Elafin / PI3 antibody

Principal name

Elafin / PI3 antibody

Alternative names for Elafin / PI3 antibody

Elastase-specific inhibitor, ESI, Peptidase inhibitor 3, PI-3, SKALP, WAP3, WFDC14, Skin-derived antileukoproteinase, Protease inhibitor WAP3, WAP four-disulfide core domain protein 14

SwissProt ID

P19957 (Human), Q29125 (Pig)

Gene ID

5266 (PI3)

Available reactivities

Hu (Human), Bov (Bovine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P)

Background of Elafin / PI3 antibody

Elafin is an epithelial proteinase inhibitor also known under various other names such as Skin-derived Anti leukoproteinase (SKALP) and Elastase-Specific Inhibitor (ESI). Elafin belongs to the Trappin gene family and was given the systematic name Trappin-2. The Trappin family is defined by a N-terminal transglutaminase substrate domain and a C-terminal four disulphide core. Trappins have been suggested to play a role in the regulation of inflammation and in protection against tissue damage in stratified epithelia. Elafin is an inhibitor of leukocyte elastase and proteinase-3 and is a substrate for transglutaminases. The protein is constitutively expressed in various epithelia including hair follicles, oesophagus, vagina and oral cavity. Elafin is not present in normal human skin but is strongly induced during inflammation as in psoriasis and wound healing. Antibodies to elafin can be used to evaluate the effects of treatment of psoriasis since its expression is significantly correlated with clinical scores. Antibodies to elafin have also been succesfully used to study differentiation in squamous cell carcinoma of the head-and-neck region, oesophagus and skin. It is also shown that elafin possesses antimicrobial activity against gram-positive and gram-negative bacteria.

General readings

Saheki T, et al (1992) Biochem Biophys Res Commun. 185(1):240-5.Molhuizen HO, et al (1993) J Biol Chem. 268(16):12028-32.Wiedow O, et al (1990) J Biol Chem. 265(25):14791-5.

18 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Elafin / PI3 antibody

  Rabbit Polyclonal Skalp Antibody  
ELISA: SKALP Antibody Rabbit IgG Purified Hu E
50 µg / €325.00
  OriGene Technologies, Inc.

Elafin / PI3 (C-term) antibody

Elafin / PI3 Mouse IgG2b TRAB2F Purified Hu E, P, WB
0.1 mg / €500.00
  Acris Antibodies GmbH

Elafin / PI3 antibody

Elafin / PI3 Mouse IgG1 TRAB2O Purified Hu E, P, WB
0.1 mg / €500.00
  Acris Antibodies GmbH

Elafin / PI3 antibody

Elafin / PI3 Goat Serum Hu E, P, WB
1 ml / €460.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PI3 - human gene knockout kit via CRISPR

PI3 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PI3 - human gene knockout kit via CRISPR

PI3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PI3 - human gene knockout kit via CRISPR

PI3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PI3 - human gene knockout kit via CRISPR

PI3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Elafin / PI3

  Recombinant protein of human peptidase inhibitor 3, skin-derived (PI3)  
Elafin / PI3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Elafin / PI3

  Purified recombinant protein of Human peptidase inhibitor 3, skin-derived (PI3)  
Elafin / PI3 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €139.00
  OriGene Technologies, Inc.

Elafin / PI3 (23-117, His-tag)

Elafin / PI3 Human Purified > 80 % by SDS - PAGE E. coli
0.25 mg / €730.00
  Acris Antibodies GmbH

Elafin / PI3 (23-117, His-tag)

Elafin / PI3 Human Purified > 80 % by SDS - PAGE E. coli
50 µg / €300.00
  Acris Antibodies GmbH

Elafin / PI3 (23-117, His-tag)

Elafin / PI3 Human Purified > 85 % by SDS - PAGE.
0.25 mg / €1,230.00
  Acris Antibodies GmbH

Elafin / PI3 (23-117, His-tag)

Elafin / PI3 Human Purified > 85 % by SDS - PAGE.
50 µg / €370.00
  Acris Antibodies GmbH

ELISA Kits

Catalog No.    

Human Elafin/PI3 ELISA Kit

Human Elafin/PI3 ELISA Kit  
1 kit / €389.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

PI3 overexpression lysate

PI3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PI3 (mGFP-tagged) - Human peptidase inhibitor 3, skin-derived (PI3), 200 uL, >10^7 TU/mL

Lenti ORF particles, PI3 (mGFP-tagged) - Human peptidase inhibitor 3, skin-derived (PI3), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, PI3 (Myc-DDK tagged) - Human peptidase inhibitor 3, skin-derived (PI3) , 200 uL, >10^7 TU/mL

Lenti ORF particles, PI3 (Myc-DDK tagged) - Human peptidase inhibitor 3, skin-derived (PI3) , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

18 Item(s)

per page
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