EIF2AK4 / GCN2 antibody

Principal name

EIF2AK4 / GCN2 antibody

Alternative names for EIF2AK4 / GCN2 antibody

KIAA1338, GCN2-like protein, Eukaryotic translation initiation factor 2-alpha kinase 4

SwissProt ID

Q9CUV9 (Mouse), Q9P2K8 (Human), Q9QZ05 (Mouse)

Gene ID

440275 (EIF2AK4), 27103 (Eif2ak4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of EIF2AK4 / GCN2 antibody

EIF2AK4 (Eukaryotic Translation Initiation Factor 2-Alpha Kinase 4), also called GCN2, is an enzyme that in humans is encoded by the EIF2AK4 gene. EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 to downregulate protein synthesis in response to varied cellular stresses. Hartz (2005) mapped the EIF2AK4 gene to chromosome 15q15.1 based on an alignment of the EIF2AK4 sequence with the genomic sequence. Berlanga et al. (1999) demonstrated that Gcn2 immunopurified from mouse liver extracts could phosphorylate rabbit Eif2 in vitro. Serum starvation increased the level of phosphorylated EIF2-alpha more than 2-fold in human embryonic kidney cells transfected with mouse Eif2ak4. Costa-Mattioli et al. (2005) reported a unique feature of hippocampal slices from Gcn2-null mice: in CA1, a single 100-Hz train induced a strong and sustained long-term potentiation (late LTP or L-LTP), which was dependent on transcription and translation.

General readings

Guo, F. The GCN eIF2 alpha Kinase Regulates Fatty-Acid Homeostasis in the Liver during Deprivation of and Essential Amino Acid. Cell Metabolism, 5: 103-114, 2007.

13 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

EIF2AK4 / GCN2 (N-term) antibody

Western blot analysis of GCN2 (arrow) using GCN2 Antibody (N-term G11) (Cat.#TA302175). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GCN2 gene (Lane 2) (Origene Technologies). Rabbit Ig Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EIF2AK4 / GCN2 (120-330) antibody

Brain, cortex: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu P, WB
50 µl / €470.00
  Acris Antibodies GmbH

EIF2AK4 / GCN2 antibody

EIF2AK4 / GCN2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

EIF2AK4 / GCN2 antibody

EIF2AK4 / GCN2 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

EIF2AK4 / GCN2 antibody

EIF2AK4 / GCN2 Rabbit IgG Aff - Purified Hu WB
0.1 mg / €290.00
  Boster Immunoleader

EIF2AK4 / GCN2 antibody

EIF2AK4 / GCN2 Rabbit IgG Aff - Purified Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

EIF2AK4 / GCN2 antibody

Western Blot and Immunoprecipitation: GCN2 Antibody [NB100-1593] - Detection of Human GCN2 on HeLa whole cell lysate using NB100-1593. GCN2 was also immunoprecipitated using another GCN2 Ab. Rabbit Aff - Purified Hu IP, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

EIF2AK4 / GCN2 antibody

Western Blot: GCN2 Antibody [NBP1-31679] - Western Blot on H1299 (lane A) and Molt-4 (lane B), diluted at 1:1000. Rabbit IgG Hu ICC/IF, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

EIF2AK4 / GCN2

EIF2AK4 / GCN2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

EIF2AK4 / GCN2

EIF2AK4 / GCN2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

EIF2AK4 / GCN2

EIF2AK4 / GCN2 Human 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

EIF2AK4 / GCN2

EIF2AK4 / GCN2 Human 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

EIF2AK4 / GCN2

EIF2AK4 / GCN2 Human
5 µg / €530.00
  Abnova Taiwan Corp.

13 Item(s)

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