EIF4G1 / EIF4F antibody

Principal name

EIF4G1 / EIF4F antibody

Alternative names for EIF4G1 / EIF4F antibody

EIF4G, EIF4GI, eIF-4-gamma 1, eIF-4G 1, eIF-4G1, Eukaryotic translation initiation factor 4 gamma 1, p220

SwissProt ID

P41110 (Rabit), Q04637 (Human), Q6NZJ6 (Mouse)

Gene ID

1981 (EIF4G1)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Rb (Rabbit), Por (Porcine), Bov (Bovine), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of EIF4G1 / EIF4F antibody

The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq].eIF4G1 (eukaryotic translation Initiation Factor 4 Gamma 1) is a component of the protein complex eIF-4 which is involved in the recognition of the mRNA cap ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of mRNA to the ribosome. eIF4G plays a critical role in protein expression and is at the center of a complex regulatory network. Together with the cap-binding protein eIF4E, it recruits the small ribosomal subunit to the 5'-end of mRNA and promotes the assembly of a functional translation initiation complex which scans along the mRNA to the translation start codon. Human eIF4G contains three consecutive HEAT domains, as well as long unstructured regions involved in multiple protein-protein interactions. The interactions of eIF4G1 with other factors are largely unknown.

General readings

General / background references:Bolster DR et al. AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J Biol Chem 277:23977-80 (2002). PubMed PMID: 11997383
DeGracia DJ et al. Molecular pathways of protein synthesis inhibition during brain reperfusion: implications for neuronal survival or death. J Cereb Blood Flow Metab 22:127-41 (2002). PubMed PMID: 11823711
Raught B et al. Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. EMBO J 19:434-44 (2000). PubMed PMID: 10654941
Pyronnet S et al. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J 18:270-9 (1999). PubMed PMID: 9878069

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

EIF4G1 / EIF4F antibody

Immunofluorescence of monoclonal antibody to EIF4G1 on HeLa cell. [antibody concentration 10 ug/ml] Mouse IgG2b 2A9 Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

EIF4G1 / EIF4F antibody

WB Suggested Anti-EIF4G1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: HepG2 cell lysateEIF4G1 is supported by BioGPS gene expression data to be expressed in HepG2 Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

EIF4G1 / EIF4F antibody

Immunohistochemistry (IHC) analysis of eIF4G antibody (Cat.-No.: AP06520PU-N) in paraffin-embedded human colon carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P
0.1 mg / €350.00
  Acris Antibodies GmbH

EIF4G1 / EIF4F pSer1232 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using eIF4G (phospho-Ser1232) antibody AP08034PU. Rabbit Aff - Purified Hu P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

EIF4G1 / EIF4F pSer1232 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using eIF4G (phospho-Ser1232) antibody AP08034PU. Rabbit Aff - Purified Hu P, WB
50 µl / €240.00
  Acris Antibodies GmbH

EIF4G1 / EIF4F antibody

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using eIF4G Antibody. Rabbit Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

EIF4G1 / EIF4F antibody

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using eIF4G Antibody. Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

EIF4G1 / EIF4F antibody

EIF4G1 / EIF4F Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

EIF4G1 / EIF4F antibody

Immunofluorescence of purified MaxPab antibody to EIF4G1 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

EIF4G1 / EIF4F antibody

EIF4G1 monoclonal antibody (M01), clone 3A10. Western Blot analysis of EIF4G1 expression in NIH/3T3(Cat # L018V1 ). Mouse IgG2a 3A10 Purified Hu, Ms E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

EIF4G1 / EIF4F antibody

Imunohistochemical analysis of paraffin-embedded human lung carcinoma tissue, using EIF4G1 polyclonal antibody ( Cat # PAB7699 ). Rabbit Hu ICC/IF, P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

EIF4G1 / EIF4F pSer1108 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using eIF4G (Phospho-Ser1108) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
50 µg / €205.00
  Assay Biotech

EIF4G1 / EIF4F pSer1108 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using eIF4G (Phospho-Ser1108) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €310.00
  Assay Biotech

EIF4G1 / EIF4F antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using eIF4G (Ab-1108) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €205.00
  Assay Biotech

EIF4G1 / EIF4F antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using eIF4G (Ab-1108) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €310.00
  Assay Biotech

EIF4G1 / EIF4F (Center) antibody

Human HepG2; WB Suggested Anti-EIF4G1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: HepG2 cell lysate. EIF4G1 is supported by BioGPS gene expression data to be expressed in HepG2.; EIF4G1 antibody - middle region (ARP40562_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Hu, Ms, Rb, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

EIF4G1 / EIF4F antibody

Western blot analysis of EIF4G1 expression in HEK293T (A); HeLa (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Por, Rb, Rt ICC/IF, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

EIF4G1 / EIF4F antibody

Western blot analysis of EIF4G1 expression in HEK293T (A); HeLa (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Por, Rb, Rt ICC/IF, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

EIF4G1 / EIF4F antibody

Western blot analysis of EIF4G1 expression in HEK293T (A); HeLa (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Por, Rb, Rt ICC/IF, P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

EIF4G1 / EIF4F antibody

Western Blot and Immunoprecipitation: eIF4G1 Antibody [NB100-268] - Detection of eIF4G on HeLa whole cell lysate using NB100-268. Rabbit Aff - Purified Hu, Rt IP, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

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