EIF2C2 / AGO2 antibody

Principal name

EIF2C2 / AGO2 antibody

Alternative names for EIF2C2 / AGO2 antibody

hAgo-2, Protein argonaute-2, Protein slicer, PAZ Piwi domain protein, Eukaryotic translation initiation factor 2C2, eIF-2C 2, PPD

SwissProt ID

O77503 (Rabit), Q6QME8 (Bovin), Q8CJG0 (Mouse), Q9QZ81 (Rat), Q9UKV8 (Human)

Gene ID

27161 (EIF2C2), 239528 (Eif2c2), 59117

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of EIF2C2 / AGO2 antibody

AGO2 is a highly basic protein that contains a PAZ domain and PIWI domain. It is one of the four members of the mammalian Argonaute protein family (AGO1-4). Among the four members, AGO2 is the only member that possesses the slicer endonuclease activity. Argonaute proteins participate in the various steps of microRNA-mediated gene silencing, such as translational repression and mRNA turnover. The important roles of these small, non-coding RNAs on regulating gene expression in higher eukaryotes have been recently identified. The binding of EIF2C2/AGO2 to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA) forms minimal RNA-induced silencing complex (RISC). When RISC binds to a perfectly complementary mRNA, generally it will result in silencing due to endonucleolytic cleavage of the mRNA specifically by EIF2C2/AGO2. In contrast, the binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. Knockout mice studies revealed the essential function of AGO2 in embryonic development in mice.

19 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

EIF2C2 / AGO2 antibody

  Anti-AGO2 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human thyroid cancer tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using AGO2 antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

EIF2C2 / AGO2 antibody

  Mouse Monoclonal Ago (Argonautes) Antibody  
EIF2C2 / AGO2 Mouse IgG1 Monoclol Purified Hu, Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

AGO2 - human gene knockout kit via CRISPR

AGO2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

AGO2 - human gene knockout kit via CRISPR

AGO2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

AGO2 - human gene knockout kit via CRISPR

AGO2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

AGO2 - human gene knockout kit via CRISPR

AGO2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ago2 - mouse gene knockout kit via CRISPR

Ago2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ago2 - mouse gene knockout kit via CRISPR

Ago2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ago2 - mouse gene knockout kit via CRISPR

Ago2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ago2 - mouse gene knockout kit via CRISPR

Ago2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

EIF2C2 / AGO2 (transcript variant 2)

  Purified recombinant protein of Homo sapiens eukaryotic translation initiation factor 2C, 2 (EIF2C2), transcript variant 2.  
EIF2C2 / AGO2 Human > 80 %
Preparation: or Add: Recombint proteins was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, AGO2 (mGFP-tagged) - Human eukaryotic translation initiation factor 2C, 2 (EIF2C2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, AGO2 (mGFP-tagged) - Human eukaryotic translation initiation factor 2C, 2 (EIF2C2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,820.00
  OriGene Technologies, Inc.

Lenti ORF particles, AGO2 (mGFP-tagged) - Human eukaryotic translation initiation factor 2C, 2 (EIF2C2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, AGO2 (mGFP-tagged) - Human eukaryotic translation initiation factor 2C, 2 (EIF2C2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,770.00
  OriGene Technologies, Inc.

Lenti ORF particles, AGO2 (Myc-DDK tagged) - Human eukaryotic translation initiation factor 2C, 2 (EIF2C2), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, AGO2 (Myc-DDK tagged) - Human eukaryotic translation initiation factor 2C, 2 (EIF2C2), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €1,640.00
  OriGene Technologies, Inc.

Lenti ORF particles, AGO2 (Myc-DDK tagged) - Human eukaryotic translation initiation factor 2C, 2 (EIF2C2), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, AGO2 (Myc-DDK tagged) - Human eukaryotic translation initiation factor 2C, 2 (EIF2C2), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €1,590.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ago2 (GFP-tagged) - Mouse eukaryotic translation initiation factor 2C, 2 (Eif2c2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ago2 (GFP-tagged) - Mouse eukaryotic translation initiation factor 2C, 2 (Eif2c2), 200 uL, >10^7 TU/mL  
200 µl / €1,590.00
  OriGene Technologies, Inc.

Lenti ORF particles, Ago2 (Myc-DDK-tagged) - Mouse eukaryotic translation initiation factor 2C, 2 (Eif2c2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ago2 (Myc-DDK-tagged) - Mouse eukaryotic translation initiation factor 2C, 2 (Eif2c2), 200 uL, >10^7 TU/mL  
200 µl / €1,430.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Eif2c2 (GFP-tagged ORF) - Rat eukaryotic translation initiation factor 2C, 2 (Eif2c2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Eif2c2 (GFP-tagged ORF) - Rat eukaryotic translation initiation factor 2C, 2 (Eif2c2), 200 uL, >10^7 TU/mL  
200 µl / €1,600.00
  OriGene Technologies, Inc.

Lenti ORF particles, Eif2c2 (Myc-DDK-tagged ORF) - Rat eukaryotic translation initiation factor 2C, 2 (Eif2c2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Eif2c2 (Myc-DDK-tagged ORF) - Rat eukaryotic translation initiation factor 2C, 2 (Eif2c2), 200 uL, >10^7 TU/mL  
200 µl / €1,437.00
  OriGene Technologies, Inc.

19 Item(s)

per page
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