ELMO2 antibody

Principal name

ELMO2 antibody

Alternative names for ELMO2 antibody

ELMO 2, ELMO-2, CED12A, CED-12A, KIAA1834, Engulfment and cell motility protein 2, CED-12 homolog A

SwissProt ID

A4FUD6 (Bovin), Q8BHL5 (Mouse), Q96JJ3 (Human)

Gene ID

63916, 9844 (ELMO1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine)

Available hosts

Rabbit, Goat, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection))

Background of ELMO2 antibody

Elmo (engulfment and cell motility) proteins share similarity to C. elegans CED-12. The C. elegans genes ced-2, ced-5, ced-10, and ced-12 and their mammalian homologs CRKII, DOCK1, RAC1 and ELMO mediate cytoskeletal rearrangements during phagocytosis of apoptotic cells and cell motility. Elmo1 associates with DOCK 180 and may influence phagocytosis and effect cell shape changes. Src family kinase mediated tyrosine phosphorylation of ELMO1 influences signaling through Elmo1/Crk/DOCK 180 pathways. Elmo2 interacts directly with Rho G in a GTP-dependent manner and forms a ternary complex with DOCK 180 to induce activation of Rac 1. The RhoG-Elmo2-DOCK 180 pathway is required for activation of Rac 1 and cell spreading mediated by integrin, as well as for neurite outgrowth induced by nerve growth factor. Elmo3 acts in assocation with DOCK180 and Crk II and may be required in complex with DOCK180 to activate Rac/Rho small GTPases.

General readings

Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen JM, Haney LB, Nishiwaki K, Walk SF, Nemergut ME, Macara IG, Francis R, Schedl T, Qin Y, Van Aelst L, Hengartner MO, Ravichandran KS.
CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.
Cell. 2001 Oct 5;107(1):27-41.
PMID: 11595183

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ELMO2 (C-term) antibody

TA302760 staining (2µg/ml) of Human Brain lysate (RIPA buffer, 30µg total protein per lane).  Primary incubated for 12 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ELMO2 (707-720) antibody

Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Bear, Bov, Bt, Can, Chk, Elephant, Eq, Hst, Hu, Mky, Ms, Op, Prim, Rb, Rt, Xen P, WB
50 µg / €470.00
  Acris Antibodies GmbH

ELMO2 (Center) antibody

Formalin fixed and paraffin embedded human skeletal muscle reacted with ELMO2 Antibody Cat.-No AP51418PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ELMO2 antibody

Western Blot analysis of ELMO2 expression in transfected 293T cell line (H00063916-T01) by ELMO2 MaxPab polyclonal antibody.

Lane 1: ELMO2 transfected lysate(79.2 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

ELMO2 antibody

ELMO2 Mouse IgG2b 3G7 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

ELMO2 antibody

ELMO2 Mouse IgG2a 2E5 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

ELMO2 antibody

ELMO2 polyclonal antibody ( Cat # PAB6106 ) staining ( 2 µg/ml ) of human brain lysate ( RIPA buffer, 30 µg total protein per lane ) . Primary incubated for 12 hour. Detected by western blot using chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

ELMO2 antibody

Immunohistochemistry-Paraffin: ELMO2 Antibody [NB100-879] - (3.8ug/ml) staining of paraffin embedded Human Prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat IgG Aff - Purified Hu E, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

ELMO2 antibody

Immunohistochemistry-Paraffin: ELMO2 Antibody [NBP1-84554] - Immunohistochemical staining of human smooth muscle shows cytoplasmic positivity in smooth muscle cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ELMO2 (transcript variant 1)

ELMO2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ELMO2 (transcript variant 2)

ELMO2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ELMO2

ELMO2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

ELMO2

ELMO2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

ELMO2

ELMO2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ELMO2

ELMO2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

ELMO2 Lysate(Denatured)

ELMO2 Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

ELMO2 overexpression lysate

ELMO2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

17 Item(s)

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