Endonuclease G antibody

Principal name

Endonuclease G antibody

Alternative names for Endonuclease G antibody

ENDOG

SwissProt ID

O08600 (Mouse), P38447 (Bovin), Q14249 (Human)

Gene ID

2021 (ENDOG)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of Endonuclease G antibody

The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribonuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (EndoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD. EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis.
The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in C. elegans.
EndoG also cleaves DNA in vitro.

General readings

General / background references:Parrish J et al. Mitochondrial endonuclease G is important for apoptosis in C. elegans. Nature 412:90-4 (2001). PubMed PMID: 11452313
Li LY et al. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412:95-9 (2001). PubMed PMID: 11452314
Tiranti V et al. Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis. Genomics 25:559-64 (1995). PubMed PMID: 7789991

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Endonuclease G antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-ENDOG mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504189) Mouse IgG1 OTI5F1 Purified Hu F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Endonuclease G antibody

Western blot analysis of EndoG in mouse (M) 3T3 and human (H) HepG2 cell lysates with EndoG antibody at 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Endonuclease G (51-140) antibody

Western blot analysis of EndoG expression in HepG2 cell lysate with EndoG antibody at (A) 2.5 and (B) 5 ug/mL. Mouse IgG 7G1C10 Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Endonuclease G (51-140) antibody

Western blot analysis of EndoG expression in HepG2 cell lysate with EndoG antibody at (A) 5 and (B) 10 ug/mL. Mouse IgG 7G1G10 Aff - Purified Hu, Ms E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Endonuclease G (51-140) antibody

Western blot analysis of EndoG expression in HepG2 cell lysate with EndoG antibody at (A) 5 and (B) 10 ug/mL. Mouse IgG 7F2D7 Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Endonuclease G (51-140) antibody

Western blot analysis of EndoG expression in HepG2 cell lysate with EndoG antibody at (A) 5 and (B) 10 ug/mL. Mouse IgG 7F2G10 Aff - Purified Hu, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Endonuclease G antibody

WB Suggested Anti-ENDOG Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human Intestine Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Endonuclease G (C-term) antibody

Western blot analysis of ENDOG Antibody (C-term) (AP17329PU-N) in 293, K562, Jurkat, NCI-H460 cell line lysates and mouse kidney tissues lysates(35 µg/lane). ENDOG (arrow) was detected using the purified Pab. Rabbit Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Endonuclease G antibody

AP26343PU-N: Western blot analysis of EndoG expression in rat kidney issue lysate. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €370.00
  Acris Antibodies GmbH

Endonuclease G Control Peptide

Endonuclease G
50 µg / €160.00
  Acris Antibodies GmbH

Endonuclease G antibody

EndoG - SP1412P staining of human pancreas with anti-EndoG at 15 µg/ml. Formalin fixed paraffin processed tissue. Rabbit Purified Hu, Ms, Rt P, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

Endonuclease G antibody

EndoG - SP1412P staining of human pancreas with anti-EndoG at 15 µg/ml. Formalin fixed paraffin processed tissue. Rabbit IgG Purified Hu, Ms, Rt P, WB
50 µg / €270.00
  Acris Antibodies GmbH

Endonuclease G antibody

Western Blot analysis of ENDOG expression in transfected 293T cell line (H00002021-T01) by ENDOG MaxPab polyclonal antibody.

Lane 1: ENDOG transfected lysate(32.78 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

Endonuclease G antibody

Endonuclease G Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Endonuclease G antibody

Western blot analysis of ENDOG expression in HepG2 cell lysate with ENDOG monoclonal antibody, clone 7G1C10 ( Cat # MAB2758 ) at ( A ) 2.5 and ( B ) 5 µg/ml. Mouse IgG 7G1C10 Hu, Ms, Rt WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Endonuclease G antibody

Western blot analysis of ENDOG expression in HepG2 cell lysate with ENDOG monoclonal antibody, clone 7G1G10 ( Cat # MAB2759 ) at ( A ) 5 and ( B ) 10 µg/ml. Mouse IgG 7G1G10 Hu, Rt WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Endonuclease G antibody

Western blot analysis of ENDOG expression in HepG2 cell lysate with ENDOG monoclonal antibody, clone 7F2D7 ( Cat # MAB2760 ) at ( A ) 5 and ( B ) 10 µg/ml. Mouse IgG 7F2D7 Hu, Ms, Rt WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Endonuclease G antibody

Western blot analysis of ENDOG expression in HepG2 cell lysate with ENDOG monoclonal antibody, clone 7F2G10 ( Cat # MAB2761 ) at ( A ) 5 and ( B ) 10 µg/ml. Mouse IgG 7F2G10 Hu, Rt WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Endonuclease G antibody

Western blot analysis of Endog expression in rat kidney issue lysate. Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Endonuclease G antibody

Immunohistochemistry of ENDOG in human pancreas with ENDOG polyclonal antibody ( Cat # PAB12884 ) at 15 µg/ml. Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

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