EIF2AK4 / GCN2 antibody

Principal name

EIF2AK4 / GCN2 antibody

Alternative names for EIF2AK4 / GCN2 antibody

KIAA1338, GCN2-like protein, Eukaryotic translation initiation factor 2-alpha kinase 4

SwissProt ID

Q9CUV9 (Mouse), Q9P2K8 (Human), Q9QZ05 (Mouse)

Gene ID

440275 (EIF2AK4), 27103 (Eif2ak4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of EIF2AK4 / GCN2 antibody

EIF2AK4 (Eukaryotic Translation Initiation Factor 2-Alpha Kinase 4), also called GCN2, is an enzyme that in humans is encoded by the EIF2AK4 gene. EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 to downregulate protein synthesis in response to varied cellular stresses. Hartz (2005) mapped the EIF2AK4 gene to chromosome 15q15.1 based on an alignment of the EIF2AK4 sequence with the genomic sequence. Berlanga et al. (1999) demonstrated that Gcn2 immunopurified from mouse liver extracts could phosphorylate rabbit Eif2 in vitro. Serum starvation increased the level of phosphorylated EIF2-alpha more than 2-fold in human embryonic kidney cells transfected with mouse Eif2ak4. Costa-Mattioli et al. (2005) reported a unique feature of hippocampal slices from Gcn2-null mice: in CA1, a single 100-Hz train induced a strong and sustained long-term potentiation (late LTP or L-LTP), which was dependent on transcription and translation.

13 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

EIF2AK4 / GCN2 (N-term) antibody

  Rabbit Polyclonal Antibody against EIF2AK4 (N-term G11)  
Western blot analysis of GCN2 (arrow) using GCN2 Antibody (N-term G11) (Cat.#TA302175). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GCN2 gene (Lane 2) (Origene Technologies). Rabbit Ig Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EIF2AK4 / GCN2 antibody

  Rabbit Polyclonal Anti-EIF2AK4 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using (EIF2AK4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

EIF2AK4 / GCN2 (120-330) antibody

Brain, cortex: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu P, WB
50 µl / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

EIF2AK4 - human gene knockout kit via CRISPR

EIF2AK4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

EIF2AK4 - human gene knockout kit via CRISPR

EIF2AK4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

EIF2AK4 - human gene knockout kit via CRISPR

EIF2AK4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Eif2ak4 - mouse gene knockout kit via CRISPR

Eif2ak4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Eif2ak4 - mouse gene knockout kit via CRISPR

Eif2ak4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Eif2ak4 - mouse gene knockout kit via CRISPR

Eif2ak4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Eif2ak4 - mouse gene knockout kit via CRISPR

Eif2ak4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, EIF2AK4 (Myc-DDK tagged) - Human eukaryotic translation initiation factor 2 alpha kinase 4 (EIF2AK4), 200 uL, >10^7 TU/mL

Lenti ORF particles, EIF2AK4 (Myc-DDK tagged) - Human eukaryotic translation initiation factor 2 alpha kinase 4 (EIF2AK4), 200 uL, >10^7 TU/mL  
200 µl / €2,280.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Eif2ak4 (GFP-tagged) - Mouse eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Eif2ak4 (GFP-tagged) - Mouse eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,640.00
  OriGene Technologies, Inc.

Lenti ORF particles, Eif2ak4 (Myc-DDK-tagged) - Mouse eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Eif2ak4 (Myc-DDK-tagged) - Mouse eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,380.00
  OriGene Technologies, Inc.

13 Item(s)

per page
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