ELP1 / IKBKAP antibody

Principal name

ELP1 / IKBKAP antibody

Alternative names for ELP1 / IKBKAP antibody

Elongator complex protein 1, IKAP, p150, IkappaB kinase complex-associated protein, IKK complex-associated protein

SwissProt ID

O95163 (Human), Q2TAQ1 (Xenla), Q7TT37 (Mouse), Q8VHU4 (Rat), Q8WND5 (Rabit), Q9CT81 (Mouse)

Gene ID

8518 (IKBKAP), 230233 (Ikbkap)

Available reactivities

Hu (Human), Bt (Bat), Bov (Bovine), Can (Canine), Chk (Chicken), Eq (Equine), Fi (Fish), Hst (Hamster), Mky (Monkey), Ms (Mouse), Op (Opossum), Por (Porcine), Prim (Primate), Rb (Rabbit), Rt (Rat), Tr (Turkey), Bear

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of ELP1 / IKBKAP antibody

IGBP1 (also known as Alpha4) , binds to PP2A C in the absense of A and a B subunit in a catalytically inactive state to prevent C proteosomal degradation. If alpha4 levels are low, PP2A levels can decrease, leading to increased tau protein phosphorylation and aggregation. Protein phosphatase 2A is a heterotrimeric protein serine/threonine phosphatase consisting of a 36-kD catalytic C subunit (alpha and beta isoforms), a 65-kD structural A subunit (alpha and beta isoforms), and a variable regulatory B subunit. When the PP2A catalytic C subunit associates with the A and B subunits several species of holoenzymes are produced with distinct functions and characteristics. Ubiquitously expressed, PP2A is involved in a broad range of cellular processes, including membrane receptor desensitization, signal transduction, intermediary metabolism, transcriptional regulation and control of DNA replication, and mitosis. The PP2A phosphatase family accounts for the majority of Ser/Thr phosphatase activity in the brain and specifically regulates tau phosphorylation, both directly as tau phosphatase and indirectly by regulating the activities of several tau kinases which include CaM Kinase II, PKA, MAP kinase kinase (MEK 1/2), extracellular regulated kinase (ERK 1/2), GSK-3 beta;, and P70S6 kinase, thus regulating tau microtubule binding in the brain.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ELP1 / IKBKAP antibody

  Rabbit Polyclonal IKAP Antibody  
Western blot analysis of IKAP in A-20 cell lysate with IKAP antibody at in (A) 0.5, and (B) 1 ug/mL. Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ELP1 / IKBKAP antibody

  Rabbit Polyclonal IKBKAP Antibody  
Western Blot: IKBKAP Antibody [TA336679] - Analysis of IKBKAP in Interleukin-1-stimulated 293 cells using this antibody at 1:500 dilution. Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ELP1 / IKBKAP antibody

  Rabbit Polyclonal IKBKAP Antibody  
Western Blot: IKBKAP Antibody [TA336680] - Analysis of IKBKAP in Interleukin-1-stimulated 293 cells using TA336680 at 1:500 dilution Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ELP1 / IKBKAP (148-161) antibody

Lung, nerve: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Bov, Can, Elephant, Eq, Hu, Platypus, Por, Rb E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

ELP1 / IKBKAP (C-term) antibody

Figure 2. Formalin-Fixed Paraffin-Embedded (FFPE) on Testis. Rabbit Purified Hu, Ms ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

ELP1 / IKBKAP (C-term) antibody

Western blot of  IKAP (1:500) in HEK293 cells stimulated with interleukin-1 Rabbit Purified Hu WB
0.1 ml / €330.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

Ikbkap - mouse gene knockout kit via CRISPR

Ikbkap - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ikbkap - mouse gene knockout kit via CRISPR

Ikbkap - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ikbkap - mouse gene knockout kit via CRISPR

Ikbkap - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ikbkap - mouse gene knockout kit via CRISPR

Ikbkap - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ELP1 / IKBKAP

  Recombinant protein of human inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (IKBKAP)  
ELP1 / IKBKAP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, IKBKAP (mGFP-tagged) - Human inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (IKBKAP), 200 uL, >10^7 TU/mL

Lenti ORF particles, IKBKAP (mGFP-tagged) - Human inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (IKBKAP), 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, IKBKAP (Myc-DDK tagged) - Human inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (IKBKAP) , 200 uL, >10^7 TU/mL

Lenti ORF particles, IKBKAP (Myc-DDK tagged) - Human inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (IKBKAP) , 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ikbkap (GFP-tagged) - Mouse inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein (Ikbkap), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ikbkap (GFP-tagged) - Mouse inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein (Ikbkap), 200 uL, >10^7 TU/mL  
200 µl / €2,220.00
  OriGene Technologies, Inc.

Lenti ORF particles, Ikbkap (Myc-DDK-tagged) - Mouse inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein (Ikbkap), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ikbkap (Myc-DDK-tagged) - Mouse inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein (Ikbkap), 200 uL, >10^7 TU/mL  
200 µl / €2,000.00
  OriGene Technologies, Inc.

15 Item(s)

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