (EIF2AK2), 19106 (Eif2ak2), 54287

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection))

Background of EIF2AK2 / PKR antibody

Interferon-induced, double-stranded RNA-activated protein kinase (PRKR) is a serine-threonine kinase. Activation by dsRNAs leads to autophosphorylation of PRKR and allows the kinase to phosphorylate its natural substrate, the alpha subunit of eukaryotic protein synthesis initiation factor-2 (EIF2-alpha), leading to the inhibition of protein synthesis. Human gamma-interferon (IFNG) mRNA exploits localized activation of PRKR in the cell to regulate its own translation. IFNG mRNA activates PRKR through a pseudoknot in its 5-prime untranslated region. The HCV envelope protein E2 contains a sequence identical with phosphorylation sites of the interferon-inducible protein kinase PRKR and the translation initiation factor EIF2-alpha, a target of PRKR. E2 inhibits the kinase activity of PRKR and blocks its inhibitory effect on protein synthesis and cell growth, which provides one mechanism by which HCV may circumvent the antiviral effect of interferon. PRKR, which is involved in TLR signaling and mediates apoptosis in fibroblasts in response to viral infection and inflammatory cytokines, also activates IKK and NFKB, thereby suppressing apoptosis. Apoptosis induced by live pathogenic gram-positive and gram-negative bacteria requirs both TLR4 and PRKR, possibly representing a major mechanism for pathogenic bacteria that use specific virulence factors to avoid detection and destruction by the innate immune system. Roles for PRKR activation in Huntington disease and Fanconi anemia have also been suggested.

General readings

Nallagatla,S.R. (2008) RNA 14 (6), 1201-1213

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

EIF2AK2 / PKR antibody

Immunoperoxidase of monoclonal antibody to EIF2AK2 on formalin-fixed paraffin-embedded human cerebral cortex. [antibody concentration 3 ug/ml] Mouse IgG2a 1B9 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

EIF2AK2 / PKR antibody

Immunoperoxidase of monoclonal antibody to EIF2AK2 on formalin-fixed paraffin-embedded human adrenal gland. [antibody concentration 1.5 ug/ml] Mouse IgG1 1D11 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

EIF2AK2 / PKR (C-term) antibody

  Rabbit Polyclonal PKR Antibody  
Western blot analysis of PKR in A431 whole cell lysate with PKR antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EIF2AK2 / PKR (N-term) antibody

  Rabbit Polyclonal PKR Antibody  
Western blot analysis of PKR in Caco-2 whole cell lysate with PKR antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EIF2AK2 / PKR antibody

  Rabbit polyclonal PKR (Ab-451) antibody  
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using PKR (Ab-451) Antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

EIF2AK2 / PKR antibody

  Rabbit polyclonal PKR (Thr451) antibody(Phospho-specific)  
Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using PKR (phospho-Thr451) antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

EIF2AK2 / PKR antibody

  Anti-EIF2AK2 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human breast cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using EIF2AK2 antibody at dilution 1/60, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

EIF2AK2 / PKR antibody

  Anti-EIF2AK2 (Phospho-Thr446) Rabbit Polyclonal Antibody  
Predicted band size: 62 kDa . Positive control: K562 cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1: Treated with the peptide Lane2: K562 cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

EIF2AK2 / PKR antibody

  Rabbit Polyclonal PKR Antibody  
Western blot analysis of PKR expression in Starvation treated K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

EIF2AK2 / PKR antibody

  Rabbit Polyclonal PKR (Thr446) Antibody (Phospho-specific)  
Western blot analysis of PKR phosphorylation expression in Starvation treated K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

EIF2AK2 / PKR antibody

  Rabbit anti-Eif2ak2 Polyclonal Antibody  
Western blot analysis of extracts of MCF7 cell line, using Eif2ak2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

EIF2AK2 / PKR pThr446 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue, using PKR pThr446 antibody AP02523PU Rabbit Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

EIF2AK2 / PKR pThr446 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue, using PKR pThr446 antibody AP02523PU Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µl / €240.00
  Acris Antibodies GmbH

EIF2AK2 / PKR pThr451 antibody

Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using PKR antibody (AP02528PU-S; AP02528PU-N). Rabbit Aff - Purified Hu P
0.1 ml / €320.00
  Acris Antibodies GmbH

EIF2AK2 / PKR pThr451 antibody

Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using PKR antibody (AP02528PU-S; AP02528PU-N). Rabbit Aff - Purified Hu P
50 µl / €240.00
  Acris Antibodies GmbH

EIF2AK2 / PKR antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PKR antibody. Rabbit Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

EIF2AK2 / PKR antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PKR antibody. Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

EIF2AK2 / PKR antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using PKR antibody AP02776PU. Rabbit Aff - Purified Hu ICC/IF, P
0.1 ml / €270.00
  Acris Antibodies GmbH

EIF2AK2 / PKR antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using PKR antibody AP02776PU. Rabbit Aff - Purified Hu ICC/IF, P
50 µl / €230.00
  Acris Antibodies GmbH

EIF2AK2 / PKR antibody

Liver: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

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