ELAVL2 / HUB antibody

Principal name

ELAVL2 / HUB antibody

Alternative names for ELAVL2 / HUB antibody

ELAV-like protein 2, Hu-antigen B, Hel-N1, ELAV-like neuronal protein 1, Nervous system-specific RNA-binding protein Hel-N1

SwissProt ID

Q12926 (Human), Q60899 (Mouse), Q8CH84 (Rat)

Gene ID

1993 (ELAVL2), 15569 (Elavl2), 286973

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of ELAVL2 / HUB antibody

The Elav-like genes encode for a family of RNA-binding proteins. Elav, a Drosophila protein and the first described member, is expressed immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. Several mammalian Elav-like proteins, designated HuC, HuD and Hel-N1, are also expressed in postmitotic neurons. An additional mammalian homolog, HuR, which is also designated HuA, is ubiquitously expressed and is also overexpressed in a wide variety of tumors. Characteristically, these homologs all contain three RNA recognition motifs (RRM), and they specifically bind to AU-rich elements (ARE) in the 3'-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation.

General readings

Joeson L., et al. (2007) Mol. Cell. Proteomics 6:798-811.

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